Results 1 to 10 of about 2,411 (105)

RNA methyltransferase NSUN2 promotes growth of hepatocellular carcinoma cells by regulating fizzy‐related‐1 in vitro and in vivo

Kaohsiung Journal of Medical Sciences, 2021
The aim of the study was to investigate the role of NSUN2 (NOP2/Sun RNA Methyltransferase Family Member 2) in hepatocellular carcinoma (HCC). The expressions of NSUN2 and FZR1 were measured. Cell viability, proliferation, and apoptosis were assessed. HCC
Longjiang Shao
exaly   +2 more sources

NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization

Clinical and Translational Medicine
Background NOP2/Sun domain 2 (NSUN2) is one of the important RNA methyltransferases catalyzing 5‐methylcytosine (m5C) formation and participates in many critical bioprocesses.
Lekun Fang, Weiyao Li
exaly   +2 more sources

Tumor cell-intrinsic NSUN2 deficiency reprograms macrophages to sensitize non-small cell lung cancer to EGFR inhibitors by reversing immune evasion. [PDF]

Neoplasia
Despite EGFR-tyrosine kinase inhibitors (EGFR-TKI) have improved outcomes in non-small cell lung cancer (NSCLC), acquired resistance remains a challenge.
Wang Y, Wei J, Xu W, Zhang Y, Feng L, Zhang L, Liu S, Tian X.   +7 more
europepmc   +2 more sources

Targeting the NSUN2-DHODH axis reverses ferroptosis resistance and oxaliplatin resistance in colorectal cancer. [PDF]

Front Pharmacol
BackgroundOxaliplatin (OXA) is a standard chemotherapy for advanced colorectal cancer (CRC), yet acquired resistance frequently limits its efficacy.
Zhang J, Shen J, Zeng T, Gao C, Sheng B, Li J, Zeng W, Shen J, Shen C, Wang J, Wang J.   +10 more
europepmc   +2 more sources

NSUN2 promotes leukemogenesis by ferritin heavy chain 1-mediated anti-ferroptosis and enhancing global protein synthesis in an m⁵C-dependent manner in B-acute lymphoblastic leukemia. [PDF]

Clin Epigenetics
Background NOP2/Sun RNA methyltransferase family member 2 (NSUN2) catalyzes 5-methylcytosine (m5C) modifications in tRNA, rRNA, and mRNA, playing critical roles in various malignancies.
Yuan Y, Li M, Yu X, Meng C, Yu S, Chen X, Zhang S, Shi L, Qin X, Huang Z, Xing C, Qian S, Zhou B, Gao S.   +13 more
europepmc   +2 more sources

NSUN2 mediated-aberrant 5-methylcytosine methylation regulates autophagy-related ferroptosis in oral squamous cell carcinoma progression. [PDF]

Cell Death Dis
Oral squamous cell carcinoma (OSCC) is a common malignant tumor with high metastasis rates and poor prognosis. This study investigated the role of NOP2/Sun RNA methyltransferase family member 2 (NSUN2), a key 5-methylcytosine (m5C) methyltransferase, and
Lu Y, Li R, Du W, Wu J, He Y, Yuan L, Chen X, Lv S, Shi F, Hu J, Zhao W, Yu D.   +11 more
europepmc   +2 more sources

Aberrant KIF26B expression promotes bladder cancer progression through driving NSUN2 nuclear localization. [PDF]

J Hematol Oncol
Abnormal expression of kinesins has been observed in several types of cancer. The present study provided the first evidence that KIF26B could induce RNA m5C modification in bladder cancer (BCa).
Wang JM, Xie HY, Zhang FH, Shu X, Luo JD, Xie LP, Li JF.   +6 more
europepmc   +2 more sources

NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis

Redox Biology
Lactate-mediated lactylation on target proteins is recently identified as the novel posttranslational modification with profound biological functions.
Yongliang Zhao, Zixiang Chen
exaly   +3 more sources

NSUN2 restrains gastric cancer cell apoptosis and ferroptosis by promoting the m5C modification of EPYC. [PDF]

Hereditas
Background Epiphycan (EPYC) has been confirmed to play an oncogenic role in many cancers. However, its role and mechanism in gastric cancer (GC) progression has not been explored.
Wu L, Chen B, Cheng S, Fang X, Zhou F.
europepmc   +2 more sources

RNA methyltransferase NSUN2-mediated m5C methylation promotes Cr(VI)-induced malignant transformation and lung cancer by accelerating metabolism reprogramming

Environment International
Hexavalent chromium [Cr(VI)], one common environmental contaminant, has long been recognized as a carcinogen associated with lung cancer, but roles and mechanisms of Cr(VI)-induced epigenetic dysregulations in carcinogenesis remain to be investigated. In
Bing-Hua Jiang, Yun-Xia Xie
exaly   +3 more sources