Results 21 to 30 of about 2,920 (152)

NSUN2-Mediated m⁵C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA. [PDF]

Adv Sci (Weinh)
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Zhu X, Liu X, Yu X, Han Q, Shi F, Song W, Liu L, Chu C, Shen C, Zhang Z, Li X.   +10 more
europepmc   +2 more sources

Metabolic Recoding of NSUN2-Mediated m5C Modification Promotes the Progression of Colorectal Cancer via the NSUN2/YBX1/m5C-ENO1 Positive Feedback Loop

Advanced Science
The RNA modification, 5‐methylcytosine (m5C), has recently gained prominence as a pivotal post‐transcriptional regulator of gene expression, intricately intertwined with various tumorigenic processes.
Congqing Jiang, Baoxiang Chen, Siyuan Yin   +2 more
exaly   +2 more sources

NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m5C methylation

Journal of Translational Medicine
Background Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and retinal traction, thereby ...
Runze Wang, Wei Xue, Feifei Kan, Huiying Zhang, Di Wang, Lei Wang, Jianwen Wang   +6 more
doaj   +2 more sources

NSUN2 restrains gastric cancer cell apoptosis and ferroptosis by promoting the m5C modification of EPYC [PDF]

Hereditas
Background Epiphycan (EPYC) has been confirmed to play an oncogenic role in many cancers. However, its role and mechanism in gastric cancer (GC) progression has not been explored.
Lei Wu, Boxuan Chen, Si Cheng, Xiaofeng Fang, Fen Zhou   +4 more
doaj   +2 more sources

m⁵C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6-Mediated Wnt/β-catenin Signaling Pathway. [PDF]

Adv Sci (Weinh)
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Hao L, Zhang J, Qian Q, Jiang M, Liu Y, Geng Y, Cui N, Guo Q, Guo J.   +8 more
europepmc   +2 more sources

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2-m5C Modified ATF4 mRNA. [PDF]

Cancer Sci
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Li Y, Li S, Li Y, Pan Z.
europepmc   +2 more sources

NOP2/Sun RNA methyltransferase 2 is a potential pan-cancer prognostic biomarker and is related to immunity.

PLoS ONE, 2023
BackgroundNOP2/Sun RNA methyltransferase 2 (NSUN2), an important methyltransferase of m5C, has been poorly studied in cancers, and the relationship between NSUN2 and immunity remains largely unclear.
Lemei Zheng, Mengna Li, Jianxia Wei, Shipeng Chen, Changning Xue, Yumei Duan, Faqing Tang, Guiyuan Li, Wei Xiong, Kelin She, Hongyu Deng, Ming Zhou   +11 more
doaj   +1 more source

Multi-omics analysis of expression and prognostic value of NSUN members in prostate cancer

Frontiers in Oncology, 2022
BackgroundProstate cancer is the most common tumor in men worldwide, seriously threatening the health of older men, and 5-methylcytosine (m5C) RNA modification has been shown to have a significant impact on the development and progression of various ...
Guangyu Sun, Shenfei Ma, Zhiwen Zheng, Xiaohua Wang, Shuaiqi Chen, Taihao Chang, Zhengxin Liang, Yuchen Jiang, Shengxian Xu, Ranlu Liu   +9 more
doaj   +1 more source

Positive epigenetic regulation loop between AR and NSUN2 promotes prostate cancer progression

Clinical and Translational Medicine, 2022
Background Prostate cancer (PCa) is a major type of cancer in man worldwide. Androgen deprivation therapy (ADT) and the next‐generation androgen receptor (AR) pathway inhibitors have acquired great success in treating PCa.
Wenkai Zhu, Fangning Wan, Wenhao Xu, Zheng Liu, Junjie Wang, Hena Zhang, Shenglin Huang, Dingwei Ye   +7 more
doaj   +1 more source

NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer

Cell Death Discovery, 2023
NSUN2 is a nuclear RNA methyltransferase which catalyzes 5-methylcytosine (m5C), a posttranscriptional RNA modification. Aberrant m5C modification has been implicated in the development of multiple malignancies. However, its function in pancreatic cancer
Guizhen Zhang, Liwen Liu, Jianhao Li, Yu Chen, Yun Wang, Yize Zhang, Zihui Dong, Wenhua Xue, Ranran Sun, Guangying Cui   +9 more
doaj   +1 more source