Results 31 to 40 of about 1,130,807 (299)
2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase. [PDF]
PLoS Pathogens, 2012 RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2'-O methyltransferase activities that are required for the formation of 5' type I cap (m(7)GpppAm) of viral RNA genome.
Hongping Dong +10 more
doaj +1 more source
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan [PDF]
, 2015 Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear.
Wilson, Iain B H +31 more
core +2 more sources
Computational discovery of animal small RNA genes and targets [PDF]
, 2007 Though recently discovered, small RNAs appear to play a wealth of regulatory roles, being involved in degradation of target mRNAs, translation silencing of target genes, chromatin remodeling and transposon silencing.
Gaidatzis, Dimosthenis
core +1 more source
Journal of Inflammation Research, 2022 Xin-Yu Li,1,2 Xi-Tao Yang1 1Department of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Department of Neurosurgery, Shanghai ...
Li XY, Yang XT
doaj
Integration of multi-omics data reveals dysregulated RNA methylation in retinal pigment epithelium drives age-related macular degeneration [PDF]
International Journal of OphthalmologyAIM: To investigate the role of RNA methylation in retinal pigment epithelial (RPE) cells in age-related macular degeneration (AMD). METHODS: RNA methylation-related gene expression profiles of AMD patient and normal control retinal pigment epithelium ...
Ya-Jun Gong +4 more
doaj +1 more source
Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]
, 2007 Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea +7 more
core +1 more source
PLOS Genetics, 2020 RNA-directed DNA methylation (RdDM) is a biological process in which non-coding RNA molecules direct the addition of DNA methylation to specific DNA sequences. The RdDM pathway is unique to plants, although other mechanisms of RNA-directed chromatin modification have also been described in fungi and animals.
Robert M. Erdmann, Colette L. Picard
openaire +4 more sources
RNA interference-mediated co-transcriptional gene silencing in fission yeast [PDF]
, 2012 In the last decade or so, RNA interference (RNAi) has gained unanticipated recognition in the fields of RNA biology and gene regulation. It exists in a wide variety of eukaryotic organisms, and various forms of RNAi are involved in diverse biological ...
Woolcock, Katrina Jane
core +1 more source
Frontiers in Pharmacology, 2022 N6-methyladenosine (m6A) RNA methylation has been considered the most prevalent, abundant, and conserved internal transcriptional modification throughout the eukaryotic mRNAs.
Zhaolin Chen +7 more
doaj +1 more source
Epigenetic and genomic biomarker discovery in breast cancer [PDF]
, 2011 Breast cancer is the most common malignancy among females and the fifth most common cause of cancer death worldwide. The research for biomarker discovery for the diagnosis and prognosis of patients with breast cancer has been going on for decades ...
Radpour, Ramin
core +1 more source