Results 1 to 10 of about 11,252 (152)

NSUN2‐mediated m5C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression

Clinical and Translational Medicine, 2023
Background The precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism, and is necessary for the maintenance of epigenome homeostasis.
Xianqun Fan, Xianqun Fan
exaly   +2 more sources

Comprehensive Analysis of m5C Methylation Regulatory Genes and Tumor Microenvironment in Prostate Cancer

Frontiers in Immunology, 2022
Background5-Methylcytidine (m5C) methylation is an emerging epigenetic modification in recent years, which is associated with the development and progression of various cancers.
Guopeng Yu, Jiahao Bao, Ming Zhan, Jiangyi Wang, Xinjuan Li, Xin Gu, Shangqing Song, Qing Yang, Yushan Liu, Zhong Wang, Bin Xu   +10 more
exaly   +3 more sources

m5C RNA Methylation Primarily Affects the ErbB and PI3K–Akt Signaling Pathways in Gastrointestinal Cancer

Frontiers in Molecular Biosciences, 2020
5-Methylcytosine (m5C) is a kind of methylation modification that occurs in both DNA and RNA and is present in the highly abundant tRNA and rRNA. It has an important impact on various human diseases including cancer.
Yueshui Zhao, Xu Wu, Mingxing Li
exaly   +3 more sources

M5C-driven stabilization of SERPINB5 promotes cervical cancer progression and chemotherapy resistance [PDF]

Cell Death and Disease
RNA 5-methylcytosine (m5C) plays a critical role in cancer, yet its functional mechanisms and therapeutic relevance in cervical cancer remain unclear.
Jiejie Liu, Limin Zhou, Peipei Yao, Nan Zhang, Xiao Guo, Fei Chen, Shimin Yang, Xin Du, Hongyun Wang, You Zhou, Yu Chen, Li Zhou   +11 more
doaj   +2 more sources

RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression [PDF]

npj Precision Oncology
5-methylcytosine (m5C) RNA modification plays critical roles in post-transcriptional regulation and cancer progression. However, the downstream effectors of the m5C reader protein YBX1 and their mechanistic contribution to hepatocellular carcinoma (HCC ...
Jianhao Li, Han Chen, Lang Bai, Hong Tang   +3 more
doaj   +2 more sources

Comprehensive Analysis of 5-Methylcytosine (m5C) Regulators and the Immune Microenvironment in Pancreatic Adenocarcinoma to Aid Immunotherapy

Frontiers in Oncology, 2022
BackgroundPancreatic adenocarcinoma (PAAD) is one of the most malignant cancers and has a poor prognosis. As a critical RNA modification, 5-methylcytosine (m5C) has been reported to regulate tumor progression, including PAAD progression.
Ronglin Wang, Yongdong Guo, Peixiang Ma, Yang Song, Jie Min, Ting Zhao, Lei Hua, Chao Zhang, Cheng Yang, Jingjie Shi, Liaoliao Zhu, Dongxue Gan, Shanshan Li, Junqiang Li, Haichuan Su   +14 more
doaj   +1 more source

Modification of m5C regulators in sarcoma can guide different immune infiltrations as well as immunotherapy

Frontiers in Surgery, 2023
BackgroundRecent studies have found that 5-methylcytosine (m5C) modulators are associated with the prognosis and treatment of cancer. However, the relevance of m5C modulators in sarcoma prognosis and the tumour microenvironment is unclear.MethodsWe ...
Shusheng Wu, Mengge Li, Rixin Su, Hao Shen, Yifu He, Yangfan Zhou   +5 more
doaj   +1 more source

m5C Regulator-mediated methylation modification clusters contribute to the immune microenvironment regulation of multiple myeloma

Frontiers in Genetics, 2022
Background: Multiple myeloma (MM) is a hematological malignancy in which plasma cells proliferate abnormally. 5-methylcytosine (m5C) methylation modification is the primary epigenetic modification and is involved in regulating the occurrence, development,
Hefei Ren, Chang Liu, Hongkun Wu, Zhenhua Wang, Sai Chen, Xiaomin Zhang, Jigang Ren, Huiying Qiu, Lin Zhou   +8 more
doaj   +1 more source

RNA Modification in Carcinogenesis and Development of Gastric Cancer

Zhongliu Fangzhi Yanjiu, 2023
The occurrence of gastric cancer is closely related to environmental, genetic, and epigenetic factors. Currently, RNA modification is a research frontier and hotspot in the field of epigenetics.
XU Jiawen, WANG Qiang, WANG Shouyu
doaj   +1 more source

Radio Timing and Optical Photometry of the Black Widow System PSR J1953+1846A in the Globular Cluster M71 [PDF]

, 2015
We report on the determination of the astrometric, spin and orbital parameters for PSR J1953+1846A, a "black widow" binary millisecond pulsar in the globular cluster M71.
Cadelano, M., Dales, Ferraro, F., Freire, P., Hessels, J., Lanzoni, B., Pallanca, C., Ransom, S., ro, E., Stairs, I.   +9 more
core   +10 more sources