Results 91 to 100 of about 3,547 (209)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Clinical Perspectives in Epitranscriptomics

Current Opinion in Genetics & Development
Epitranscriptomics, the study of reversible and dynamic chemical marks on the RNA, is rapidly emerging as a pivotal field in post-transcriptional gene expression regulation. Increasing knowledge about epitranscriptomic landscapes implicated in disease pathogenesis proves an invaluable opportunity for the identification of epitranscriptomic biomarkers ...
Eloy Santos-Pujol, Carlos Quero-Dotor, Manel Esteller   +2 more
openaire   +2 more sources

Plant ribosomes as a score to fathom the melody of 2’-O-methylation across evolution

RNA Biology
2’-O-ribose methylation (2’-O-Me) is one of the most common RNA modifications detected in ribosomal RNAs (rRNA) from bacteria to eukaryotic cells. 2’-O-Me favours a specific RNA conformation and protects RNA from hydrolysis.
Sara Alina Neumann, Christine Gaspin, Julio Sáez-Vásquez   +2 more
doaj   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, Volume 13, Issue 18, 27 March 2026.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Roadmap to the epitranscriptome [PDF]

Science, 2014
N 6 -methyl-adenosine signals the way and YTH proteins respond
openaire   +1 more source

The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial

Frontiers in Immunology
BackgroundEpitranscriptomics, with m6A as the most prevalent in mammals, is a novel treatment target for inflammatory diseases, including cardiovascular diseases.
Tuva B. Dahl, Tuva B. Dahl, Ana Quiles-Jiménez, Kaspar Broch, Kaspar Broch, Anne Kristine Anstensrud, Anne Kristine Anstensrud, Lars Gullestad, Lars Gullestad, Lars Gullestad, Geir Ø. Andersen, Geir Ø. Andersen, Ola Kleveland, Jonas Øgaard, Jonas Øgaard, Vigdis Bjerkeli, Vigdis Bjerkeli, Azita Rashidi, Kuan Yang, Kirsten B. Holven, Kirsten B. Holven, Pål Aukrust, Magnar Bjørås, Magnar Bjørås, Camilla Huse, Camilla Huse, Camilla Huse, Bente Halvorsen, Bente Halvorsen   +28 more
doaj   +1 more source

An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization

Cells, 2019
Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast, Paul H.A. Quax, A. Yaël Nossent   +2 more
doaj   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Image3_The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.TIF

, 2022
The microbiome exerts profound effects on fetal development and health, yet the mechanisms underlying remain elusive. N6-methyladenosine (m6A) plays important roles in developmental regulation.
Zhuoyu Xiao (12834362), Sun Liu (474179), Zihan Wang (3129810), Laixin Xia (373554), Zengguang Li (5082146), Yuan Li (67017), Qihuan Ren (13010052), Jinru Cui (13010049), Hailan Wang (309789), Zhijian Wang (310214)   +9 more
core   +1 more source

Image4_The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.TIF

, 2022
The microbiome exerts profound effects on fetal development and health, yet the mechanisms underlying remain elusive. N6-methyladenosine (m6A) plays important roles in developmental regulation.
Zhuoyu Xiao (12834362), Sun Liu (474179), Zihan Wang (3129810), Laixin Xia (373554), Zengguang Li (5082146), Yuan Li (67017), Qihuan Ren (13010052), Jinru Cui (13010049), Hailan Wang (309789), Zhijian Wang (310214)   +9 more
core   +1 more source