Results 1 to 10 of about 547,775 (258)

Role of m⁶A in Embryonic Stem Cell Differentiation and in Gametogenesis

Epigenomes, 2020
The rising field of RNA modifications is stimulating massive research nowadays. m6A, the most abundant mRNA modification is highly conserved during evolution.
Lior Lasman, Jacob H Hanna, Noa Novershtern   +2 more
doaj   +1 more source

RNA Modification in Carcinogenesis and Development of Gastric Cancer

Zhongliu Fangzhi Yanjiu, 2023
The occurrence of gastric cancer is closely related to environmental, genetic, and epigenetic factors. Currently, RNA modification is a research frontier and hotspot in the field of epigenetics.
XU Jiawen, WANG Qiang, WANG Shouyu
doaj   +1 more source

It’s the Little Things (in Viral RNA)

mBio, 2020
Chemical modifications of viral RNA are an integral part of the viral life cycle and are present in most classes of viruses. To date, more than 170 RNA modifications have been discovered in all types of cellular RNA.
Jiří František Potužník, Hana Cahová   +1 more
doaj   +1 more source

The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene

Epigenetics, 2020
The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins.
Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C. Dedon, J. Andres Melendez, Laura Van Winkle, Qing-Yu Zhang, Xinxin Ding, Thomas J. Begley   +12 more
doaj   +1 more source

RNA modification-mediated translational control in immune cells

RNA Biology, 2023
RNA modifications play a vital role in multiple pathways of mRNA metabolism, and translational regulation is essential for immune cells to promptly respond to stimuli and adapt to the microenvironment.
Yujuan Zhang, Weiguo Hu, Hua-Bing Li
doaj   +1 more source

The Identification of Two RNA Modification Patterns and Tumor Microenvironment Infiltration Characterization of Lung Adenocarcinoma

Frontiers in Genetics, 2022
Background: RNA modification plays an important role in many diseases. A comprehensive study of tumor microenvironment (TME) characteristics mediated by RNA modification regulators will improve the understanding of TME immune regulation.Methods: We ...
Wan He, Gengpeng Lin, Chaohu Pan, Chaohu Pan, Chaohu Pan, Wenwen Li, Jing Shen, Yangli Liu, Hui Li, Dongfang Wu, Xuejia Lin, Xuejia Lin   +11 more
doaj   +1 more source

microRNA-mediated differential expression of TRMU, GTPBP3 and MTO1 in cell models of mitochondrial-DNA diseases

Scientific Reports, 2017
Mitochondrial diseases due to mutations in the mitochondrial (mt) DNA are heterogeneous in clinical manifestations but usually include OXPHOS dysfunction. Mechanisms by which OXPHOS dysfunction contributes to the disease phenotype invoke, apart from cell
Salvador Meseguer, Olga Boix, Carmen Navarro-González, Magda Villarroya, Rachid Boutoual, Sonia Emperador, Elena García-Arumí, Julio Montoya, M.-Eugenia Armengod   +8 more
doaj   +1 more source

Comprehensive identification of diverse ribosomal RNA modifications by targeted nanopore direct RNA sequencing and JACUSA2

RNA Biology, 2023
Ribosomal RNAs are decorated by numerous post-transcriptional modifications whose exact roles in ribosome biogenesis, function, and human pathophysiology remain largely unknown.
Isabel S. Naarmann-de Vries, Christiane Zorbas, Amina Lemsara, Michael Piechotta, Felix G. M. Ernst, Ludivine Wacheul, Denis L. J. Lafontaine, Christoph Dieterich   +7 more
doaj   +1 more source

RNA modification of an RNA modifier prevents self-RNA sensing.

PLoS Biology, 2021
A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during
Daltry L Snider, Stacy M Horner
doaj   +1 more source

Nanoparticle-Induced m⁶A RNA Modification: Detection Methods, Mechanisms and Applications

Nanomaterials, 2022
With the increasing application of nanoparticles (NPs) in medical and consumer applications, it is necessary to ensure their safety. As m6A (N6-methyladenosine) RNA modification is one of the most prevalent RNA modifications involved in many diseases and
Yi Wang, Fengkai Ruan, Zhenghong Zuo, Chengyong He   +3 more
doaj   +1 more source