The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections [PDF]
Frontiers in Genetics, 2023 Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during viral infections. By modulating the modification landscape of viral and host RNAs, viruses enhance their propagation and elude host surveillance mechanisms.
Alexandre Nunes, Ana R Soares
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Bioinformatics approaches for deciphering the epitranscriptome: Recent progress and emerging topics
Computational and Structural Biotechnology Journal, 2020 Post-transcriptional RNA modification occurs on all types of RNA and plays a vital role in regulating every aspect of RNA function. Thanks to the development of high-throughput sequencing technologies, transcriptome-wide profiling of RNA modifications ...
Lian Liu, Bowen Song, Song-Yao Zhang
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Antibiotic‐Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism [PDF]
Advanced ScienceGut microbiota can influence host gene expression and physiology through metabolites. Besides, the presence or absence of gut microbiome can reprogram host transcriptome and epitranscriptome as represented by N6‐methyladenosine (m6A), the most abundant ...
Xiaoyun Wang, Tong-Meng Yan
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Host norepinephrine biases codon-dependent virulence translation in EHEC [PDF]
mSystemsBacterial pathogens sense host-derived signals to control virulence, yet how these cues shape translation remains unclear. McShane et al. show that the host hormone norepinephrine rewires the tRNA epitranscriptome of enterohemorrhagic Escherichia coli ...
Zeynep Baharoglu
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Rewriting the RNA code: an m6a-centric framework to classify tumors and guide combination therapies [PDF]
Frontiers in ImmunologyBackgroundThe epitranscriptome, particularly N6-methyladenosine (m6A), represents a dynamic layer of post-transcriptional regulation fundamentally implicated in cancer.
Yi Sun +6 more
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Rewriting the Fate of Cancer: Epigenetic and Epitranscriptomic Regulators in the Metastatic Cascade [PDF]
BiomoleculesMetastasis is the leading cause of cancer-related mortality, representing a highly coordinated, multistep process in which malignant cells gain the ability to invade, survive in the circulation, and establish secondary tumors at distant sites.
Toshifumi Hara, Murugan Subramanian
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Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation [PDF]
Cell GenomicsSummary: As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms.
Haozhe Wang +10 more
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Transcriptomic and RNA Modification Landscape of Severe Fever with Thrombocytopenia Syndrome Virus Revealed by Nanopore Direct RNA Sequencing [PDF]
MicroorganismsSevere Fever with Thrombocytopenia Syndrome (SFTS) is caused by the SFTS virus (SFTSV) and is associated with a high mortality rate. Although previous studies have reported RNA modifications such as m6A on SFTSV RNA, an integrated analysis of native ...
Haowen Yuan +9 more
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Epitranscriptomic profile of Lactobacillus agilis and its adaptation to growth on inulin
BMC Research Notes, 2021 Objective Ribonucleic acids (RNA) are involved in many cellular functions. In general, RNA is made up by only four different ribonucleotides. The modifications of RNA (epitranscriptome) can greatly enhance the structural diversity of RNA, which in turn ...
Hongzhou Wang +6 more
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Recent advances in the plant epitranscriptome
Genome Biology, 2023 Chemical modifications of RNAs, known as the epitranscriptome, are emerging as widespread regulatory mechanisms underlying gene regulation. The field of epitranscriptomics advances recently due to improved transcriptome-wide sequencing strategies for ...
Lisha Shen +4 more
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