Results 41 to 50 of about 3,547 (209)
Shaping the Bacterial Epitranscriptome—5′‐Terminal and Internal RNA Modifications
, 2021 All domains of life utilize a diverse set of modified ribonucleotides that can impact the sequence, structure, function, stability, and the fate of RNAs, as well as their interactions with other molecules. Today, more than 160 different RNA modifications
Nadiia Pozhydaieva +5 more
core +1 more source
Biomolecules, 2023 The significance of internal mRNA modifications for the modulation of transcript stability, for regulation of nuclear export and translation efficiency, and their role in suppressing innate immunity is well documented.
Milena N. Leseva +3 more
doaj +1 more source
The Epitranscriptome in Translation Regulation [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output.
Eyal, Peer +3 more
openaire +2 more sources
Determinants of the m6A Epitranscriptome [PDF]
, 2022 N6–methyladenosine (m6A) is the most abundant mRNA modification and is crucial for gene expression regulation in numerous biological processes. In mammals, m6A methylation is specifically deposited on a subset of mRNAs and is strongly enriched within ...
He, P. Cody
core +1 more source
Molecular Therapy: Nucleic AcidsCancer is a complex and multifaceted group of diseases characterized by uncontrolled cell growth that leads to the formation of malignant tumors. Recent studies suggest that N6-methyladenosine (m6A) RNA methylation plays pivotal roles in cancer pathology
Rong Xia +10 more
doaj +1 more source
Nanopore direct RNA sequencing and the epitranscriptome: Advances in mapping native RNA landscapes
iMeta, EarlyView.Nanopore direct RNA sequencing advances transcriptomics by capturing full‐length transcripts and multiple RNA modifications; this review details its principles, workflows, tools, applications, challenges, and future research potential. Abstract Nanopore direct RNA sequencing (DRS) has transformed transcriptomics by enabling single‐molecule, long‐read ...
Tianyuan Zhang +27 more
wiley +1 more source
PEA: an integrated R toolkit for plant epitranscriptome analysis
, 2018 Motivation The epitranscriptome, also known as chemical modifications of RNA (CMRs), is a newly discovered layer of gene regulation, the biological importance of which emerged through analysis of only a small fraction of CMRs detected ...
Yunjia Tang +4 more
core +1 more source
Epitranscriptomic investigation of myopia-associated RNA editing in the retina
Frontiers in Neuroscience, 2023 Myopia is one of the most common causes of vision loss globally and is significantly affected by epigenetics. Adenosine-to-inosine (A-to-I RNA) editing is an epigenetic process involved in neurological disorders, yet its role in myopia remains ...
Xu-Bin Pan +24 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Machine learning enabled genetic and functional interpretation of the epitranscriptome [PDF]
Increasing evidence has suggested that RNA modifications regulate many important biological processes. To date, more than 170 types of post-transcriptional RNA modifications have been discovered.
Song, Bowen
core +1 more source