Results 11 to 20 of about 248,618 (295)

RNA methylation in urological cancers: regulatory logic, biological functions, and clinical relevance [PDF]

Frontiers in Immunology
Urological malignancies, including prostate, bladder, and renal cancers, remain a major clinical challenge because of tumor heterogeneity, disease progression, and therapeutic resistance.
Jiahao Peng, Chong Xie, Zhangmin Xie, Feng Tang, Zhiying Wang, Minhao Liu, Li Yu, Chenhao Tang, Ziyang Liu, Zuowei Yuan, Longwei Liao, Xinpan Zou, Xuran Liu, Mingyang Yi, Huangheng Tao, Wei Wei, Tao Liu, Yixiang Liao   +17 more
doaj   +2 more sources

Advances in research on RNA methylation and its role in the immune microenvironment of gastrointestinal tumors [PDF]

Frontiers in Cell and Developmental Biology
RNA methylation is a key epigenetic regulatory mechanism that precisely regulates gene expression through the dynamic and reversible actions of “Writers,” “Erasers” and “Readers”.
Yushuo Duan, Ziyi Xu, Kaixiang Wen, Chen Xue, Ruile Shen, Xinyu Gu   +5 more
doaj   +2 more sources

Regulation of RNA methylation linked to drug resistance in gastric cancer [PDF]

Frontiers in Cell and Developmental Biology
In global terms, gastric cancer (GC) represents one of the most commonly occurring malignancies. It is positioned as the fifth most frequent cancer in terms of incidence and stands as the third primary contributor to cancer-related mortality.
Zihan Yang, Yanpin Ma, Ziyi Xu, Hongyan Liu, Xinyu Gu, Jiachun Sun   +5 more
doaj   +2 more sources

Using integrated analysis from multicentre studies to identify RNA methylation-related lncRNA risk stratification systems for glioma

Cancer Cell International, 2023
Background N6-methyladenosine (m6A), 5-methylcytosine (m5C) and N1-methyladenosine (m1A) are the main RNA methylation modifications involved in the progression of cancer.
Fanxuan Huang, Xinyu Wang, Junzhe Zhong, Hao Chen, Dan Song, Tianye Xu, Kaifu Tian, Penggang Sun, Nan Sun, Jie Qin, Yu Song, Wenbin Ma, Yuxiang Liu, Daohan Yu, Xiangqi Meng, Chuanlu Jiang, Hanwen Xuan, Da Qian, Jinquan Cai   +18 more
doaj   +2 more sources

Single-cell analysis reveal cell-type-specific RNA methylation patterns in breast cancer [PDF]

Journal of International Medical Research
Objective This study aimed to investigate cell-type-specific RNA methylation patterns in primary breast cancers and metastatic lymph nodes and explore their roles in cancer progression and immune regulation.
Shengtao Huang, Yichen Lin, Xiaobing Liu, Kun Zhang, Qiuju Han, Ruilei Liu, Yong Zhuang   +6 more
doaj   +2 more sources

The RNA methylation modification as an immunometabolic regulatory hub in pancreatic cancer: from mechanistic insights to clinical translation perspectives [PDF]

Molecular Cancer
RNA methylation represents the most abundant post-transcriptional modification in RNA and has recently emerged as a central topic in molecular biology.
Yinghao Zhu, Kai Ma, Qisheng Hao, Kang Fu, Faxian Hei, Ning Sun, Zhiguo Yin, Weidong Guo, Hao Zou, Zhen Tan   +9 more
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RNA methylation in neurodevelopment and related diseases [PDF]

Acta Biochimica et Biophysica Sinica
Biological development and genetic information transfer are governed by genetic, epigenetic, transcriptional, and posttranscriptional mechanisms. RNA methylation, the attachment of methyl (-CH 3) groups to RNA molecules, is a posttranscriptional modification that has gained increasing attention in recent years because of its role in RNA ...
Xia Wenjuan, Liu Yue, Lu Jiafeng, Cheung Hoi-Hung, Meng Qingxia, Huang Boxian   +5 more
openaire   +4 more sources

Construction and validation of m6A RNA methylation regulators associated prognostic model for gastrointestinal cancer

IET Systems Biology, 2022
N6‐methyladenosine (m6A) RNA methylation is correlated with carcinogenesis and dynamically possessed through the m6A RNA methylation regulators. This paper aimed to explore 13 m6A RNA methylation regulators' role in gastrointestinal cancer (GIC) and ...
Yandong Miao, Bin Su, Xiaolong Tang, Jiangtao Wang, Wuxia Quan, Yonggang Chen, Denghai Mi   +6 more
doaj   +1 more source

The RNAs of RNA-directed DNA methylation [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2017
RNA-directed chromatin modification that includes cytosine methylation silences transposable elements in both plants and mammals, contributing to genome defense and stability. In Arabidopsis thaliana, most RNA-directed DNA methylation (RdDM) is guided by small RNAs derived from double-stranded precursors synthesized at cytosine-methylated loci by ...
Jered M, Wendte, Craig S, Pikaard
openaire   +2 more sources

RNA methylation and cancer treatment

Pharmacological Research, 2021
To this date, over 100 different types of RNA modification have been identified. Methylation of different RNA species has emerged as a critical regulator of transcript expression. RNA methylation and its related downstream signaling pathways are involved in plethora biological processes, including cell differentiation, sex determination and stress ...
Baochen, Yang, Jing-Quan, Wang, Yao, Tan, Runzhu, Yuan, Zhe-Sheng, Chen, Chang, Zou   +5 more
openaire   +2 more sources