Results 11 to 20 of about 7,626 (175)
Detection, molecular function and mechanisms of m5C in cancer
Clinical and Translational MedicineInterest in RNA posttranscriptional modifications, particularly 5‐methylcytosine (m5C), has surged in recent years. Studies have shown that m5C plays a key role in cellular processes and is closely linked to tumourigenesis.
Linhui Zhang +6 more
doaj +3 more sources
m<sup>5</sup>C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6-Mediated Wnt/β-catenin Signaling Pathway. [PDF]
Adv Sci (Weinh)This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Hao L +8 more
europepmc +2 more sources
NSUN2-Mediated m<sup>5</sup>C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA. [PDF]
Adv Sci (Weinh)NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Zhu X +10 more
europepmc +2 more sources
m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets
Journal of Translational Medicine5-Methylcytosine (m5C), an important RNA modification, has been extensively studied in colorectal cancer (CRC). In recent years, with advances in high-throughput sequencing technology and RNA modification detection tools, the role of m5C modification in ...
Jiawei Wang +5 more
doaj +3 more sources
Protocol for profiling RNA m5C methylation at base resolution using m5C-TAC-seq
STAR ProtocolsSummary: RNA 5-methylcytosine (m5C) is a widespread modification and plays a crucial role in gene expression regulation. Here, we present a protocol for transcriptome-wide m5C methylome profiling at base resolution using bisulfite-free m5C detection ...
Xiaoting Zhang +3 more
doaj +3 more sources
YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2-m5C Modified ATF4 mRNA. [PDF]
Cancer SciThe diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Li Y, Li S, Li Y, Pan Z.
europepmc +2 more sources
The role of m5C methyltransferases in cardiovascular diseases
Frontiers in Cardiovascular Medicine, 2023 The global leading cause of death is cardiovascular disease (CVD). Although advances in prevention and treatment have been made, the role of RNA epigenetics in CVD is not fully understood. Studies have found that RNA modifications regulate gene expression in mammalian cells, and m5C (5-methylcytosine) is a recently discovered RNA modification that ...
Yan-Yue Wang +6 more
openaire +3 more sources
Cell Host & Microbe, 2019 In this issue of Cell Host & Microbe, Courtney et al. (2019a) find that HIV-1 genomic RNA has much more m5C than cellular mRNA. Deleting the m5C "writer" NSUN2 decreases HIV-1 m5C levels, promotes translation of the HIV-1 5' gag gene, and alters splicing at the A2 site.
Shelby, Winans, Karen, Beemon
openaire +2 more sources
A CNN based m5c RNA methylation predictor
Scientific Reports, 2023 AbstractPost-transcriptional modifications of RNA play a key role in performing a variety of biological processes, such as stability and immune tolerance, RNA splicing, protein translation and RNA degradation. One of these RNA modifications is m5c which participates in various cellular functions like RNA structural stability and translation efficiency,
Irum Aslam +6 more
openaire +3 more sources
m5C-Atlas: a comprehensive database for decoding and annotating the 5-methylcytosine (m5C) epitranscriptome [PDF]
Nucleic Acids Research, 2021 Abstract 5-Methylcytosine (m5C) is one of the most prevalent covalent modifications on RNA. It is known to regulate a broad variety of RNA functions, including nuclear export, RNA stability and translation. Here, we present m5C-Atlas, a database for comprehensive collection and annotation of RNA 5-methylcytosine.
Jiongming Ma +9 more
openaire +3 more sources