Bioinformatics approaches for deciphering the epitranscriptome: Recent progress and emerging topics
Computational and Structural Biotechnology Journal, 2020 Post-transcriptional RNA modification occurs on all types of RNA and plays a vital role in regulating every aspect of RNA function. Thanks to the development of high-throughput sequencing technologies, transcriptome-wide profiling of RNA modifications ...
Lian Liu, Bowen Song, Xiangyu Wu
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Rewriting the Fate of Cancer: Epigenetic and Epitranscriptomic Regulators in the Metastatic Cascade [PDF]
BiomoleculesMetastasis is the leading cause of cancer-related mortality, representing a highly coordinated, multistep process in which malignant cells gain the ability to invade, survive in the circulation, and establish secondary tumors at distant sites.
Toshifumi Hara, Murugan Subramanian
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Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation [PDF]
Cell GenomicsSummary: As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms.
Haozhe Wang +10 more
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Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions. [PDF]
Ecol EvolDormancy is presented as a conserved, reversible survival program in which epitranscriptomic RNA modifications are proposed to provide a rapid, energy‐efficient layer that establishes, maintains, and terminates the state by modulating mRNA stability, translation, and localization.
Pashay Ahi E.
europepmc +2 more sources
Integrated genetic analysis reveals synaptic m6A enrichment in high-risk autism genes [PDF]
Frontiers in Molecular NeuroscienceAutism Spectrum Disorder (ASD), a complex neurodevelopmental condition, is characterised by reduced social and emotional expression and repetitive patterns of behaviour. The clinical observations of defects in brain development and disrupted connectivity
Shreya Doijad +3 more
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Epitranscriptomic profile of Lactobacillus agilis and its adaptation to growth on inulin
BMC Research Notes, 2021 Objective Ribonucleic acids (RNA) are involved in many cellular functions. In general, RNA is made up by only four different ribonucleotides. The modifications of RNA (epitranscriptome) can greatly enhance the structural diversity of RNA, which in turn ...
Hongzhou Wang +6 more
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The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections
Frontiers in Genetics, 2023 Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during viral infections. By modulating the modification landscape of viral and host RNAs, viruses enhance their propagation and elude host surveillance mechanisms.
Diana Roberta Ribeiro +3 more
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Recent advances in the plant epitranscriptome
Genome Biology, 2023 Chemical modifications of RNAs, known as the epitranscriptome, are emerging as widespread regulatory mechanisms underlying gene regulation. The field of epitranscriptomics advances recently due to improved transcriptome-wide sequencing strategies for ...
Lisha Shen +4 more
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Frontiers in Genetics, 2023 Introduction: Dihydrouridine (D) is a conserved modification of tRNA among all three life domains. D modification enhances the flexibility of a single nucleotide base in the spatial structure and is disease- and evolution-associated.
Jinjin Ren +6 more
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Refined RIP-seq protocol for epitranscriptome analysis with low input materials. [PDF]
PLoS Biology, 2018 N6-Methyladenosine (m6A) accounts for approximately 0.2% to 0.6% of all adenosine in mammalian mRNA, representing the most abundant internal mRNA modifications.
Yong Zeng +11 more
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