Results 1 to 10 of about 2,610 (103)

NSUN2 Promotes Cancer Immune Evasion via Its Moonlighting Function Acting on Metabolic Reprogramming [PDF]

Cancer Communications
Background: Although cancer immunotherapies have revolutionized cancer treatment, a substantial proportion of patients remain unresponsive. Elucidating the molecular mechanisms underlying tumor immune evasion and identifying key regulators are essential ...
Baoxiang Chen, Yanrong Deng, Xiang Zhai, Peiyun Wang, Kunming Lei, Siyuan Yin, Quanjiao Chen, Qun Qian, Jinfang Zhang, Xianghai Ren, Jianhong Zhao, Congqing Jiang   +11 more
doaj   +2 more sources

RNA methyltransferase NSUN2 promotes growth of hepatocellular carcinoma cells by regulating fizzy-related-1 in vitro and in vivo

Kaohsiung Journal of Medical Sciences, 2021
The aim of the study was to investigate the role of NSUN2 (NOP2/Sun RNA Methyltransferase Family Member 2) in hepatocellular carcinoma (HCC). The expressions of NSUN2 and FZR1 were measured. Cell viability, proliferation, and apoptosis were assessed. HCC
Longjiang Shao
exaly   +2 more sources

Tumor-intrinsic NSUN2 orchestrates immunosuppression in lung adenocarcinoma via the m5C-HDAC8-CCL5 axis [PDF]

Experimental Hematology & Oncology
Background Insufficient T-cell infiltration is a major barrier to the efficacy of immune checkpoint inhibitors (ICIs) in lung adenocarcinoma (LUAD). We aimed to investigate how the tumor-intrinsic m5C methyltransferase NSUN2 shapes the immune landscape ...
Wangyang Meng, Tong Lu, Mingyuan Du, Xin Dai, Yichao Han, Yingyi Li, Haimin Xu, Biaolong Yang, Zeyu Wang, Hailei Du, Keman Liao, Xinnan Liu, Yidan Sun, Cui Yang, Dong Dong, Yan Yan, Wei Guo, Bin Li, Hecheng Li   +18 more
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Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis [PDF]

Advanced Science
Osteoarthritis (OA) is a prevalent age‐related disease associated with significant pain and disability. Although 5‐methylcytosine (m5C) modification is implicated in age‐related diseases, its role in OA remains unclear.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
doaj   +2 more sources

NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization

Clinical and Translational Medicine
Background NOP2/Sun domain 2 (NSUN2) is one of the important RNA methyltransferases catalyzing 5‐methylcytosine (m5C) formation and participates in many critical bioprocesses.
Lekun Fang, Weiyao Li, Wang Wencong
exaly   +2 more sources

NSUN2-FOSB reciprocity facilitates leukemogenesis in an m5C-dependent manner by increasing BCL2L1 expression [PDF]

Haematologica
NOP2/Sun RNA methyltransferase family member 2 (NSUN2) catalyzes 5-methylcytosine (m5C) modifications on RNA to regulate mRNA stability. However, its roles in normal hematopoiesis and leukemogenesis remain poorly understood.
Bin Zhou, Yigang Yuan, Yue Cai, Jingying Zhou, Liuzhi Shi, Yaqian Qin, Chen Meng, Shixin Zhang, Shirui Yu, Xinyao Chen, Xiaofei He, Shanshan Wu, Min Li, Xuanyu Yu, Yifen Shi, Chongyun Xing, Chiqi Chen, Meng Zhao, Shenmeng Gao   +18 more
doaj   +2 more sources

NSUN2 suppresses ferroptosis via the KLF4/GPX4 axis to preserve stem cells and tissues [PDF]

Redox Biology
RNA 5-methylcytosine (m5C) methylation has emerged as an important epitranscriptomic regulator of gene expression, yet its role in stem cell maintenance remains not well understood.
Ying Zhan, Boxiong Deng, Xiaoling Zeng, Ying Guo, Min Xie, Chonghui Tang, Ying Li, Yi Tian, Lijuan Huang, Ziqing Yang, Yi Liu, Jianing Zhang, Shasha Wang, Haiqing Kuang, Aijun Deng, Xuran Dong, Chun Zhang, Hong Ouyang, Lekun Fang, Weisi Lu, Xuri Li   +20 more
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Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis [PDF]

Advanced Science
Rheumatoid arthritis (RA) involves persistent synovial inflammation and progressive destruction of cartilage and bone, where aberrantly activated fibroblast‐like synoviocytes (FLSs) play a central role.
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
doaj   +2 more sources

NSUN2/m5C/TPI1 axis promotes glycolysis and immune evasion in breast cancer [PDF]

Journal of Translational Medicine
Background Aerobic glycolysis and immune evasion drive tumor development. 5-methylcytosine (m5C) methyltransferase NSUN2 acts as an oncogene in breast cancer (BC), but the molecular mechanisms remain incompletely elucidated.
Xinming Song, Qihang Li, Ziteng Xiao, Haiqing Luo, Xiangyong Li   +4 more
doaj   +2 more sources

NSUN2 regulates PARP9 progression through m5C modification to mediate breast cancer progression [PDF]

Cell Division
Background m5C modification plays a vital role in the progression of human cancers, including breast cancer (BC), but the function of NOP2/Sun RNA methyltransferase 2 (NSUN2), an RNA m5C modification enzyme, remains largely unclear.
Xin Li, Changjiao Yan, Jun Yi, Jun Yun, Fengqiang Cui, Xiaolong Xu, Yike Li, Xin Xu   +7 more
doaj   +2 more sources