Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export [PDF]
, 2014 This work is supported by grants from the Wellcome Trust (grants 087751/A/08/Z) and MRC (G1001726/1).We have examined the requirements for virus transcription and replication and thus the roles of input and progeny genomes in the generation of interferon
Randall, Richard E +3 more
core +1 more source
Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex
Nature Communications, 2023 Nuclear export of influenza A virus (IAV) mRNAs occurs through the nuclear pore complex (NPC). Using the Auxin-Induced Degron (AID) system to rapidly degrade proteins, we show that among the nucleoporins localized at the nucleoplasmic side of the NPC ...
Prasanna Bhat +18 more
doaj +1 more source
Ratcheted transport and sequential assembly of the yeast telomerase RNP
Cell Reports, 2023 Summary: The telomerase ribonucleoprotein particle (RNP) replenishes telomeric DNA and minimally requires an RNA component and a catalytic protein subunit.
Hannah Neumann +3 more
doaj +1 more source
Comparative genomics of proteins involved in RNA nucleocytoplasmic export
BMC Evolutionary Biology, 2011 Background The establishment of the nuclear membrane resulted in the physical separation of transcription and translation, and presented early eukaryotes with a formidable challenge: how to shuttle RNA from the nucleus to the locus of protein synthesis ...
Goldenberg Samuel +4 more
doaj +1 more source
The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function
Nature Communications, 2023 PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis, linking external stimuli to transcriptional co-activation of genes involved in adaptive and age-related pathways.
Simeon R. Mihaylov +15 more
doaj +1 more source
Open Biology, 2020 The human immunodeficiency virus type 1 (HIV-1) proteome is expressed from alternatively spliced and unspliced genomic RNAs. However, HIV-1 RNAs that are not fully spliced are perceived by the host machinery as defective and are retained in the nucleus ...
Catherine Toni-Sue Truman +3 more
doaj +1 more source
Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]
, 2007 A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David +2 more
core +1 more source
Chemical intervention of influenza virus mRNA nuclear export.
PLoS Pathogens, 2020 Influenza A viruses are human pathogens with limited therapeutic options. Therefore, it is crucial to devise strategies for the identification of new classes of antiviral medications. The influenza A virus genome is constituted of 8 RNA segments.
Matthew Esparza +18 more
doaj +1 more source
Nuclear export of human hepatitis B virus core protein and pregenomic RNA depends on the cellular NXF1-p15 machinery. [PDF]
PLoS ONE, 2014 Hepatitis B virus (HBV) core protein (HBc) can shuttle between nucleus and cytoplasm. Cytoplasm-predominant HBc is clinically associated with severe liver inflammation.
Ching-Chun Yang +4 more
doaj +1 more source
RNA-specific ribonucleotidyl transferases [PDF]
, 2007 RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W. +3 more
core +1 more source