Results 1 to 10 of about 2,478 (156)

NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization

Clinical and Translational Medicine
Background NOP2/Sun domain 2 (NSUN2) is one of the important RNA methyltransferases catalyzing 5‐methylcytosine (m5C) formation and participates in many critical bioprocesses.
Weiyao Li, Lekun Fang
exaly   +4 more sources

Aberrant KIF26B expression promotes bladder cancer progression through driving NSUN2 nuclear localization [PDF]

Journal of Hematology and Oncology
Abnormal expression of kinesins has been observed in several types of cancer. The present study provided the first evidence that KIF26B could induce RNA m5C modification in bladder cancer (BCa).
Xuan Shu, Xie Li-Ping
exaly   +3 more sources

Distinct Roles of m5C RNA Methyltransferase NSUN2 in Major Gynecologic Cancers [PDF]

Frontiers in Oncology, 2022
RNA methylation has recently emerged as an important category of epigenetic modifications, which plays diverse physiopathological roles in various cancers.
Lingfang Wang, Yasen Maimaitiyiming, Peng Wu   +2 more
exaly   +5 more sources

RNA methyltransferase NSUN2 promotes growth of hepatocellular carcinoma cells by regulating fizzy‐related‐1 in vitro and in vivo

Kaohsiung Journal of Medical Sciences, 2021
The aim of the study was to investigate the role of NSUN2 (NOP2/Sun RNA Methyltransferase Family Member 2) in hepatocellular carcinoma (HCC). The expressions of NSUN2 and FZR1 were measured. Cell viability, proliferation, and apoptosis were assessed. HCC
Long-Jiang Shao
exaly   +2 more sources

ETV4 Improves Cerebral Ischemia-Reperfusion Injury by Restraining YBX1-GPX4-Ferroptosis Cascades. [PDF]

Brain Behav
ABSTRACT Background Cerebral ischemia‐reperfusion injury (CIRI) is a critical pathological process following ischemic stroke, with ferroptosis being increasingly recognized as a key contributor to neuronal damage. However, the regulatory mechanisms, particularly the role of specific transcription factors like E26 transformation‐specific variant 4 (ETV4)
Xu Q, Deng F, Yu D.
europepmc   +2 more sources

GPRC5B Identified by m5C meRIP-Seq Suppresses Apoptosis in Osteosarcoma Through NSUN2-Mediated RNA Methylation. [PDF]

Cancer Sci
We performed the first transcriptome‐wide profiling of m5C modifications in osteosarcoma, analyzing four pairs of tumor and adjacent normal tissues. We revealed that NSUN2 suppresses apoptosis in osteosarcoma cells by promoting GPRC5B m5C modification and expression.
Chen Z, Yang M, Liang X, Yang Z, Mai W, Wang Y, Lu Y, Wang R, Han Y, Xie Y, Cai L.   +10 more
europepmc   +2 more sources

Tumor cell-intrinsic NSUN2 deficiency reprograms macrophages to sensitize non-small cell lung cancer to EGFR inhibitors by reversing immune evasion [PDF]

Neoplasia: An International Journal for Oncology Research
Despite EGFR-tyrosine kinase inhibitors (EGFR-TKI) have improved outcomes in non-small cell lung cancer (NSCLC), acquired resistance remains a challenge.
Yueqin Wang, Jingyao Wei, Wenbin Xu, Yu Zhang, Luyao Feng, Lizhen Zhang, Shuaibing Liu, Xin Tian   +7 more
doaj   +2 more sources

NSUN2 mediated-aberrant 5-methylcytosine methylation regulates autophagy-related ferroptosis in oral squamous cell carcinoma progression [PDF]

Cell Death and Disease
Oral squamous cell carcinoma (OSCC) is a common malignant tumor with high metastasis rates and poor prognosis. This study investigated the role of NOP2/Sun RNA methyltransferase family member 2 (NSUN2), a key 5-methylcytosine (m5C) methyltransferase, and
Yunyang Lu, Runze Li, Weidong Du, Jie Wu, Yi He, Lingyu Yuan, Xun Chen, Shiyu Lv, Fangyang Shi, Jiajun Hu, Wei Zhao, Dongsheng Yu   +11 more
doaj   +2 more sources

NSUN2 promotes leukemogenesis by ferritin heavy chain 1-mediated anti-ferroptosis and enhancing global protein synthesis in an m5C-dependent manner in B-acute lymphoblastic leukemia [PDF]

Clinical Epigenetics
Background NOP2/Sun RNA methyltransferase family member 2 (NSUN2) catalyzes 5-methylcytosine (m5C) modifications in tRNA, rRNA, and mRNA, playing critical roles in various malignancies.
Yigang Yuan, Min Li, Xuanyu Yu, Chen Meng, Shirui Yu, Xinyao Chen, Shixin Zhang, Liuzhi Shi, Xiaoyi Qin, Ziyang Huang, Chongyun Xing, Shanhu Qian, Bin Zhou, Shenmeng Gao   +13 more
doaj   +2 more sources

Targeting the NSUN2–DHODH axis reverses ferroptosis resistance and oxaliplatin resistance in colorectal cancer [PDF]

Frontiers in Pharmacology
BackgroundOxaliplatin (OXA) is a standard chemotherapy for advanced colorectal cancer (CRC), yet acquired resistance frequently limits its efficacy.
Junyi Zhang, Junxiao Shen, Tangye Zeng, Chang Gao, Biao Sheng, Junliang Li, Weiqi Zeng, Jieyi Shen, Chong Shen, Jiaojiao Wang, Jiaojiao Wang, Jiaojiao Wang, Jianwei Wang, Jianwei Wang   +13 more
doaj   +2 more sources