Results 11 to 20 of about 1,130,807 (299)
The RNAs of RNA-directed DNA methylation [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2017 RNA-directed chromatin modification that includes cytosine methylation silences transposable elements in both plants and mammals, contributing to genome defense and stability. In Arabidopsis thaliana, most RNA-directed DNA methylation (RdDM) is guided by small RNAs derived from double-stranded precursors synthesized at cytosine-methylated loci by ...
Jered M, Wendte, Craig S, Pikaard
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Identification and characterisation of MORC6 as a component of the RNA-directed DNA methylation pathway in Arabidopsis thaliana [PDF]
, 2012 RNA silencing pathways control the expression of genes and other DNA loci by the action of small RNA molecules and are found in many eukaryotes. In plants there are a number of RNA silencing pathways, of which RNA-directed DNA methylation (RdDM) is one ...
Brabbs, Thomas
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RNA methylation and cancer treatment
Pharmacological Research, 2021 To this date, over 100 different types of RNA modification have been identified. Methylation of different RNA species has emerged as a critical regulator of transcript expression. RNA methylation and its related downstream signaling pathways are involved in plethora biological processes, including cell differentiation, sex determination and stress ...
Baochen, Yang +5 more
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RNA Methylation Clears the Way [PDF]
Developmental Cell, 2017 During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but interrelated pathways. A recent study in Nature by Zhao et al. (2017) finds that YTHDF2, a reader of N6- methylation, facilitates maternal mRNA decay, introducing an additional facet of control over transcript fate and developmental reprogramming.
Cassandra, Kontur, Antonio, Giraldez
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RNA-directed DNA methylation [PDF]
Current Opinion in Plant Biology, 2011 DNA methylation is an important epigenetic mechanism for silencing transposons and other repetitive elements, and for stable repression of specific transgenes and endogenous genes. Plants can utilize small interfering RNAs (siRNAs) to guide de novo DNA methyltransferases for the establishment of sequence-specific DNA methylation.
Huiming, Zhang, Jian-Kang, Zhu
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Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]
, 2010 For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
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Detection and analysis of RNA methylation [PDF]
F1000Research, 2019 Our understanding of the expanded genetic alphabet has been growing rapidly over the last two decades, and many of these developments came more than 80 years after the original discovery of a modified guanine in tuberculosis DNA. These new understandings, leading to the field of epigenetics, have led to exciting new fundamental and applied knowledge ...
Nigel P. Mongan +2 more
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Bibliometric and visual analysis of RAN methylation in cardiovascular disease
Frontiers in Cardiovascular Medicine, 2023 BackgroundRNA methylation is associated with cardiovascular disease (CVD) occurrence and development. The purpose of this study is to visually analyze the results and research trends of global RNA methylation in CVD.MethodsArticles and reviews on RNA ...
Boce Song +7 more
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Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I [PDF]
, 2010 Mammalian cleavage factor I (CF Im) is composed of two polypeptides of 25 kDa and either a 59 or 68 kDa subunit (CF Im25, CF Im59, CF Im68). It is part of the cleavage and polyadenylation complex responsible for processing the 39 ends of messenger RNA ...
Antje Ostareck-Lederer +26 more
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MedComm – Future Medicine, 2023 RNA methylation plays a key role across biological processes, which could be utilized as new weapons for cancer management. However, the implication of RNA methylation regulators in cancers, especially in clear cell renal cell cancer (ccRCC), remains ...
Aimin Jiang +12 more
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