NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization
Clinical and Translational MedicineBackground NOP2/Sun domain 2 (NSUN2) is one of the important RNA methyltransferases catalyzing 5‐methylcytosine (m5C) formation and participates in many critical bioprocesses.
WEIYAO LI
exaly +4 more sources
Positive epigenetic regulation loop between AR and NSUN2 promotes prostate cancer progression
Clinical and Translational Medicine, 2022 Background Prostate cancer (PCa) is a major type of cancer in man worldwide. Androgen deprivation therapy (ADT) and the next‐generation androgen receptor (AR) pathway inhibitors have acquired great success in treating PCa.
wenkai zhu, Fangning Wan, Wen-Hao Xu
exaly +4 more sources
Molecular Cancer, 2023 Background RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear.
yueqin wang, Jingyao Wei, luyao Feng
exaly +2 more sources
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation
Cell Death and Disease, 2021 The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the regulation of cell proliferation and metastasis formation and is upregulated in multiple cancers.
Yuanbo Hu, Xian Shen, Xiang-yang Xue
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RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation [PDF]
Acta Neuropathologica, 2022 Epitranscriptomic regulation adds a layer of post-transcriptional control to brain function during development and adulthood. The identification of RNA-modifying enzymes has opened the possibility of investigating the role epitranscriptomic changes ...
Tohid Siddiqui +2 more
exaly +3 more sources
Targeting the NSUN2-DHODH axis reverses ferroptosis resistance and oxaliplatin resistance in colorectal cancer. [PDF]
Front PharmacolBackgroundOxaliplatin (OXA) is a standard chemotherapy for advanced colorectal cancer (CRC), yet acquired resistance frequently limits its efficacy.
Zhang J +10 more
europepmc +2 more sources
NSUN2 promotes leukemogenesis by ferritin heavy chain 1-mediated anti-ferroptosis and enhancing global protein synthesis in an m5C-dependent manner in B-acute lymphoblastic leukemia. [PDF]
Clin EpigeneticsBackground NOP2/Sun RNA methyltransferase family member 2 (NSUN2) catalyzes 5-methylcytosine (m5C) modifications in tRNA, rRNA, and mRNA, playing critical roles in various malignancies.
Yuan Y +13 more
europepmc +2 more sources
Aberrant KIF26B expression promotes bladder cancer progression through driving NSUN2 nuclear localization. [PDF]
J Hematol OncolAbnormal expression of kinesins has been observed in several types of cancer. The present study provided the first evidence that KIF26B could induce RNA m5C modification in bladder cancer (BCa).
Wang JM +6 more
europepmc +2 more sources
NSUN2 mediated-aberrant 5-methylcytosine methylation regulates autophagy-related ferroptosis in oral squamous cell carcinoma progression. [PDF]
Cell Death DisOral squamous cell carcinoma (OSCC) is a common malignant tumor with high metastasis rates and poor prognosis. This study investigated the role of NOP2/Sun RNA methyltransferase family member 2 (NSUN2), a key 5-methylcytosine (m5C) methyltransferase, and
Lu Y +11 more
europepmc +2 more sources
NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation [PDF]
Journal of Cellular Biochemistry, 2017 N6‐methyladenosine (m6A) and m5C methylation are two major types of RNA methylation, but the impact of joint modifications on the same mRNA is unknown.
Bin Jiang, Yali Dou, Myriam Gorospe
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