Results 1 to 10 of about 6,251 (129)

NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA [PDF]

Scientific Reports
RNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers.
Yang Jiang, Jing Sun, Yuyan Chen, Lin Cheng, Saran Feng, Yan Wang, Congcong Sun   +6 more
doaj   +3 more sources

NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication. [PDF]

PLoS Pathogens, 2023
Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis and liver cancer, despite strong prevention and treatment efforts.
Jiangpeng Feng, Tianmo Xu, Miao He, Jiali Li, Peipei Yao, Chengbao Ma, Shimin Yang, Zaichao Xu, Kun Yan, Xianying Chen, Hongyun Wang, Jiejie Liu, Cong Zeng, Yuchen Xia, Huan Yan, Li Zhou, Yu Chen   +16 more
doaj   +2 more sources

NSUN2-Mediated m⁵C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA. [PDF]

Adv Sci (Weinh)
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Zhu X, Liu X, Yu X, Han Q, Shi F, Song W, Liu L, Chu C, Shen C, Zhang Z, Li X.   +10 more
europepmc   +2 more sources

NSUN2-mediated m5C modification of HIV-1 RNA enables evasion of RIG‑I‑dependent innate immunity. [PDF]

PLoS Pathogens
Recently, 5-methylcytosine (m5C) modification has been identified in HIV-1 genomic RNA. However, the functional role of this RNA modification in the antiviral innate immune response remains unclear.
Yuebo Xu, Mingyang Li, Yingying Song, Weili Kong, Jingjing Song, Jiali Zhang, Xinmu Xu, Haoyu Ma, Shun Yu, Shuliang Chen, Cong Zeng   +10 more
doaj   +2 more sources

Vital roles of m5C RNA modification in cancer and immune cell biology

Frontiers in Immunology, 2023
RNA modification plays an important role in epigenetics at the posttranscriptional level, and 5-methylcytosine (m5C) has attracted increasing attention in recent years due to the improvement in RNA m5C site detection methods. By influencing transcription,
Xinyu Gu, Xiao Ma, Chao Chen, Jun Guan, Jing Wang, Shanshan Wu, Haihong Zhu   +6 more
doaj   +3 more sources

Roles of m5C RNA Modification Patterns in Biochemical Recurrence and Tumor Microenvironment Characterization of Prostate Adenocarcinoma

Frontiers in Immunology, 2022
BackgroundProstate cancer is the second most common cancer with a high risk of biochemical recurrence (BCR) among men. Recently, 5-methylcytosine (m5C) modification has attracted more attention as a new layer of RNA post-transcriptional regulation. Hence,
Zhipeng Xu, Zhipeng Xu, Shuqiu Chen, Shuqiu Chen, Yuxi Zhang, Ruiji Liu, Ruiji Liu, Ruiji Liu, Ming Chen, Ming Chen, Ming Chen   +10 more
doaj   +3 more sources

m5C regulator‐mediated methylation modification patterns and tumor microenvironment infiltration characteristics in acute myeloid leukemia

Immunity, Inflammation and Disease
Background Recently, many studies have been conducted to examine immune response modification at epigenetic level, but the candidate effect of RNA 5‐methylcytosine (m5C) modification on tumor microenvironment (TME) of acute myeloid leukemia (AML) is ...
Qiang Wen, ShouJun Wang, Lili Hong, Siyu Shen, Yibo He, Xianfu Sheng, Xiaofen Zhuang, Shiliang Chen, Ying Wang, Haifeng Zhuang   +9 more
doaj   +2 more sources

NSUN2‐mediated m5C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression

Clinical and Translational Medicine, 2023
Background The precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism, and is necessary for the maintenance of epigenome homeostasis.
Sipeng Zuo, Lin Li, Xuyang Wen, Xiang Gu, Ai Zhuang, Rui Li, Fuxiang Ye, Shengfang Ge, Xianqun Fan, Jiayan Fan, Peiwei Chai, Linna Lu   +11 more
doaj   +2 more sources

RNA m5C modification: from physiology to pathology and its biological significance [PDF]

Frontiers in Immunology
RNA 5-methylcytosine (m5C) modification is a crucial epitranscriptomic mark that regulates RNA stability, processing, and translation. Emerging evidence highlights its essential role in various physiological processes, including cellular differentiation,
Xi Chen, Xi Chen, Yixiao Yuan, Fan Zhou, Xiaobing Huang, Xiaobing Huang, Lihua Li, Jun Pu, Jun Pu, Yong Zeng, Xiulin Jiang   +10 more
doaj   +2 more sources

Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma

Frontiers in Cell and Developmental Biology, 2021
The tumor microenvironment (TME) affects the biologic malignancy of clear cell renal cell carcinoma (ccRCC). The influence of the 5-methylcytosine (m5C) epigenetic modification on the TME is unknown.
Wenhao Xu, Wenhao Xu, Wenkai Zhu, Wenkai Zhu, Xi Tian, Xi Tian, Wangrui Liu, Yuanyuan Wu, Aihetaimujiang Anwaier, Aihetaimujiang Anwaier, Jiaqi Su, Jiaqi Su, Shiyin Wei, Yuanyuan Qu, Yuanyuan Qu, Hailiang Zhang, Hailiang Zhang, Dingwei Ye, Dingwei Ye   +18 more
doaj   +1 more source