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RNA Modification in Metabolism [PDF]
MedCommEpigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and the most prevalent modification in RNA is N6‐methyladenosine (m6A).
Yadi Liu +4 more
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Cancer Management and Research, 2022 Zhiyuan Yang,1,2,* Siyu Zhang,1,2,* Tian Xia,1,2,* Yue Fan,1,2 Ying Shan,1,2 Kaiwen Zhang,1,2 Jiayan Xiong,1,2 Miao Gu,1,2 Bo You1,2 1Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical ...
Yang Z +8 more
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RNA modification mapping with JACUSA2
Genome Biology, 2022 Several high-throughput antibody-free methods for RNA modification detection from sequencing data have been developed. We present JACUSA2 as a versatile software solution and comprehensive analysis framework for RNA modification detection assays that are
Michael Piechotta +4 more
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GlycoRNA, a novel RNA modification [PDF]
Discover OncologyRNA plays a variety of critical roles in cellular environments, including serving as a structural molecule, messenger molecule, translational carrier, and effector molecule.
Binbin Hu +4 more
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Comprehensive mapping of RNA modification dynamics and crosstalk via deep learning and nanopore direct RNA-sequencing [PDF]
Nature CommunicationsDespite the extensive studies of individual RNA modifications, the lack of methods to detect multiple modification types simultaneously has left the global epitranscriptomic landscape and its underlying crosstalk largely unexplored. Here, we present ORCA
Han Dong +6 more
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RNA modification of an RNA modifier prevents self-RNA sensing.
PLoS Biology, 2021 A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during
Daltry L Snider, Stacy M Horner
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YModPred: an interpretable prediction method for multi-type RNA modification sites in S. cerevisiae based on deep learning [PDF]
BMC BiologyBackground RNA post-transcriptional modifications involve the addition of chemical groups to RNA molecules or alterations to their local structure. These modifications can change RNA base pairing, affect thermal stability, and influence RNA folding ...
Chunyan Ao +4 more
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RNA Modification and Its Implication in Plant Pathogenic Fungi [PDF]
The Plant Pathology Journal, 2021 Interaction of a pathogen with its host plant requires both flexibility and rapid shift in gene expression programs in response to environmental cues associated with host cells. Recently, a growing volume of data on the diversity and ubiquity of internal
Junhyun Jeon, Song Hee Lee
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RNA Biology, 2022 The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine by the Dus family of NADPH-dependent reductases and is typically found within the eponym D-loop of tRNAs.
Olivier Finet +3 more
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RNA modifications and cancer [PDF]
RNA Biology, 2020 RNA plays essential roles in not only translating nucleic acids into proteins, but also in gene regulation, environmental interactions and many human diseases. Nature uses over 150 chemical modifications to decorate RNA and diversify its functions. With the fast-growing RNA research in the burgeoning field of 'epitranscriptome', a term describes post ...
Phensinee Haruehanroengra +4 more
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