Results 21 to 30 of about 2,478 (156)
A novel variant in NSUN2 causes intellectual disability in a Chinese family
BMC Medical Genomics, 2023 NSUN2-intellectual disability syndrome, also known as intellectual disability type 5 (MRT5), is an autosomal recessive disorder that is characterized by intellectual disability (ID), postnatal growth retardation, dysmorphic facies, microcephaly, short ...
Qi Yang +4 more
doaj +3 more sources
Redox BiologyEndometrial cancer (EC) is a prevalent gynecological malignancy worldwide, and 5-methylcytosine (m5C) modification of mRNA is a crucial epigenetic modification associated with the development and occurrence of several cancers.
Shuai-Jun Chen, Hongfeng Zhang
exaly +3 more sources
Unveiling the potential impact of RNA m5C methyltransferases NSUN2 and NSUN6 on cellular aging
Frontiers in GeneticsNSUN2 and NSUN6, two family members of NOL1/NSUN protein, are mainly responsible for catalyzing the formation of 5-methylcytosine (m5C) in RNA and highly involved in the physiological and pathological processes of many diseases.
Jiale Zhou +7 more
doaj +3 more sources
It Takes NSUN2 to Beat the Heat in Rice [PDF]
Developmental Cell, 2020 Cytosine methylation (m5C) exists at low but significant levels in eukaryotic mRNAs, but its biological functions remain elusive. In this issue of Developmental Cell, Tang et al. find that the RNA methyltransferase OsNSUN2 is required for heat tolerance in rice by enhancing translation of specific transcripts under heat stress.
Zhaohai, Zhu, Heng, Zhang
openaire +2 more sources
Substrate selectivity of the human RNA m<sup>5</sup>C methyltransferase NSUN2. [PDF]
NatureCanepa J +3 more
europepmc +2 more sources
PLoS ONE, 2023 BackgroundNOP2/Sun RNA methyltransferase 2 (NSUN2), an important methyltransferase of m5C, has been poorly studied in cancers, and the relationship between NSUN2 and immunity remains largely unclear.
Lemei Zheng +11 more
doaj +1 more source
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer [PDF]
Cells, 2020 5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also found increasingly in a plethora of RNA species, predominantly transfer RNAs, but increasingly found in cytoplasmic and mitochondrial ribosomal RNAs, enhancer RNAs, and a number of long noncoding RNAs.
Anitha Chellamuthu, Steven G. Gray
openaire +3 more sources
Multi-omics analysis of expression and prognostic value of NSUN members in prostate cancer
Frontiers in Oncology, 2022 BackgroundProstate cancer is the most common tumor in men worldwide, seriously threatening the health of older men, and 5-methylcytosine (m5C) RNA modification has been shown to have a significant impact on the development and progression of various ...
Guangyu Sun +9 more
doaj +1 more source
Positive epigenetic regulation loop between AR and NSUN2 promotes prostate cancer progression
Clinical and Translational Medicine, 2022 Background Prostate cancer (PCa) is a major type of cancer in man worldwide. Androgen deprivation therapy (ADT) and the next‐generation androgen receptor (AR) pathway inhibitors have acquired great success in treating PCa.
Wenkai Zhu +7 more
doaj +1 more source
Aurora-B Regulates RNA Methyltransferase NSUN2 [PDF]
Molecular Biology of the Cell, 2007 Disassembly of the nucleolus during mitosis is driven by phosphorylation of nucleolar proteins. RNA processing stops until completion of nucleolar reformation in G1phase. Here, we describe the RNA methyltransferase NSUN2, a novel substrate of Aurora-B that contains an NOL1/NOP2/sun domain.
Shiho, Sakita-Suto +5 more
openaire +2 more sources