Results 11 to 20 of about 8,119 (209)
Protocol for profiling RNA m5C methylation at base resolution using m5C-TAC-seq
STAR ProtocolsSummary: RNA 5-methylcytosine (m5C) is a widespread modification and plays a crucial role in gene expression regulation. Here, we present a protocol for transcriptome-wide m5C methylome profiling at base resolution using bisulfite-free m5C detection ...
Xiaoting Zhang +3 more
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m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets
Journal of Translational Medicine5-Methylcytosine (m5C), an important RNA modification, has been extensively studied in colorectal cancer (CRC). In recent years, with advances in high-throughput sequencing technology and RNA modification detection tools, the role of m5C modification in ...
Jiawei Wang +5 more
doaj +4 more sources
m5C-Atlas: a comprehensive database for decoding and annotating the 5-methylcytosine (m5C) epitranscriptome [PDF]
Nucleic Acids Research, 2021 Abstract 5-Methylcytosine (m5C) is one of the most prevalent covalent modifications on RNA. It is known to regulate a broad variety of RNA functions, including nuclear export, RNA stability and translation. Here, we present m5C-Atlas, a database for comprehensive collection and annotation of RNA 5-methylcytosine.
Jiongming Ma +9 more
openaire +4 more sources
Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning
Frontiers in Plant Science, 2018 The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization
Jie Song +7 more
doaj +2 more sources
Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing [PDF]
International Journal of Genomics, 2018 Background. Compared with the well-studied 5-methylcytosine (m5C) in DNA, the role and topology of epitranscriptome m5C remain insufficiently characterized. Results.
Zhen Wei +11 more
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Detection, molecular function and mechanisms of m5C in cancer
Clinical and Translational MedicineInterest in RNA posttranscriptional modifications, particularly 5‐methylcytosine (m5C), has surged in recent years. Studies have shown that m5C plays a key role in cellular processes and is closely linked to tumourigenesis.
Linhui Zhang +6 more
doaj +3 more sources
Construction of a serum diagnostic signature based on m5C-related miRNAs for cancer detection [PDF]
Frontiers in Endocrinology, 2023 Currently, no clinically relevant non-invasive biomarkers are available for screening of multiple cancer types. In this study, we developed a serum diagnostic signature based on 5-methylcytosine (m5C)-related miRNAs (m5C-miRNAs) for multiple-cancer ...
Fuzhou Tang +7 more
doaj +2 more sources
Nature CommunicationsRNAs are often modified to invoke new activities. While many modifications are limited in frequency, restricted to non-coding RNAs, or present only in select organisms, 5-methylcytidine (m5C) is abundant across diverse RNAs and fitness-relevant across ...
Kristin A. Fluke +12 more
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Frontiers in Cell and Developmental Biology, 2022 Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive digestive malignancy due to frequent late-stage diagnosis, rapid progression and resistance to therapy.
Duo Yun +7 more
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Current Oncology, 2022 Recently, studies have revealed the prognostic value of 5-methylcytosine (m5C) in clear cell renal cell carcinoma (ccRCC). However, the role of m5C methylation in ccRCC immune infiltration and the immunotherapeutic response remains unknown.
Can Chen +3 more
doaj +2 more sources