Results 41 to 50 of about 3,251 (178)

The epitranscriptome of Vero cells infected with SARS-CoV-2 assessed by direct RNA sequencing reveals m6A pattern changes and DRACH motif biases in viral and cellular RNAs

Frontiers in Cellular and Infection Microbiology, 2022
The epitranscriptomics of the SARS-CoV-2 infected cell reveals its response to viral replication. Among various types of RNA nucleotide modifications, the m6A is the most common and is involved in several crucial processes of RNA intracellular location ...
João H. C. Campos, Gustavo V. Alves, Juliana T. Maricato, Carla T. Braconi, Fernando M. Antoneli, Luiz Mario R. Janini, Marcelo R. S. Briones   +6 more
doaj   +1 more source

m6Acomet: large-scale functional prediction of individual m6A RNA methylation sites from an RNA co-methylation network

BMC Bioinformatics, 2019
Background Over one hundred different types of post-transcriptional RNA modifications have been identified in human. Researchers discovered that RNA modifications can regulate various biological processes, and RNA methylation, especially N6 ...
Xiangyu Wu, Zhen Wei, Kunqi Chen, Qing Zhang, Jionglong Su, Hui Liu, Lin Zhang, Jia Meng   +7 more
doaj   +1 more source

Cracking the epitranscriptome [PDF]

RNA, 2016
Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made ...
openaire   +2 more sources

Alanine tRNAs Translate Environment Into Behavior in Caenorhabditis elegans

Frontiers in Cell and Developmental Biology, 2020
Caenorhabditis elegans nematodes produce and maintain imprints of attractive chemosensory cues to which they are exposed early in life. Early odor-exposure increases adult chemo-attraction to the same cues.
Diana Andrea Fernandes De Abreu, Thalia Salinas-Giegé, Laurence Drouard, Jean-Jacques Remy   +3 more
doaj   +1 more source

The mammalian mitochondrial epitranscriptome

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019
Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been emerging as an important regulatory feature of mitochondrial gene expression.
Rebelo-Guiomar, Pedro, Powell, Christopher A, Van Haute, Lindsey, Minczuk, Michal   +3 more
openaire   +3 more sources

Dawn of Epitranscriptomic Medicine [PDF]

Circulation: Genomic and Precision Medicine, 2018
Medicine is at the crossroads of expanding disciplines. Prompt adaptation of medicine to each rapidly advancing research field, bridging bench to bedside, is a key step toward health improvement. Cardiovascular disease still ranks first among the mortality causes in the Western world, indicating a poor adaptation rate of cardiovascular medicine, albeit
Gatsiou A, Stellos K
openaire   +3 more sources

The Epitranscriptome in Translation Regulation [PDF]

Cold Spring Harbor Perspectives in Biology, 2018
The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output.
Eyal, Peer, Sharon, Moshitch-Moshkovitz, Gideon, Rechavi, Dan, Dominissini   +3 more
openaire   +2 more sources

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Introduction to ‘The Epitranscriptome’

RSC Chemical Biology
Ralph Kleiner (Princeton University, USA), Claudia Höbartner (University of Würzburg, Germany) and Guifang Jia (Peking University, China) introduce the themed collection on ‘The Epitranscriptome’.
Kleiner, Ralph E., Höbartner, Claudia, Jia, Guifang   +2 more
openaire   +3 more sources