Results 31 to 40 of about 2,920 (152)

NSUN2-mediated RNA m⁵C modification modulates uveal melanoma cell proliferation and migration

, 2022
RNA 5-methylcytosine (m5C) is a widespread post-transcriptional modification involved in diverse biological processes through controlling RNA metabolism. However, its roles in uveal melanoma (UM) remain unknown. Here, we describe the biological roles and
Xiaoyan Chen (146508), Dan-Ning Hu (146536), Weiwei Xu (1894642), Guangying Luo (12027180), Peter S. Reinach (9194252), Dongsheng Yan (146499), Siqi Wang (420799), Jiao Wang (47178), Feng Dong (142012)   +8 more
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NSUN2-mediated m⁵C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections

, 2023
5-Methylcytosine (m5C) is a widespread post-transcriptional RNA modification and is reported to be involved in manifold cellular responses and biological processes through regulating RNA metabolism.
Cong Zeng (145162), Miao He (148269), Yuanyuan Cao (701070), Jiangpeng Feng (9287738), Dehe Wang (2969067), Ke Xu (134879), Li Zhou (54356), Jiali Li (436886), Yu Chen (29959), Hongyun Wang (225359), Deyin Guo (201757), Ao Jiang (3971312), Zhiying Fu (14652128), Jiejie Liu (388856), Kun Yan (300887), Lu Zhang (50563), Yafen Wang (2021947), Ke Lan (232754), Hao Tang (44155), Xiang Zhou (164107), Yu Zhou (89766)   +20 more
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NSUN2-mediated m⁵C in HBV RNA contributes to HBV RNA stability.

, 2023
(A) Schematic diagram of site C2017 and C131 mutations on pCMV-pgRNA. Red arrows indicate positions of these three sites. (B) Northern blot result (left) and gray degree analysis (right) of HBV pgRNA after transfection with pCMV-pgRNA and its mutants ...
Xianying Chen (11248785), Cong Zeng (145162), Miao He (148269), Jiangpeng Feng (9287738), Tianmo Xu (11029548), Chengbao Ma (17549768), Shimin Yang (440641), Peipei Yao (17549765), Li Zhou (54356), Jiali Li (436886), Yu Chen (29959), Hongyun Wang (225359), Jiejie Liu (388856), Kun Yan (300887), Yuchen Xia (9287840), Zaichao Xu (15877593), Huan Yan (445452)   +16 more
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NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation

Cell Death and Disease, 2021
The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the regulation of cell proliferation and metastasis formation and is upregulated in multiple cancers.
Yuanbo Hu, Chenbin Chen, Xinya Tong, Sian Chen, Xianjing Hu, Bujian Pan, Xiangwei Sun, Zhiyuan Chen, Xinyu Shi, Yingying Hu, Xian Shen, Xiangyang Xue, Mingdong Lu   +12 more
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Single-cell analysis of NSUN2.

, 2023
(A) Expression of NSUN2 in malignant cells, stromal cells, immune cells and functional cells. (B) Scatter plot describing the expression level of NSUN2 in the GSE108989 dataset.
Wei Xiong (58411), Mengna Li (4987769), Hongyu Deng (104622), Ming Zhou (73279), Faqing Tang (326220), Changning Xue (17061040), Lemei Zheng (17061034), Yumei Duan (7040045), Kelin She (11412944), Jianxia Wei (17061037), Shipeng Chen (693094), Guiyuan Li (129719)   +11 more
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Expression of NSUN2 in different tumor types.

, 2023
(A) The mRNA expression of NSUN2 in some tumor types and normal tissues. T, tumor; N, normal. (B) NSUN2 protein expression in BRCA, HNSC, LUAD, LIHC, colon cancer, UCEC, pancreatic adenocarcinoma and ovarian cancer (OV).
Wei Xiong (58411), Mengna Li (4987769), Hongyu Deng (104622), Ming Zhou (73279), Faqing Tang (326220), Changning Xue (17061040), Lemei Zheng (17061034), Yumei Duan (7040045), Kelin She (11412944), Jianxia Wei (17061037), Shipeng Chen (693094), Guiyuan Li (129719)   +11 more
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Expression of NSUN2 in tumor types.

, 2023
(A) Analysis of mRNA expression of NSUN2 in different cancer types by TIMER database. (B) Protein expression of NSUN2 in glioblastoma multiformine. (C) Protein expression of NSUN2 in clear cell RCC (*PPP (TIF)
Wei Xiong (58411), Mengna Li (4987769), Hongyu Deng (104622), Ming Zhou (73279), Faqing Tang (326220), Changning Xue (17061040), Lemei Zheng (17061034), Yumei Duan (7040045), Kelin She (11412944), Jianxia Wei (17061037), Shipeng Chen (693094), Guiyuan Li (129719)   +11 more
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The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]

, 2009
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Michaela Frye, Benavente, Sandra Blanco, Elisabete Nascimento, Kurowski, Agata, Nascimento, Elisabete, Hussain, Shobbir, Ilaria Dragoni, Dragoni, Ilaria, Gillich, Astrid, Shobbir Hussain, Sandra Blanco Benavente, Astrid Gillich, Frye, Michaela, Peter Humphreys, Humphreys, Peter, Agata Kurowski   +15 more
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Enrichment analysis of NSUN2-related proteins and genes.

, 2023
(A) The proteins most closely related to NSUN2. (B-F) Analysis of NSUN2-related genes, including CCT5, DNAJC21, BRIX1, PAPD7 and NUP155. (G) The heatmap describes the expression of five NSUN2-correlated genes in different cancer types and the ...
Wei Xiong (58411), Mengna Li (4987769), Hongyu Deng (104622), Ming Zhou (73279), Faqing Tang (326220), Changning Xue (17061040), Lemei Zheng (17061034), Yumei Duan (7040045), Kelin She (11412944), Jianxia Wei (17061037), Shipeng Chen (693094), Guiyuan Li (129719)   +11 more
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NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m5C methylation

Cell Death and Disease, 2023
5-methylcytosine (m5C) modification, which is mainly induced by the RNA methyltransferase NSUN2 (NOP2/Sun domain family, member 2), is an important chemical posttranscriptional modification in mRNA and has been proven to play important roles in the ...
Min Yang, Renxiong Wei, Sheng Zhang, Sang Hu, Xiaoxiao Liang, Zhiqiang Yang, Chong Zhang, Yufeng Zhang, Lin Cai, Yuanlong Xie   +9 more
doaj   +1 more source