Results 31 to 40 of about 2,478 (156)

Mutations in NSUN2 Cause Autosomal- Recessive Intellectual Disability [PDF]

The American Journal of Human Genetics, 2012
With a prevalence between 1 and 3%, hereditary forms of intellectual disability (ID) are among the most important problems in health care. Particularly, autosomal-recessive forms of the disorder have a very heterogeneous molecular basis, and genes with an increased number of disease-causing mutations are not common.
Abbasi-Moheb, Lia, Mertel, Sara, Gonsior, Melanie, Nouri-Vahid, Leyla, Kahrizi, Kimia, Cirak, Sebahattin, Wieczorek, Dagmar, Motazacker, M. Mahdi, Esmaeeli-Nieh, Sahar, Cremer, Kirsten, Weißmann, Robert, Tzschach, Andreas, Garshasbi, Masoud, Abedini, Seyedeh S., Najmabadi, Hossein, Ropers, H. Hilger, Sigrist, Stephan J., Kuss, Andreas W.   +17 more
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The Effect of Methyltransferase NSUN2 in Stroke

, 2021
Abstract Stroke is one of the most important diseases that seriously threaten the health and public health of elderly patients.NSUN2 refers to the predominant methyltransferase for RNA m5C methylation, contributing to increased RNA stability, translocation and translation, and playing an important role in the physiopathology.
Xuqing Ni, Xia Liu, Xinyu Yao, Shan Li, Yurun Zhu, Ye Zhu, Yunchang Mo, Qinxue Dai, Junlu Wang   +8 more
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NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer

Cell Death Discovery, 2023
NSUN2 is a nuclear RNA methyltransferase which catalyzes 5-methylcytosine (m5C), a posttranscriptional RNA modification. Aberrant m5C modification has been implicated in the development of multiple malignancies. However, its function in pancreatic cancer
Guizhen Zhang, Liwen Liu, Jianhao Li, Yu Chen, Yun Wang, Yize Zhang, Zihui Dong, Wenhua Xue, Ranran Sun, Guangying Cui   +9 more
doaj   +1 more source

Methylation by NSun2 Represses the Levels and Function of MicroRNA 125b [PDF]

Molecular and Cellular Biology, 2014
Methylation is a prevalent posttranscriptional modification of RNAs. However, whether mammalian microRNAs are methylated is unknown. Here, we show that the tRNA methyltransferase NSun2 methylates primary (pri-miR-125b), precursor (pre-miR-125b), and mature microRNA 125b (miR-125b) in vitro and in vivo.
Shuai, Yuan, Hao, Tang, Junyue, Xing, Xiuqin, Fan, Xiaoyu, Cai, Qiu, Li, Pei, Han, Yuhong, Luo, Zhuojun, Zhang, Bin, Jiang, Yali, Dou, Myriam, Gorospe, Wengong, Wang   +12 more
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NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation

Cell Death and Disease, 2021
The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the regulation of cell proliferation and metastasis formation and is upregulated in multiple cancers.
Yuanbo Hu, Chenbin Chen, Xinya Tong, Sian Chen, Xianjing Hu, Bujian Pan, Xiangwei Sun, Zhiyuan Chen, Xinyu Shi, Yingying Hu, Xian Shen, Xiangyang Xue, Mingdong Lu   +12 more
doaj   +1 more source

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Cell Death Discovery, 2023
Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury.
Yi Wang, Yuxin Zan, Yingying Huang, Xiaoyun Peng, Shinan Ma, Ji Ren, Xiao Li, Lin Wei, Xiaoli Wang, Yahong Yuan, Junming Tang, Zhongqun Zhan, Zhixiao Wang, Yan Ding   +13 more
doaj   +1 more source

NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m5C methylation

Cell Death and Disease, 2023
5-methylcytosine (m5C) modification, which is mainly induced by the RNA methyltransferase NSUN2 (NOP2/Sun domain family, member 2), is an important chemical posttranscriptional modification in mRNA and has been proven to play important roles in the ...
Min Yang, Renxiong Wei, Sheng Zhang, Sang Hu, Xiaoxiao Liang, Zhiqiang Yang, Chong Zhang, Yufeng Zhang, Lin Cai, Yuanlong Xie   +9 more
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Impaired hippocampal NMDAR-LTP in a transgenic model of NSUN2-deficiency

Neurobiology of Disease, 2022
Biallelic loss-of-function NSUN2 mutations have recently been associated with cases of Autism Spectrum Condition (ASC), and NSun2-deficiency was also previously shown to cause a severe autosomal recessive intellectually disability disorder syndrome in which patients can sometimes display autistic behaviour.
George, Harry, Bashir, Zafar I., Hussain, Shobbir   +2 more
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NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

Nucleic Acids Research, 2019
Abstract Expression of human mitochondrial DNA is indispensable for proper function of the oxidative phosphorylation machinery. The mitochondrial genome encodes 22 tRNAs, 2 rRNAs and 11 mRNAs and their post-transcriptional modification constitutes one of the key regulatory steps during mitochondrial gene expression.
Van Haute, Lindsey, Lee, Song-Yi, McCann, Beverly J, Powell, Christopher A, Bansal, Dhiru, Vasiliauskaitė, Lina, Garone, Caterina, Shin, Sanghee, Kim, Jong-Seo, Frye, Michaela, Gleeson, Joseph G, Miska, Eric A, Rhee, Hyun-Woo, Minczuk, Michal   +13 more
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NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections

Emerging Microbes and Infections, 2023
5-Methylcytosine (m5C) is a widespread post-transcriptional RNA modification and is reported to be involved in manifold cellular responses and biological processes through regulating RNA metabolism.
Hongyun Wang, Jiangpeng Feng, Cong Zeng, Jiejie Liu, Zhiying Fu, Dehe Wang, Yafen Wang, Lu Zhang, Jiali Li, Ao Jiang, Miao He, Yuanyuan Cao, Kun Yan, Hao Tang, Deyin Guo, Ke Xu, Xiang Zhou, Li Zhou, Ke Lan, Yu Zhou, Yu Chen   +20 more
doaj   +1 more source