Results 31 to 40 of about 2,411 (105)

NSUN2‐mediated m5C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression

Clinical and Translational Medicine, 2023
Background The precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism, and is necessary for the maintenance of epigenome homeostasis.
Sipeng Zuo, Lin Li, Xuyang Wen, Xiang Gu, Ai Zhuang, Rui Li, Fuxiang Ye, Shengfang Ge, Xianqun Fan, Jiayan Fan, Peiwei Chai, Linna Lu   +11 more
doaj   +1 more source

NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury

Biology Direct
Background Doxorubicin (Dox) is associated with various liver injuries, limiting its clinical utility. This study investigates whether NSUN2 participates in Dox-induced liver injury and the associated molecular mechanism.
Yingying Huang, Xiao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan, Xiju He, Yijun Tang, Yan Ding   +8 more
doaj   +1 more source

NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming

Cancer & Metabolism
Purpose Cancer cells rely on serine biosynthesis for growth, but its regulation in colorectal cancer (CRC) remains not well understood. This study identifies the m5C methyltransferase NSUN2 (NOP2/Sun domain family, member 2) as a key regulator of serine ...
Hao Li, Tingyue Gong, Yongheng Zhao, Yang Luo, Shuibin Tang, Tingfeng Wang, Haiping Lin, Ming Zhong   +7 more
doaj   +1 more source

Unveiling the potential impact of RNA m5C methyltransferases NSUN2 and NSUN6 on cellular aging

Frontiers in Genetics
NSUN2 and NSUN6, two family members of NOL1/NSUN protein, are mainly responsible for catalyzing the formation of 5-methylcytosine (m5C) in RNA and highly involved in the physiological and pathological processes of many diseases.
Jiale Zhou, Jiale Zhou, Yang Han, Fuxi Ji, Renquan Zhang, Yuru Liang, Xudong Zhao, Ruizhe Hou   +7 more
doaj   +1 more source

NSUN2–tRNAVal−CAC-axis-regulated codon-biased translation drives triple-negative breast cancer glycolysis and progression

Cellular & Molecular Biology Letters
Background Epitranscriptomic data indicate that aberrant tRNA modifications in malignant diseases can promote tumor growth by facilitating oncogene translation.
Wenlong Wang, Ying Ding, Haixi Zhao, Shouman Wang, Juan Huang, Lunquan Sun   +5 more
doaj   +1 more source

NSUN2-mediated RNA m5C modification modulates uveal melanoma cell proliferation and migration

Epigenetics, 2022
RNA 5-methylcytosine (m5C) is a widespread post-transcriptional modification involved in diverse biological processes through controlling RNA metabolism. However, its roles in uveal melanoma (UM) remain unknown. Here, we describe the biological roles and
Guangying Luo, Weiwei Xu, Xiaoyan Chen, Siqi Wang, Jiao Wang, Feng Dong, Dan-Ning Hu, Peter S. Reinach, Dongsheng Yan   +8 more
doaj   +1 more source

RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer

Experimental and Molecular Medicine
5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional ...
Xiaoyi Liu, Qinglv Wei, Chenyue Yang, Hongyan Zhao, Jie Xu, Youchaou Mobet, Qingya Luo, Dan Yang, Xinzhao Zuo, Ningxuan Chen, Yu Yang, Li Li, Wei Wang, Jianhua Yu, Jing Xu, Tao Liu, Ping Yi   +16 more
doaj   +1 more source

NSUN2 Promotes Cardiac Hypertrophy by Activating LARP1–GATA4 Axis

Engineering
Pathological cardiac hypertrophy contributes to the development of heart failure (HF). NOL1/NOP2/Sun domain family member 2 (NSUN2) is implicated in pathophysiological processes of many diseases.
Yingqi Liu, Fan Wu, Kuiwu Liu, Shuting Yu, Changhao Wang, Xin Li, Zhiyong Sun, Wanhong Li, Yi Zhang, Tiantian Ju, Qian Liu, Min Huang, Zhongting Mei, Zhezhe Qu, Meixi Lu, Xiaochen Pang, Yingqiong Jia, Jianhao Jiang, Shunkang Dou, Na Li, Yaozhi Zhang, Ying Li, Chuanhao Huang, Yuechao Dong, Baofeng Yang, Weijie Du   +25 more
doaj   +1 more source

NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA

Scientific Reports
RNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers.
Yang Jiang, Jing Sun, Yuyan Chen, Lin Cheng, Saran Feng, Yan Wang, Congcong Sun   +6 more
doaj   +1 more source

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis

Cell Death and Disease
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers.
Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu   +9 more
doaj   +1 more source