Results 1 to 10 of about 3,251 (178)

Lifestyle modifications: coordinating the tRNA epitranscriptome with codon bias to adapt translation during stress responses

Genome Biology, 2018
Cells adapt to stress by altering gene expression at multiple levels. Here, we propose a new mechanism regulating stress-dependent gene expression at the level of translation, with coordinated interplay between the tRNA epitranscriptome and biased codon ...
Cheryl Chan, Phuong Pham, Peter C. Dedon, Thomas J. Begley   +3 more
doaj   +1 more source

Anti‐cancer effect of entacaponeon esophageal cancer cells via apoptosis induction and cell cycle modulation

Cancer Reports, 2023
Background Esophageal cancer (EC) is the sixth leading cause of cancer‐related death, despite many advances in treatment, the survival of patients still remains poor.
Fahimeh Ramedani, Seyyed Mehdi Jafari, Marie Saghaeian Jazi, Zeinab Mohammadi, Jahanbakhsh Asadi   +4 more
doaj   +1 more source

N6-Methyladenosine: A Novel RNA Imprint in Human Cancer

Frontiers in Oncology, 2019
N6-Methyladenosine (m6A), a pervasive posttranscriptional modification which is reversible, has been among hotspot issues in the past several years.
Sihui Yu, Xi Li, Shiyun Liu, Rui Yang, Xiangnan Liu, Sufang Wu   +5 more
doaj   +1 more source

Epitranscriptomic N4-Acetylcytidine Profiling in CD4+ T Cells of Systemic Lupus Erythematosus

Frontiers in Cell and Developmental Biology, 2020
The emerging epitranscriptome plays an essential role in autoimmune disease. As a novel mRNA modification, N4-acetylcytidine (ac4C) could promote mRNA stability and translational efficiency. However, whether epigenetic mechanisms of RNA ac4C modification
Gangqiang Guo, Gangqiang Guo, Xinyu Shi, Huijing Wang, Lele Ye, Lele Ye, Xinya Tong, Kejing Yan, Ning Ding, Chaosheng Chen, Huidi Zhang, Xiangyang Xue   +11 more
doaj   +1 more source

Charting new territory: The Plasmodium falciparum tRNA modification landscape

Biomedical Journal
Ribonucleoside modifications comprising the epitranscriptome are present in all organisms and all forms of RNA, including mRNA, rRNA and tRNA, the three major RNA components of the translational machinery.
Benjamin Sian Teck Lee, Ameya Sinha, Peter Dedon, Peter Preiser   +3 more
doaj   +1 more source

Interpretable deep cross networks unveiled common signatures of dysregulated epitranscriptomes across 12 cancer types

Molecular Therapy: Nucleic Acids
Cancer is a complex and multifaceted group of diseases characterized by uncontrolled cell growth that leads to the formation of malignant tumors. Recent studies suggest that N6-methyladenosine (m6A) RNA methylation plays pivotal roles in cancer pathology
Rong Xia, Xiangyu Yin, Jiaming Huang, Kunqi Chen, Jiongming Ma, Zhen Wei, Jionglong Su, Neil Blake, Daniel J. Rigden, Jia Meng, Bowen Song   +10 more
doaj   +1 more source

Analysis of Transcriptome and Epitranscriptome in Plants Using PacBio Iso-Seq and Nanopore-Based Direct RNA Sequencing

Frontiers in Genetics, 2019
Nanopore sequencing from Oxford Nanopore Technologies (ONT) and Pacific BioSciences (PacBio) single-molecule real-time (SMRT) long-read isoform sequencing (Iso-Seq) are revolutionizing the way transcriptomes are analyzed.
Liangzhen Zhao, Hangxiao Zhang, Markus V. Kohnen, Kasavajhala V. S. K. Prasad, Lianfeng Gu, Anireddy S. N. Reddy   +5 more
doaj   +1 more source

RNA Modification Related Diseases and Sensing Methods

Applied Sciences, 2023
Epitranscriptomics is the study of RNA base modifications, including functionally relevant transcriptomic changes. Epitranscriptomics has been actively studied in recent years and has been reported to play important roles in development, homeostasis, the
Mayuka Ohkawa, Masamitsu Konno
doaj   +1 more source

The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies

Ibrain
Neurodegenerative disorders encompass a group of age‐related conditions characterized by the gradual decline in both the structure and functionality of the central nervous system (CNS).
Muhammad Abu Talha Safdar Hashmi, Hooriya Fatima, Sadia Ahmad, Amna Rehman, Fiza Safdar   +4 more
doaj   +1 more source

The Dihydrouridine landscape from tRNA to mRNA: a perspective on synthesis, structural impact and function

RNA Biology, 2022
The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine by the Dus family of NADPH-dependent reductases and is typically found within the eponym D-loop of tRNAs.
Olivier Finet, Carlo Yague-Sanz, Florian Marchand, Damien Hermand   +3 more
doaj   +1 more source