Results 61 to 70 of about 3,251 (178)

Charting the unknown epitranscriptome

Nature Reviews Molecular Cell Biology, 2017
RNA modifications can alter RNA structure-function relationships and various cellular processes. However, the genomic distribution and biological roles of most RNA modifications remain uncharacterized. Here, we propose using phage display antibody technology and direct sequencing through nanopores to facilitate systematic interrogation of the ...
Novoa Pardo, EM, Mason, CE, Mattick, JS
openaire   +3 more sources

Enviromics and Abiotic Enviromics: Enhancing Stress Biology and Plant Resilience Breeding

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Environmental stressors are captured through high‐throughput envirotyping and integrated into an enviromic framework with genomic, transcriptomic, phenomic, and environmental data. AI/ML models enable prediction and guide marker‐assisted selection, genomic selection, genome editing, and gene pyramiding toward improved abiotic stress tolerance, yield ...
Guangchao Sun, Jose Luis Araus, James C. Schnable, Jie Xu, Henry T. Nguyen, Yunbi Xu, Yanli Lu   +6 more
wiley   +1 more source

Downregulation of m6A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness

Molecular Oncology, 2022
N6‐methyladenosine (m6A) and its regulatory proteins have been associated with tumorigenesis in several cancer types. However, knowledge on the mechanistic network related to m6A in bladder cancer (BlCa) is rather limited, requiring further investigation
Catarina Guimarães‐Teixeira, João Lobo, Vera Miranda‐Gonçalves, Daniela Barros‐Silva, Cláudia Martins‐Lima, Sara Monteiro‐Reis, José Pedro Sequeira, Isa Carneiro, Margareta P. Correia, Rui Henrique, Carmen Jerónimo   +10 more
doaj   +1 more source

Epitranscriptomic regulations in the heart

Physiological Research
RNA modifications affect key stages of the RNA life cycle, including splicing, export, decay, and translation. Epitranscriptomic regulations therefore significantly influence cellular physiology and pathophysiology. Here, we selected some of the most abundant modifications and reviewed their roles in the heart and in cardiovascular diseases: N6 ...
Benák, D. (Daniel), Kolář, F. (František), Hlaváčková, M. (Markéta)   +2 more
openaire   +3 more sources

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, Volume 2, Issue 3, September 2026.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Significant epitranscriptomes in heterogeneous cancer [PDF]

Cancer Science, 2019
AbstractPrecision medicine places significant emphasis on techniques for the identification of DNA mutations and gene expression by deep sequencing of gene panels to obtain medical data. However, other diverse information that is not easily readable using bioinformatics, including RNA modifications, has emerged as a novel diagnostic and innovative ...
Masamitsu Konno, Masateru Taniguchi, Hideshi Ishii   +2 more
openaire   +2 more sources

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

TRMT61A‐Mediated m1A Modification Suppresses FDX1 Translation to Drive Cuproptosis Evasion and Radioresistance in Hepatocellular Carcinoma

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This study identifies tRNA methyltransferase 61 A (TRMT61A)‐mediated N1‐methyladenosine (m1A) modification as a driver of radioresistance in hepatocellular carcinoma (HCC) by suppressing cuproptosis. TRMT61A methylates FDX1 mRNA, enabling YTHDF3 recognition and eRF1 recruitment to inhibit FDX1 translation.
Yunyun Xiao, Yue Li, Zelei Li, Rui Wang, Dongni Shi, Yanling Wen, Yibing Pan, Chen Lin, Junguo Bu, Libing Song, Hui Dai   +10 more
wiley   +1 more source

The art of Epitranscriptomics

International Physical Medicine & Rehabilitation Journal, 2022
https://orcid.org/0000-0002-3292 ...
openaire   +1 more source

Epitranscriptomic Regulation of Bone Metabolism: Emerging Roles of N6‐Methyladenosine (m6A) Modification in Skeletal Homeostasis

Oral Science International, Volume 23, Issue 3, September 2026.
ABSTRACT N6‐methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic RNA and a central mechanism of epitranscriptomic gene regulation. Although m6A was first characterized in messenger RNA (mRNA), it is also deposited on ribosomal RNA (rRNA), circular RNA, and other RNA species, where it regulates RNA stability, decay ...
Shoichiro Kokabu, Quan Yuan
wiley   +1 more source