Results 41 to 50 of about 855,003 (301)

RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]

, 2013
Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Ahmed, Allison, Beckerman, Bunz, Burnett, Carthew, Castanotto, Chen, Chendrimada, Dunn, Ford, Ford, Haigis, Haringsma, Hirao, Jiang, Jiang, Jiang, Jollès, Khan, Kim, Knight, Liu, Liu, Lynch, Parker, Peritz, Rao, Rivas, Réfrégiers, Shah, Siomi, Song, Vickers, Wang, Wang, Wang, Ye, Yoshizawa   +38 more
core   +2 more sources

SnapShot: Messenger RNA Modifications

Cell, 2018
mRNA modifications are defining a novel layer of complexity that is becoming widely appreciated as the epitranscriptome. This SnapShot summarizes the major breakthroughs in the burgeoning field of mRNA modifications to provide an overview of the molecular players involved and insights gained into the functional consequences of the growing number of ...
Veronica, Davalos, Sandra, Blanco, Manel, Esteller   +2 more
openaire   +2 more sources

Characterization of N6-methyladenosine long non-coding RNAs in sporadic congenital cataract and age-related cataract [PDF]

International Journal of Ophthalmology
AIM: To characterize the N6-methyladenosine (m6A) modification patterns in long non-coding RNAs (lncRNAs) in sporadic congenital cataract (CC) and age-related cataract (ARC).
Hong-Fei Ye, Xiang Zhang, Zhen-Nan Zhao, Ce Zheng, Ping Fei, Yu Xu, Jiao Lyu, Ji-Li Chen, Xun-Xiang Guo, Huang Zhu, Pei-Quan Zhao   +10 more
doaj   +1 more source

Trisomy 21 alters DNA methylation in parent-of-origin-dependent and independent manners [PDF]

, 2016
The supernumerary chromosome 21 in Down syndrome differentially affects the methylation statuses at CpG dinucleotide sites and creates genome-wide transcriptional dysregulation of parental alleles, ultimately causing diverse pathologies.
Alves da Silva, Antônio Francisco, Biselli-Périco, Joice Matos, Chuva de Sousa Lopes, Susana Marina, Fernandes, Maria Gomes, Francisco Junior, Ronaldo da Silva, Lopes Rios, Álvaro Fabricio, Machado, Douglas Terra, Machado, Filipe Brum, Medina-Acosta, Enrique, Mozer Rodrigues, Pedro Thyago, Pavarino, Érika Cristina, Santos-Rebouças, Cíntia Barros, Zampieri, Bruna Lancia   +12 more
core   +3 more sources

Chemical Modifications of Ribosomal RNA

, 2022
AbstractCellular RNAs in all three kingdoms of life are modified with diverse chemical modifications. These chemical modifications expand the topological repertoire of RNAs, and fine-tune their functions. Ribosomal RNA in yeast contains more than 100 chemically modified residues in the functionally crucial and evolutionary conserved regions.
Sunny, Sharma, Karl-Dieter, Entian
openaire   +2 more sources

Gene Expression Profile and Prognostic Value of m6A RNA Methylation Regulators in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2021
Xian Chang,1,* Yang-Fan Lv,2,* Jing He,3,* Ya Cao,2 Chang-Qing Li,1 Qiao-Nan Guo2 1Department of Orthopedics, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, 400037, People’s Republic of China; 2Department ...
Chang X, Lv YF, He J, Cao Y, Li CQ, Guo QN   +5 more
doaj  

Crosstalk Between Four Types of RNA Modification Writers Characterizes the Tumor Immune Microenvironment Infiltration Patterns in Skin Cutaneous Melanoma

Frontiers in Cell and Developmental Biology, 2022
The “writers” of four types of adenosine (A)-related RNA modifications (N6-methyladenosine, N1-methyladenosine, alternative polyadenylation, as well as A-to-inosine RNA editing) are closely related to the tumorigenesis and progression of many cancer ...
Shichao Zhang, Yu Xiong, Chaochao Zheng, Jinhua Long, Houming Zhou, Zhu Zeng, Yan Ouyang, Fuzhou Tang   +7 more
doaj   +1 more source

Statistical modeling of RNA structure profiling experiments enables parsimonious reconstruction of structure landscapes. [PDF]

, 2018
RNA plays key regulatory roles in diverse cellular processes, where its functionality often derives from folding into and converting between structures.
Aviran, Sharon, Li, Hua
core   +2 more sources

Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication

mBio, 2021
The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an ongoing global public crisis. Although viral RNA modification has been reported based on the transcriptome architecture, the types and ...
Xueyan Zhang, Haojie Hao, Li Ma, Yecheng Zhang, Xiao Hu, Zhen Chen, Di Liu, Jianhui Yuan, Zhangli Hu, Wuxiang Guan   +9 more
doaj   +1 more source

RAM function is dependent on Kapβ2-mediated nuclear entry [PDF]

, 2014
Eukaryotic gene expression is dependent on the modification of the first transcribed nucleotide of pre-mRNA by the addition of the 7-methylguanosine cap.
Aregger, Buratowski, Cansizoglu, Chook, Chu, Cowling, Cowling, Dormann, Fridell, Glover-Cutter, Gonatopoulos-Pournatzis, Lee, Li, Perales, Rebane, Shafer, Shatkin, Shuman, Suzuki, Süel, Thomas Gonatopoulos-Pournatzis, Topisirovic, Van Dusen, Victoria H. Cowling, Xu   +24 more
core   +4 more sources