Results 1 to 10 of about 8,119 (209)

M5C-driven stabilization of SERPINB5 promotes cervical cancer progression and chemotherapy resistance [PDF]

Cell Death and Disease
RNA 5-methylcytosine (m5C) plays a critical role in cancer, yet its functional mechanisms and therapeutic relevance in cervical cancer remain unclear.
Jiejie Liu, Limin Zhou, Peipei Yao, Nan Zhang, Xiao Guo, Fei Chen, Shimin Yang, Xin Du, Hongyun Wang, You Zhou, Yu Chen, Li Zhou   +11 more
doaj   +4 more sources

Modification of m5C regulators in sarcoma can guide different immune infiltrations as well as immunotherapy [PDF]

Frontiers in Surgery, 2023
BackgroundRecent studies have found that 5-methylcytosine (m5C) modulators are associated with the prognosis and treatment of cancer. However, the relevance of m5C modulators in sarcoma prognosis and the tumour microenvironment is unclear.MethodsWe ...
Shusheng Wu, Mengge Li, Rixin Su, Hao Shen, Yifu He, Yangfan Zhou   +5 more
doaj   +2 more sources

NSUN2‐mediated m5C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression

Clinical and Translational Medicine, 2023
Background The precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism, and is necessary for the maintenance of epigenome homeostasis.
Sipeng Zuo
exaly   +2 more sources

NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2-Dependent Stabilisation of SCD1 m5C Methylation. [PDF]

Adv Sci (Weinh)
NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Song XX, Suo XG, Yu Y, Zhang K, Li CA, Wang J, Xu HX, Niu SY, Lv DX, He ZH, Li FH, Meng XM, Jin J.   +12 more
europepmc   +2 more sources

Comprehensive Analysis of m5C Methylation Regulatory Genes and Tumor Microenvironment in Prostate Cancer

Frontiers in Immunology, 2022
Background5-Methylcytidine (m5C) methylation is an emerging epigenetic modification in recent years, which is associated with the development and progression of various cancers.
Guopeng Yu, Jiahao Bao, Shangqing Song   +2 more
exaly   +3 more sources

m5C RNA Methylation Primarily Affects the ErbB and PI3K–Akt Signaling Pathways in Gastrointestinal Cancer

Frontiers in Molecular Biosciences, 2020
5-Methylcytosine (m5C) is a kind of methylation modification that occurs in both DNA and RNA and is present in the highly abundant tRNA and rRNA. It has an important impact on various human diseases including cancer.
Shixin Xiang, Yongshun Ma, Ｊing Shen   +2 more
exaly   +3 more sources

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment. [PDF]

MedComm (2020)
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Li Q, Sun Y, Lin S, Yuan Q.
europepmc   +2 more sources

Comprehensive Analysis of 5-Methylcytosine (m5C) Regulators and the Immune Microenvironment in Pancreatic Adenocarcinoma to Aid Immunotherapy

Frontiers in Oncology, 2022
BackgroundPancreatic adenocarcinoma (PAAD) is one of the most malignant cancers and has a poor prognosis. As a critical RNA modification, 5-methylcytosine (m5C) has been reported to regulate tumor progression, including PAAD progression.
Ronglin Wang, Yongdong Guo, Peixiang Ma, Yang Song, Jie Min, Ting Zhao, Lei Hua, Chao Zhang, Cheng Yang, Jingjie Shi, Liaoliao Zhu, Dongxue Gan, Shanshan Li, Junqiang Li, Haichuan Su   +14 more
doaj   +1 more source

m5C Regulator-mediated methylation modification clusters contribute to the immune microenvironment regulation of multiple myeloma

Frontiers in Genetics, 2022
Background: Multiple myeloma (MM) is a hematological malignancy in which plasma cells proliferate abnormally. 5-methylcytosine (m5C) methylation modification is the primary epigenetic modification and is involved in regulating the occurrence, development,
Hefei Ren, Chang Liu, Hongkun Wu, Zhenhua Wang, Sai Chen, Xiaomin Zhang, Jigang Ren, Huiying Qiu, Lin Zhou   +8 more
doaj   +1 more source

RNA Modification in Carcinogenesis and Development of Gastric Cancer

Zhongliu Fangzhi Yanjiu, 2023
The occurrence of gastric cancer is closely related to environmental, genetic, and epigenetic factors. Currently, RNA modification is a research frontier and hotspot in the field of epigenetics.
XU Jiawen, WANG Qiang, WANG Shouyu
doaj   +1 more source