Results 81 to 90 of about 3,547 (209)

Interplay of RNA m6A/m1A/m5C/m7G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
In this study, we comprehensively analyze the 64 RNA modification regulators, including 24 m6A regulators, 13 m1A regulators, 12 m5C regulators, 9 m7G regulators, and 12 pseudouridine regulators in pancreatic cancer in TCGA, GTEx, and HPA databases. We investigate their RNA and protein expression, their association with patients' clinical significance,
Shiyin Chen, Jiawei Mao, Lin Xu, Linbei Lu, Yajuan Hao   +4 more
wiley   +1 more source

The 5‐Methylcytosine RNA Modification in Hepatitis B Virus‐Negative Hepatocellular Carcinoma: Insights From Long‐Read Nanopore Sequencing

Molecular Carcinogenesis, Volume 65, Issue 4, Page 397-406, April 2026.
ABSTRACT 5‐Methylcytosine (m5C) RNA modification contributes to tumor initiation and progression. However, its transcriptome‐wide distribution patterns and biological implications in hepatitis B virus (HBV)‐negative hepatocellular carcinoma (HCC) remain poorly understood.
Tianhan Sun, Liying Zhou, XiaoQing Li, Ryan Xiao, Gaoyuan Sun, Lili Zhang, Yifei Li, Wei Huang, Yayu Li, Lu Kuai, Xuanmei Luo, Hongyuan Cui, Meng Chen   +12 more
wiley   +1 more source

The art of Epitranscriptomics

International Physical Medicine & Rehabilitation Journal, 2022
https://orcid.org/0000-0002-3292 ...
openaire   +1 more source

Epitranscriptome: A Novel Regulatory Layer during Atherosclerosis Progression

RNA modifications have recently gained great attention due to their extensive regulatory effects in a wide range of cellular networks and signaling pathways.
Schiano, Concetta, Infante, Teresa, Napoli, Claudio, Coppola, Annapaola, de Nigris, Filomena, Coscioni, Enrico, Trama, Ugo   +6 more
core   +1 more source

Adductomic Approach to Evaluate the Epitranscriptome and Disease [PDF]

, 2021
Chemical modifications on RNA play critical roles in post-transcriptional gene regulation. Like DNA epigenetic modifications, e.g., 5-methyl-2’-deoxycytidine (5-mdC) and 5-hydroxymethyl-2’-deoxycytidine (5-hmdC), they provide an additional layer of ...
Gonzalez, Gwendolyn Michelle
core  

Modifying gene expression through passive forces

eLife
The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.
Sarah Hallstein, Julian König
doaj   +1 more source

Getting the Entire Message: Progress in Isoform Sequencing

Frontiers in Genetics, 2019
The advent of second-generation sequencing and its application to RNA sequencing have revolutionized the field of genomics by allowing quantification of gene expression, as well as the definition of transcription start/end sites, exons, splice sites and ...
Simon A. Hardwick, Simon A. Hardwick, Anoushka Joglekar, Paul Flicek, Adam Frankish, Hagen U. Tilgner   +5 more
doaj   +1 more source

Single‐Cell and Spatial Omics: Methods and Applications

MedComm, Volume 7, Issue 4, April 2026.
Systematically summarized the breakthrough sequencing technologies and computational methods for single‐cell and spatial omics across multiple omics layers, including genome, epigenome, transcriptome, proteome, and metabolome. State‐of‐the‐art methods for multi‐omics integration, cross‐modal integration, and cross‐scale integration were reviewed, with ...
Xiaoping Cen, Xiaolan Huang, Enjin Deng, Xue Gong, Na Tan, Jifeng Ye, Yin Wang, Roland Eils, Qun Luo, Yixue Li, Fangfang Qu   +10 more
wiley   +1 more source

The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic β-Cell Failure

, 2019
tRNAs are crucial noncoding RNA molecules that serve as amino acid carriers during protein synthesis. The transcription of tRNA genes is a highly regulated process.
Igoillo Esteve, Mariana, Cnop, Miriam, Cosentino, Cristina   +2 more
core   +1 more source

Single-cell analysis of the epitranscriptome: RNA modifications under the microscope

RNA Biology
The identification of mechanisms capable of modifying genetic information by the addition of covalent RNA modifications distinguishes a level of complexity in gene expression which challenges key long-standing concepts of RNA biology.
Eva Crespo-García, Alberto Bueno-Costa, Manel Esteller   +2 more
doaj   +1 more source