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PathoRM: Computational inference of pathogenic RNA methylation sites by incorporating multi-view features. [PDF]
PLoS Computational BiologyIdentifying pathogenic RNA methylation sites with a reasonable biological explanation has important implications for the treatment of diseases. Due to the limitations of in vitro experiments in identifying pathogenic RNA methylation sites, there is a ...
Hui Liu, Jiani Ma, Xianjun Ma, Lin Zhang
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Effects of RNA methylation on Tumor angiogenesis and cancer progression
Molecular Cancer, 2023 Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA methylation is one of the most common modifications and is widely observed in eukaryotes and prokaryotes. Accumulating studies have revealed that RNA methylation affects the
Mingyu Han +6 more
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RNA methylation in plants: An overview
Frontiers in Plant Science, 2023 RNA methylation is an important post-transcriptional modification that influences gene regulation. Over 200 different types of RNA modifications have been identified in plants. In animals, the mystery of RNA methylation has been revealed, and its biological role and applications have become increasingly clear.
Harshraj Shinde +4 more
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Emerging roles of RNA methylation in gastrointestinal cancers
Cancer Cell International, 2020 RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression ...
Shanshan Xie +8 more
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Clinical significance of RNA methylation in hepatocellular carcinoma
Cell Communication and SignalingHepatocellular carcinoma (HCC) is a primary liver malignancy with high mortality rates and poor prognosis. Recent advances in high-throughput sequencing and bioinformatic technologies have greatly enhanced the understanding of the genetic and epigenetic ...
Qiongling Bao +6 more
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Multiple functions of m6A RNA methylation in cancer
Journal of Hematology & Oncology, 2018 First identified in 1974, m6A RNA methylation, which serves as a predominant internal modification of RNA in higher eukaryotes, has gained prodigious interest in recent years. Modifications of m6A are dynamic and reversible in mammalian cells, which have
Yutian Pan +4 more
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The diverse role of RNA methylation in esophageal cancer
Acta Biochimica et Biophysica Sinica, 2023 Esophageal cancer is one of the major life-threatening diseases in the world. RNA methylation is the most common post-transcriptional modification and a wide-ranging regulatory system controlling gene expression.
Meng Wangyang +3 more
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Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation [PDF]
Cell GenomicsSummary: As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms.
Haozhe Wang +10 more
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Advances in research on RNA methylation and cancer radiotherapy resistance [PDF]
Frontiers in OncologyRNA methylation is a type of reversible chemical modification in epitranscriptomics that influences gene expression by dynamically regulating RNA functions.
Hui Liu +5 more
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The role of RNA methylation in tumor immunity and its potential in immunotherapy
Molecular CancerRNA methylation, a prevalent post-transcriptional modification, has garnered considerable attention in research circles. It exerts regulatory control over diverse biological functions by modulating RNA splicing, translation, transport, and stability ...
Yan Li +5 more
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