Results 1 to 10 of about 5,826 (107)

NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA [PDF]

Scientific Reports
RNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers.
Yang Jiang, Jing Sun, Yuyan Chen, Lin Cheng, Saran Feng, Yan Wang, Congcong Sun   +6 more
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NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication. [PDF]

PLoS Pathogens, 2023
Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis and liver cancer, despite strong prevention and treatment efforts.
Jiangpeng Feng, Tianmo Xu, Miao He, Jiali Li, Peipei Yao, Chengbao Ma, Shimin Yang, Zaichao Xu, Kun Yan, Xianying Chen, Hongyun Wang, Jiejie Liu, Cong Zeng, Yuchen Xia, Huan Yan, Li Zhou, Yu Chen   +16 more
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5-Methylcytosine (m5C) Modification Patterns and Tumor Immune Infiltration Characteristics in Clear Cell Renal Cell Carcinoma [PDF]

Current Oncology, 2022
Recently, studies have revealed the prognostic value of 5-methylcytosine (m5C) in clear cell renal cell carcinoma (ccRCC). However, the role of m5C methylation in ccRCC immune infiltration and the immunotherapeutic response remains unknown.
Can Chen, Lin-Yuan Chen, Jie-Xin Zhang, Hua-Guo Xu   +3 more
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Vital roles of m5C RNA modification in cancer and immune cell biology

Frontiers in Immunology, 2023
RNA modification plays an important role in epigenetics at the posttranscriptional level, and 5-methylcytosine (m5C) has attracted increasing attention in recent years due to the improvement in RNA m5C site detection methods. By influencing transcription,
Xinyu Gu, Xiao Ma, Chao Chen, Jun Guan, Jing Wang, Shanshan Wu, Haihong Zhu   +6 more
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Roles of m5C RNA Modification Patterns in Biochemical Recurrence and Tumor Microenvironment Characterization of Prostate Adenocarcinoma

Frontiers in Immunology, 2022
BackgroundProstate cancer is the second most common cancer with a high risk of biochemical recurrence (BCR) among men. Recently, 5-methylcytosine (m5C) modification has attracted more attention as a new layer of RNA post-transcriptional regulation. Hence,
Zhipeng Xu, Zhipeng Xu, Shuqiu Chen, Shuqiu Chen, Yuxi Zhang, Ruiji Liu, Ruiji Liu, Ruiji Liu, Ming Chen, Ming Chen, Ming Chen   +10 more
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RNA m5C methylation modification: a potential therapeutic target for SARS-CoV-2-associated myocarditis

Frontiers in Immunology
The Corona Virus Disease (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has quickly spread worldwide and resulted in significant morbidity and mortality.
Yan Xiong, Yan Xiong, Yanan Li, Weiwei Qian, Weiwei Qian, Qing Zhang   +5 more
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m5C regulator‐mediated methylation modification patterns and tumor microenvironment infiltration characteristics in acute myeloid leukemia

Immunity, Inflammation and Disease
Background Recently, many studies have been conducted to examine immune response modification at epigenetic level, but the candidate effect of RNA 5‐methylcytosine (m5C) modification on tumor microenvironment (TME) of acute myeloid leukemia (AML) is ...
Qiang Wen, ShouJun Wang, Lili Hong, Siyu Shen, Yibo He, Xianfu Sheng, Xiaofen Zhuang, Shiliang Chen, Ying Wang, Haifeng Zhuang   +9 more
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RNA m5C modification: from physiology to pathology and its biological significance [PDF]

Frontiers in Immunology
RNA 5-methylcytosine (m5C) modification is a crucial epitranscriptomic mark that regulates RNA stability, processing, and translation. Emerging evidence highlights its essential role in various physiological processes, including cellular differentiation,
Xi Chen, Xi Chen, Yixiao Yuan, Fan Zhou, Xiaobing Huang, Xiaobing Huang, Lihua Li, Jun Pu, Jun Pu, Yong Zeng, Xiulin Jiang   +10 more
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NSUN2‐mediated m5C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression

Clinical and Translational Medicine, 2023
Background The precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism, and is necessary for the maintenance of epigenome homeostasis.
Sipeng Zuo, Lin Li, Xuyang Wen, Xiang Gu, Ai Zhuang, Rui Li, Fuxiang Ye, Shengfang Ge, Xianqun Fan, Jiayan Fan, Peiwei Chai, Linna Lu   +11 more
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RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer [PDF]

Experimental and Molecular Medicine
5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional ...
Xiaoyi Liu, Qinglv Wei, Chenyue Yang, Hongyan Zhao, Jie Xu, Youchaou Mobet, Qingya Luo, Dan Yang, Xinzhao Zuo, Ningxuan Chen, Yu Yang, Li Li, Wei Wang, Jianhua Yu, Jing Xu, Tao Liu, Ping Yi   +16 more
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