The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections
Frontiers in Genetics, 2023 Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during viral infections. By modulating the modification landscape of viral and host RNAs, viruses enhance their propagation and elude host surveillance mechanisms.
Alexandre Nunes, Ana Raquel Soares
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Bioinformatics approaches for deciphering the epitranscriptome: Recent progress and emerging topics
Computational and Structural Biotechnology Journal, 2020 Post-transcriptional RNA modification occurs on all types of RNA and plays a vital role in regulating every aspect of RNA function. Thanks to the development of high-throughput sequencing technologies, transcriptome-wide profiling of RNA modifications ...
Jionglong Su, Lian Liu, Yufei Huang
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Host norepinephrine biases codon-dependent virulence translation in EHEC [PDF]
mSystemsBacterial pathogens sense host-derived signals to control virulence, yet how these cues shape translation remains unclear. McShane et al. show that the host hormone norepinephrine rewires the tRNA epitranscriptome of enterohemorrhagic Escherichia coli ...
Zeynep Baharoglu
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Advanced ScienceGut microbiota can influence host gene expression and physiology through metabolites. Besides, the presence or absence of gut microbiome can reprogram host transcriptome and epitranscriptome as represented by N6‐methyladenosine (m6A), the most abundant ...
Xiaoyun Wang
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Quantifying the mRNA epitranscriptome reveals epitranscriptome signatures and roles in cancer
Cellular and Molecular Life SciencesPost-transcriptional modifications on mRNA are crucial for mRNA fate and function. The current lack of a comprehensive method for high-coverage and sensitive quantitative analysis of mRNA modifications significantly limits the discovery of new mRNA ...
Ying Feng +11 more
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Rewriting the Fate of Cancer: Epigenetic and Epitranscriptomic Regulators in the Metastatic Cascade [PDF]
BiomoleculesMetastasis is the leading cause of cancer-related mortality, representing a highly coordinated, multistep process in which malignant cells gain the ability to invade, survive in the circulation, and establish secondary tumors at distant sites.
Toshifumi Hara, Murugan Subramanian
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Epitranscriptome and FMRP Regulated mRNA Translation
Epigenomes, 2017 An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian
Pritha Majumder, Biswanath Chatterjee
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Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation [PDF]
Cell GenomicsSummary: As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms.
Haozhe Wang +10 more
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Advanced deep learning strategies in nanopore RNA sequencing [PDF]
RNA BiologyThe epitranscriptome comprises chemical modifications found on RNA molecules that play essential roles in co- and post-transcriptional gene regulation.
Crystal Ling +3 more
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Transcriptomic and RNA Modification Landscape of Severe Fever with Thrombocytopenia Syndrome Virus Revealed by Nanopore Direct RNA Sequencing [PDF]
MicroorganismsSevere Fever with Thrombocytopenia Syndrome (SFTS) is caused by the SFTS virus (SFTSV) and is associated with a high mortality rate. Although previous studies have reported RNA modifications such as m6A on SFTSV RNA, an integrated analysis of native ...
Haowen Yuan +9 more
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