Results 71 to 80 of about 4,508 (221)

Stem cell function and stress response are controlled by protein synthesis. [PDF]

, 2016
Whether protein synthesis and cellular stress response pathways interact to control stem cell function is currently unknown. Here we show that mouse skin stem cells synthesize less protein than their immediate progenitors in vivo, even when forced to ...
A Sobala, Abdulrahim Sajini, AL Means, B Schwanhäusser, CS Trempus, D Ruggero, DB Longley, DE Weinberg, DM Owens, DR Morris, E Fuchs, E Fuchs, F Tuorto, FJ Martinez, H Tang, HC Lin, Hinal Tanna, I Malanchi, J Gebetsberger, J Xing, Jelena Aleksic, JL Hintze, KA Spriggs, KK Youssef, KM Braun, L Abbasi-Moheb, L Madisen, M Egeblad, M Frye, M Frye, M Schaefer, M Schaefer, M Schober, M Sibilia, MA Khan, Martyna Popis, Michaela Frye, MV Gerashchenko, MV Plikus, N Atsumi, N Barker, Nikoletta Gkatza, NT Ingolia, NT Ingolia, NT Ingolia, NT Ingolia, P Ivanov, Patrick Lombard, PD Lu, PV Baranov, RA Signer, Roberto Bandiera, Rosana Cortés-Garrido, RS Joshi, RY Kao, S Blanco, S Blanco, S Hussain, S Hussain, S Hussain, S Hussain, S Müller-Röver, S Schleich, Sabine Dietmann, Sandra Blanco, SE Calvo, Shobbir Hussain, T Schneider-Poetsch, V Jaks, V Khoddami, X Zhang, Y Hirai   +71 more
core   +2 more sources

Recent Acquisition of Functional m6A RNA Demethylase Domain in Orchid Ty3/Gypsy Elements [PDF]

, 2022
[EN] Long terminal repeats (LTR) retrotransposons are transposable elements (TEs) representing major components of most plant genomes. The fixation of additional conserved protein domains in their genomes is considered a rare event in the course of their
Alvarado-Marchena, Luis, APARICIO HERRERO, FREDERIC, Martínez-Pérez, Mireya, Maumus, Florian, Pallás Benet, Vicente   +4 more
core   +2 more sources

Aging through an epitranscriptomic lens

Nature Aging, 2021
The mechanistic causes of aging, the time-related decline in function and good health that leads to increased mortality, remain poorly understood. Here we propose that age-dependent alteration of the epitranscriptome, encompassing more than 150 chemically distinct post-transcriptional modifications or editing events, warrants exploration as an ...
Mary McMahon, Craig Forester, Rochelle Buffenstein   +2 more
openaire   +2 more sources

Single‐Cell and Spatial Omics: Methods and Applications

MedComm, Volume 7, Issue 4, April 2026.
Systematically summarized the breakthrough sequencing technologies and computational methods for single‐cell and spatial omics across multiple omics layers, including genome, epigenome, transcriptome, proteome, and metabolome. State‐of‐the‐art methods for multi‐omics integration, cross‐modal integration, and cross‐scale integration were reviewed, with ...
Xiaoping Cen, Xiaolan Huang, Enjin Deng, Xue Gong, Na Tan, Jifeng Ye, Yin Wang, Roland Eils, Qun Luo, Yixue Li, Fangfang Qu   +10 more
wiley   +1 more source

RNA editing generates cellular subsets with diverse sequence within populations [PDF]

, 2016
RNA editing is a mutational mechanism that specifically alters the nucleotide content in transcribed RNA. However, editing rates vary widely, and could result from equivalent editing amongst individual cells, or represent an average of variable editing ...
Harjanto, D., Oates, Chris J., Papamarkou, Theodore, Papavasiliou, Anastasia, Papavasiliou, F. N., Rayon-Estrada, V.   +5 more
core   +1 more source

The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies

Ibrain
Neurodegenerative disorders encompass a group of age‐related conditions characterized by the gradual decline in both the structure and functionality of the central nervous system (CNS).
Muhammad Abu Talha Safdar Hashmi, Hooriya Fatima, Sadia Ahmad, Amna Rehman, Fiza Safdar   +4 more
doaj   +1 more source

Epitranscriptome and FMRP Regulated mRNA Translation

Epigenomes, 2017
An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian
Pritha Majumder, Biswanath Chatterjee, C.-K. James Shen   +2 more
doaj   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

RNA N⁶-Methyladenosine Affects Copper-Induced Oxidative Stress Response in Arabidopsis thaliana

Non-Coding RNA
Recently, post-transcriptional regulation of mRNA mediated by N6-methyladenosine (m6A) has been found to have profound effects on transcriptome regulation during plant responses to various abiotic stresses.
Bishwas Sharma, Ganesan Govindan, Yongfang Li, Ramanjulu Sunkar, Brian D. Gregory   +4 more
doaj   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, Volume 13, Issue 18, 27 March 2026.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source