NSUN2-tRNA<sup>Val-CAC</sup>-axis-regulated codon-biased translation drives triple-negative breast cancer glycolysis and progression. [PDF]
Cell Mol Biol LettBackground Epitranscriptomic data indicate that aberrant tRNA modifications in malignant diseases can promote tumor growth by facilitating oncogene translation.
Wang W +5 more
europepmc +2 more sources
Environment InternationalHexavalent chromium [Cr(VI)], one common environmental contaminant, has long been recognized as a carcinogen associated with lung cancer, but roles and mechanisms of Cr(VI)-induced epigenetic dysregulations in carcinogenesis remain to be investigated. In
Rui-Ke Zhang +9 more
exaly +3 more sources
Impaired hippocampal NMDAR-LTP in a transgenic model of NSUN2-deficiency [PDF]
Neurobiology of Disease, 2022 Biallelic loss-of-function NSUN2 mutations have recently been associated with cases of Autism Spectrum Condition (ASC), and NSun2-deficiency was also previously shown to cause a severe autosomal recessive intellectually disability disorder syndrome in ...
Bashir, Zafar I. +2 more
core +7 more sources
Oncogenic and immunological roles of NSUN2 in triple negative breast cancer. [PDF]
Sci RepImmunotherapy have led to clinical remissions in many solid tumors. However, the efficacy of immunotherapeutic monotherapy in triple-negative breast cancer (TNBC) is not very satisfactory. NSUN2 functions as a proto-oncogene in various cancers, promoting
An N +8 more
europepmc +2 more sources
NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming. [PDF]
Cancer MetabPurpose Cancer cells rely on serine biosynthesis for growth, but its regulation in colorectal cancer (CRC) remains not well understood. This study identifies the m5C methyltransferase NSUN2 (NOP2/Sun domain family, member 2) as a key regulator of serine ...
Li H +7 more
europepmc +2 more sources
Enoxaparin alleviates preeclampsia by enhancing trophoblast function via the NSUN2-mediated m<sup>5</sup>C methylation of PAX3 mRNA. [PDF]
Eur J Med ResObjective Preeclampsia (PE), a complex multisystem disorder, is a major contributor to maternal and perinatal morbidity and mortality. Enoxaparin, a low-molecular-weight heparin, has shown therapeutic efficacy in preventing various diseases.
Zhong X, Zeng D.
europepmc +2 more sources
NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis
Molecular CancerRNA 5-methylcytosine (m5C), a prevalent epitranscriptomic modification that critically regulates gene expression and cellular homeostasis. While its roles in solid tumors have been increasingly recognized, the functional landscape of m5C in acute myeloid
Hong-Yan Tong
exaly +2 more sources
NSUN2 facilitates DICER cleavage of DNA damage-associated R-loops to promote repair. [PDF]
Nat CommunDNA integrity is constantly challenged by both endogenous and exogenous damaging agents, resulting in various forms of damage. Failure to repair DNA accurately leads to genomic instability, a hallmark of cancer.
Alagia A +4 more
europepmc +3 more sources
Redox BiologyEndometrial cancer (EC) is a prevalent gynecological malignancy worldwide, and 5-methylcytosine (m5C) modification of mRNA is a crucial epigenetic modification associated with the development and occurrence of several cancers.
exaly +3 more sources
NSUN2-mediated RNA m5C modification modulates uveal melanoma cell proliferation and migration
Epigenetics, 2022 RNA 5-methylcytosine (m5C) is a widespread post-transcriptional modification involved in diverse biological processes through controlling RNA metabolism. However, its roles in uveal melanoma (UM) remain unknown. Here, we describe the biological roles and
Guangying Luo +8 more
doaj +3 more sources