Results 21 to 30 of about 2,411 (105)

NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation

Cell Death and Disease, 2021
The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the regulation of cell proliferation and metastasis formation and is upregulated in multiple cancers.
Yuanbo Hu, Chenbin Chen, Xinya Tong, Sian Chen, Xianjing Hu, Bujian Pan, Xiangwei Sun, Zhiyuan Chen, Xinyu Shi, Yingying Hu, Xian Shen, Xiangyang Xue, Mingdong Lu   +12 more
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NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m5C methylation

Cell Death and Disease, 2023
5-methylcytosine (m5C) modification, which is mainly induced by the RNA methyltransferase NSUN2 (NOP2/Sun domain family, member 2), is an important chemical posttranscriptional modification in mRNA and has been proven to play important roles in the ...
Min Yang, Renxiong Wei, Sheng Zhang, Sang Hu, Xiaoxiao Liang, Zhiqiang Yang, Chong Zhang, Yufeng Zhang, Lin Cai, Yuanlong Xie   +9 more
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NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections

Emerging Microbes and Infections, 2023
5-Methylcytosine (m5C) is a widespread post-transcriptional RNA modification and is reported to be involved in manifold cellular responses and biological processes through regulating RNA metabolism.
Hongyun Wang, Jiangpeng Feng, Cong Zeng, Jiejie Liu, Zhiying Fu, Dehe Wang, Yafen Wang, Lu Zhang, Jiali Li, Ao Jiang, Miao He, Yuanyuan Cao, Kun Yan, Hao Tang, Deyin Guo, Ke Xu, Xiang Zhou, Li Zhou, Ke Lan, Yu Zhou, Yu Chen   +20 more
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Distinct Roles of m5C RNA Methyltransferase NSUN2 in Major Gynecologic Cancers

Frontiers in Oncology, 2022
RNA methylation has recently emerged as an important category of epigenetic modifications, which plays diverse physiopathological roles in various cancers.
Lingfang Wang, Lingfang Wang, Jian Zhang, Yingfeng Su, Yasen Maimaitiyiming, Yasen Maimaitiyiming, Siqi Yang, Zhangjin Shen, Shitong Lin, Shizhen Shen, Guankai Zhan, Fenfen Wang, Chih-Hung Hsu, Xiaodong Cheng   +13 more
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Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer

Molecular Cancer, 2023
Background RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear.
Yueqin Wang, Jingyao Wei, Luyao Feng, Ouwen Li, Lan Huang, Shaoxuan Zhou, Yingjie Xu, Ke An, Yu Zhang, Ruiying Chen, Lulu He, Qiming Wang, Han Wang, Yue Du, Ruijuan Liu, Chunmin Huang, Xiaojian Zhang, Yun-gui Yang, Quancheng Kan, Xin Tian   +19 more
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NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma

Frontiers in Oncology, 2022
Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck with a complex etiology, such as environmental factors, genetic factors, and Epstein–Barr virus infection.
Xinya Tong, Yilan Xiang, Yuanbo Hu, Yuanbo Hu, Yingying Hu, Yingying Hu, He Li, Huilin Wang, Kong-Nan Zhao, Xiangyang Xue, Shanli Zhu   +10 more
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NSUN2-FOSB reciprocity facilitates leukemogenesis in an m5C-dependent manner by increasing BCL2L1 expression

Haematologica
NOP2/Sun RNA methyltransferase family member 2 (NSUN2) catalyzes 5-methylcytosine (m5C) modifications on RNA to regulate mRNA stability. However, its roles in normal hematopoiesis and leukemogenesis remain poorly understood.
Bin Zhou, Yigang Yuan, Yue Cai, Jingying Zhou, Liuzhi Shi, Yaqian Qin, Chen Meng, Shixin Zhang, Shirui Yu, Xinyao Chen, Xiaofei He, Shanshan Wu, Min Li, Xuanyu Yu, Yifen Shi, Chongyun Xing, Chiqi Chen, Meng Zhao, Shenmeng Gao   +18 more
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The m5C methyltransferase NSUN2 promotes codon‐dependent oncogenic translation by stabilising tRNA in anaplastic thyroid cancer

Clinical and Translational Medicine, 2023
Background Translation dysregulation plays a crucial role in tumourigenesis and cancer progression. Oncogenic translation relies on the stability and availability of tRNAs for protein synthesis, making them potential targets for cancer therapy.
Peng Li, Wenlong Wang, Ruixin Zhou, Ying Ding, Xinying Li   +4 more
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NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular Carcinoma

Genomics, Proteomics & Bioinformatics, 2023
RNA modifications affect many biological processes and physiological diseases. The 5-methylcytosine (m5C) modification regulates the progression of multiple tumors.
Dan Song, Ke An, Wenlong Zhai, Luyao Feng, Yingjie Xu, Ran Sun, Yueqin Wang, Yun-Gui Yang, Quancheng Kan, Xin Tian   +9 more
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NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB‐STAT3 signalling in a non‐m5C manner

Clinical and Translational Medicine
NSUN2, a major methyltransferase that catalyzes m5C methylation in eukaryotes, is known to be implicated in the development of multiple cancers. However, its role in colorectal cancer (CRC) and the related molecular mechanisms have yet to be sufficiently
Yuanbo Hu, Chenbin Chen, Kezhi Lin, Xinya Tong, Tingting Huang, Tianle Qiu, Xietao Chen, Jun Xu, Wangkai Xie, Xiangwei Sun, Shiyu Feng, Mingdong Lu, Zhiguang Zhao, Xiaodong Chen, Xiangyang Xue, Xian Shen   +15 more
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