Results 31 to 40 of about 3,656 (193)

NSUN2-mediated RNA m⁵C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA. [PDF]

Sci Rep
RNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers.
Jiang Y, Sun J, Chen Y, Cheng L, Feng S, Wang Y, Sun C.   +6 more
europepmc   +2 more sources

Metabolic Recoding of NSUN2‐Mediated m5C Modification Promotes the Progression of Colorectal Cancer via the NSUN2/YBX1/m5C‐ENO1 Positive Feedback Loop

Advanced Science
The RNA modification, 5‐methylcytosine (m5C), has recently gained prominence as a pivotal post‐transcriptional regulator of gene expression, intricately intertwined with various tumorigenic processes.
Baoxiang Chen, Yanrong Deng, Yuntian Hong, Lifang Fan, Xiang Zhai, Heng Hu, Siyuan Yin, Quanjiao Chen, Xiaoyu Xie, Xianghai Ren, Jianhong Zhao, Congqing Jiang   +11 more
doaj   +3 more sources

NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m5C methylation

Journal of Translational Medicine
Background Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and retinal traction, thereby ...
Runze Wang, Wei Xue, Feifei Kan, Huiying Zhang, Di Wang, Lei Wang, Jianwen Wang   +6 more
doaj   +3 more sources

A novel variant in NSUN2 causes intellectual disability in a Chinese family

BMC Medical Genomics, 2023
NSUN2-intellectual disability syndrome, also known as intellectual disability type 5 (MRT5), is an autosomal recessive disorder that is characterized by intellectual disability (ID), postnatal growth retardation, dysmorphic facies, microcephaly, short ...
Qi Yang, Qiang Zhang, Zailong Qin, Shang Yi, Jingsi Luo   +4 more
doaj   +3 more sources

RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence [PDF]

Oncotarget, 2016
The tRNA methyltransferase NSUN2 delays replicative senescence by regulating the translation of CDK1 and CDKN1B mRNAs. However, whether NSUN2 influences premature cellular senescence remains untested. Here we show that NSUN2 methylates SHC mRNA in vitro and in cells, thereby enhancing the translation of the three SHC proteins, p66SHC, p52SHC, and ...
Cai, Xiaoyu, Hu, Yuanyuan, Tang, Hao, Hu, Han, Pang, Lijun, Xing, Junyue, Liu, Zhenyun, Luo, Yuhong, Jiang, Bin, Liu, Te, Gorospe, Myriam, Chen, Chuan, Wang, Wengong   +12 more
openaire   +5 more sources

NOP2/Sun RNA methyltransferase 2 is a potential pan-cancer prognostic biomarker and is related to immunity.

PLoS ONE, 2023
BackgroundNOP2/Sun RNA methyltransferase 2 (NSUN2), an important methyltransferase of m5C, has been poorly studied in cancers, and the relationship between NSUN2 and immunity remains largely unclear.
Lemei Zheng, Mengna Li, Jianxia Wei, Shipeng Chen, Changning Xue, Yumei Duan, Faqing Tang, Guiyuan Li, Wei Xiong, Kelin She, Hongyu Deng, Ming Zhou   +11 more
doaj   +1 more source

Reorganization of the Landscape of Translated mRNAs in NSUN2-Deficient Cells and Specific Features of NSUN2 Target mRNAs

International Journal of Molecular Sciences, 2022
The RNA cytosine C5 methyltransferase NSUN2 has a variety of RNA substrates and plays an important role in mRNA metabolism. NSUN2 binds to specific sequences enriched in exosomal mRNAs, suggesting its possible involvement in the sorting of mRNAs into exosomes.
Olga A. Kossinova, Alexander V. Gopanenko, Elena S. Babaylova, Alexey E. Tupikin, Marsel R. Kabilov, Alexey A. Malygin, Galina G. Karpova   +6 more
openaire   +2 more sources

Aurora-B Regulates RNA Methyltransferase NSUN2 [PDF]

Molecular Biology of the Cell, 2007
Disassembly of the nucleolus during mitosis is driven by phosphorylation of nucleolar proteins. RNA processing stops until completion of nucleolar reformation in G1phase. Here, we describe the RNA methyltransferase NSUN2, a novel substrate of Aurora-B that contains an NOL1/NOP2/sun domain.
Shiho, Sakita-Suto, Akifumi, Kanda, Fumio, Suzuki, Sunao, Sato, Takashi, Takata, Masaaki, Tatsuka   +5 more
openaire   +2 more sources

It Takes NSUN2 to Beat the Heat in Rice [PDF]

Developmental Cell, 2020
Cytosine methylation (m5C) exists at low but significant levels in eukaryotic mRNAs, but its biological functions remain elusive. In this issue of Developmental Cell, Tang et al. find that the RNA methyltransferase OsNSUN2 is required for heat tolerance in rice by enhancing translation of specific transcripts under heat stress.
Zhaohai, Zhu, Heng, Zhang
openaire   +2 more sources

NSUN2-mediated m⁵C methylation modification regulates trophoblast cell proliferation, apoptosis, and autophagy in gestational diabetes mellitus. [PDF]

J Diabetes Investig
Introduction Gestational diabetes mellitus (GDM) represents one of the most prevalent medical complications during pregnancy. Emerging evidence has implicated NOL1/NOP2/SUN domain (NSUN)2‐mediated 5‐methylcytosine (m5C) methylation modifications in ...
Liu J, Chen Y, Wang D, Li Z.
europepmc   +2 more sources