Results 41 to 50 of about 547,775 (258)

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

RNA modifications in cancer

MedComm
AbstractRNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such as N6‐methyladenosine (m6A) and 5‐methylcytosine (m5C), are implicated in various cellular processes. These modifications are regulated by proteins that write, erase, and read RNA and modulate RNA stability ...
Han Wu, Shi Chen, Xiang Li, Yuyang Li, He Shi, Yiwen Qing, Bohe Shi, Yifei Tang, Zhuoyi Yan, Yang Hao, Dongxu Wang, Weiwei Liu   +11 more
openaire   +3 more sources

Crosstalk Between Four Types of RNA Modification Writers Characterizes the Tumor Immune Microenvironment Infiltration Patterns in Skin Cutaneous Melanoma

Frontiers in Cell and Developmental Biology, 2022
The “writers” of four types of adenosine (A)-related RNA modifications (N6-methyladenosine, N1-methyladenosine, alternative polyadenylation, as well as A-to-inosine RNA editing) are closely related to the tumorigenesis and progression of many cancer ...
Shichao Zhang, Yu Xiong, Chaochao Zheng, Jinhua Long, Houming Zhou, Zhu Zeng, Yan Ouyang, Fuzhou Tang   +7 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Research Progress on Epigenetic Regulation of Fungal Secondary Metabolism

Guangdong nongye kexue
Fungi are capable of synthesizing a wide array of secondary metabolites with diverse structures and biological activities, which have significant applications in agriculture, medicine, food, and industry.
Siyi TAN, Guanxian CHEN, Lei HE, Qingqing ZHI   +3 more
doaj   +1 more source

RNA modifications in mammals: from basic research to biotechnological application [PDF]

ExRNA
RNA, a crucial molecule in protein synthesis and gene expression regulation, plays an essential role in organisms. RNA modifications, acting as epigenetic marks, subtly adjust the structure, stability, and function of RNA, thereby regulating gene ...
Yihang Li, Yongle Liu, Hongyuan Guo, Zheng Fu   +3 more
doaj   +1 more source

Regulatory role and mechanism of m6A RNA modification in human metabolic diseases

Molecular Therapy: Oncolytics, 2021
Metabolic diseases caused by disorders in amino acids, glucose, lipid metabolism, and other metabolic risk factors show high incidences in young people, and current treatments are ineffective.
Yuliang Zhang, Wenjie Chen, Xiwang Zheng, Yujia Guo, Jimin Cao, Yu Zhang, Shuxin Wen, Wei Gao, Yongyan Wu   +8 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

RNA 5-Methylcytosine Modification in Myocardial Fibrosis

Reviews in Cardiovascular Medicine
Myocardial fibrosis represents a common pathological hallmark of various cardiovascular diseases progressing to heart failure, with the immunoinflammatory response playing a pivotal role in the pathogenesis of myocardial fibrosis.
Bohan Li, Yan Hao, Wendan Tian, Wei Liu
doaj   +1 more source

Molecular Characterization of m6A Modifications in Non-Clear Cell Renal Cell Carcinoma and Potential Relationship with Pathological Types

International Journal of General Medicine, 2022
Xuebao Xiang, Yi Guo, Zhongyuan Chen, Zengnan Mo Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical ...
Xiang X, Guo Y, Chen Z, Mo Z
doaj