Results 91 to 100 of about 4,508 (221)

High-throughput identification of C/D box snoRNA targets with CLIP and RiboMeth-seq [PDF]

, 2016
High-throughput sequencing has greatly facilitated the discovery of long and short non-coding RNAs (ncRNAs), which frequently guide ribonucleoprotein complexes to RNA targets, to modulate their metabolism and expression.
Gumienny, Rafal, Gypas, Foivos, Jedlinski, Dominik J., Martin, Georges, Schmidt, Alexander, Vina-Vilaseca, Arnau, Zavolan, Mihaela   +6 more
core   +1 more source

Decoding co-/post-transcriptional complexities of plant transcriptomes and epitranscriptome using next-generation sequencing technologies [PDF]

, 2020
Next-generation sequencing (NGS) technologies – Illumina RNA-seq, Pacific Biosciences isoform sequencing (PacBio Iso-seq), and Oxford Nanopore direct RNA sequencing (DRS) - have revealed the complexity of plant transcriptomes and their regulation at the ...
Ben-Hur, A., Ben-Hur, A., Dong, S., Dong, S., Gu, L., Gu, L., Huang, J., Huang, J., Reddy, A. S. N., Reddy, A. S. N., Syed, N., Syed, N.   +11 more
core   +1 more source

WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A‐Dependent Regulation of TP53BP1

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Periodontitis, a chronic inflammatory disease, represents the primary cause of tooth loss in Chinese adults. Wilms tumor 1‐associating protein (WTAP) is a key component of the N6‐methyladenosine (m6A) methyltransferase complex, and has an unclear role in periodontitis pathogenesis, particularly concerning its regulatory functions in
Menglin Xiong, Tingting Wang, Yuan Liu
wiley   +1 more source

Loss of METTL3 m6A methyltransferase results in short‐term progression and poor treatment outcome of bladder cancer patients

International Journal of Cancer, Volume 158, Issue 3, Page 763-774, 1 February 2026.
What's new? Bladder cancer exhibits a highly heterogeneous molecular landscape and treatment response. The dysregulation of RNA modifications such as m6A has been involved in cancer initiation and progression. This study comprehensively analyzed the expression of the main catalytic component of the m6A methylation machinery in bladder tumors across one
Katerina‐Marina Pilala, Stella Koroneou, Maria‐Alexandra Papadimitriou, Konstantina Panoutsopoulou, Konstantinos Soureas, Georgios‐Christos Giagkos, Panagiotis Levis, Dimitrios Linardoutsos, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas   +10 more
wiley   +1 more source

Modifying gene expression through passive forces

eLife
The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.
Sarah Hallstein, Julian König
doaj   +1 more source

Getting the Entire Message: Progress in Isoform Sequencing

Frontiers in Genetics, 2019
The advent of second-generation sequencing and its application to RNA sequencing have revolutionized the field of genomics by allowing quantification of gene expression, as well as the definition of transcription start/end sites, exons, splice sites and ...
Simon A. Hardwick, Simon A. Hardwick, Anoushka Joglekar, Paul Flicek, Adam Frankish, Hagen U. Tilgner   +5 more
doaj   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Epitranscriptomic code and its alterations in human disease [PDF]

, 2018
Innovations in epitranscriptomics have resulted in the identification of more than 160 RNA modifications to date. These developments, together with the recent discovery of writers, readers, and erasers of modifications occurring across a wide range of ...
Janga, Sarath Chandra, Kadumuri, Rajashekar Varma   +1 more
core   +1 more source

Single-cell analysis of the epitranscriptome: RNA modifications under the microscope

RNA Biology
The identification of mechanisms capable of modifying genetic information by the addition of covalent RNA modifications distinguishes a level of complexity in gene expression which challenges key long-standing concepts of RNA biology.
Eva Crespo-García, Alberto Bueno-Costa, Manel Esteller   +2 more
doaj   +1 more source

Deciphering mRNA Translation During Sperm Capacitation: A New Frontier in Fertility Research

Molecular Reproduction and Development, Volume 93, Issue 2, February 2026.
ABSTRACT Male infertility accounts for approximately 50% of infertility cases, with nearly 30% remaining unexplained after standard evaluations. This highlights the need for a better understanding of sperm function to advance diagnostic and therapeutic strategies. Sperm were long considered translationally quiescent; however, emerging evidence suggests
Saurabh Tiwari, Nehal Thakor, Jacob Thundathil   +2 more
wiley   +1 more source