Results 11 to 20 of about 11,326 (215)

Detection, molecular function and mechanisms of m5C in cancer

Clinical and Translational Medicine
Interest in RNA posttranscriptional modifications, particularly 5‐methylcytosine (m5C), has surged in recent years. Studies have shown that m5C plays a key role in cellular processes and is closely linked to tumourigenesis.
Linhui Zhang, Yuelong Li, Liqing Li, Fei Yao, Maoping Cai, Dingwei Ye, Yuanyuan Qu   +6 more
doaj   +3 more sources

m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets

Journal of Translational Medicine
5-Methylcytosine (m5C), an important RNA modification, has been extensively studied in colorectal cancer (CRC). In recent years, with advances in high-throughput sequencing technology and RNA modification detection tools, the role of m5C modification in ...
Jiawei Wang, Cenyi Qi, Ran Wang, Yuepeng Cao, Yuping Zhou, Guoliang Ye   +5 more
doaj   +3 more sources

Protocol for profiling RNA m5C methylation at base resolution using m5C-TAC-seq

STAR Protocols
Summary: RNA 5-methylcytosine (m5C) is a widespread modification and plays a crucial role in gene expression regulation. Here, we present a protocol for transcriptome-wide m5C methylome profiling at base resolution using bisulfite-free m5C detection ...
Xiaoting Zhang, Liang Lu, Chengqi Yi, Xiaoyu Li   +3 more
doaj   +3 more sources

The role of m5C methyltransferases in cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2023
The global leading cause of death is cardiovascular disease (CVD). Although advances in prevention and treatment have been made, the role of RNA epigenetics in CVD is not fully understood. Studies have found that RNA modifications regulate gene expression in mammalian cells, and m5C (5-methylcytosine) is a recently discovered RNA modification that ...
Yan-Yue Wang, Yuan Tian, Yong-Zhen Li, Yi-Fan Liu, Yu-Yan Zhao, Lin-Hui Chen, Chi Zhang   +6 more
openaire   +3 more sources

m5C Goes Viral [PDF]

Cell Host & Microbe, 2019
In this issue of Cell Host & Microbe, Courtney et al. (2019a) find that HIV-1 genomic RNA has much more m5C than cellular mRNA. Deleting the m5C "writer" NSUN2 decreases HIV-1 m5C levels, promotes translation of the HIV-1 5' gag gene, and alters splicing at the A2 site.
Shelby, Winans, Karen, Beemon
openaire   +2 more sources

A CNN based m5c RNA methylation predictor

Scientific Reports, 2023
AbstractPost-transcriptional modifications of RNA play a key role in performing a variety of biological processes, such as stability and immune tolerance, RNA splicing, protein translation and RNA degradation. One of these RNA modifications is m5c which participates in various cellular functions like RNA structural stability and translation efficiency,
Irum Aslam, Sajid Shah, Saima Jabeen, Mohammed ElAffendi, Asmaa A. Abdel Latif, Nuhman Ul Haq, Gauhar Ali   +6 more
openaire   +3 more sources

m5C-Atlas: a comprehensive database for decoding and annotating the 5-methylcytosine (m5C) epitranscriptome [PDF]

Nucleic Acids Research, 2021
Abstract 5-Methylcytosine (m5C) is one of the most prevalent covalent modifications on RNA. It is known to regulate a broad variety of RNA functions, including nuclear export, RNA stability and translation. Here, we present m5C-Atlas, a database for comprehensive collection and annotation of RNA 5-methylcytosine.
Jiongming Ma, Bowen Song, Zhen Wei, Daiyun Huang, Yuxin Zhang, Jionglong Su, João Pedro de Magalhães, Daniel J. Rigden, Jia Meng 0001, Kunqi Chen   +9 more
openaire   +2 more sources

Overall Survival Signature of 5-Methylcytosine Regulators Related Long Non-Coding RNA in Hepatocellular Carcinoma

Frontiers in Oncology, 2022
PurposeStudies reported that 5-methylcytosine (m5C) RNA transferase alters tumor progression; however, studies of m5C-related lncRNA remain lacking. This article intends to study the lncRNA modified by m5C RNA transferase in hepatocellular carcinoma ...
Qi Pan, Caiyu Yi, Yijie Zhang
doaj   +1 more source

RNA m5C methylation in cancer: mechanisms and biological impact. [PDF]

Oncogenesis
RNA modification, a prominent epigenetic mechanism, has been implicated in regulating RNA function, stability, processing, and interactions, including pseudouridylation, acetylation, and methylation. Recent evidence highlights that 5-methylcytosine (m5C) influences key cellular processes such as proliferation, differentiation, apoptosis, and stress ...
Guan Z, Li W, He Y, Guo W.
europepmc   +3 more sources

The Role of NSUN Family Genes in m5C Methylation and Diseases. [PDF]

Biomedicines
5-Methylcytosine (m5C) methylation is a widely present nucleic acid modification in various RNAs and is a reversible epigenetic modification that affects RNA stability, nuclear export, and translation processes. Methylation writers are responsible for adding methyl groups to RNA molecules, regulating gene expression and cellular function through ...
Jiang T, Jiang N, Chen X, Xiong Z.
europepmc   +4 more sources