Results 11 to 20 of about 5,895 (158)
Frontiers in Surgery, 2023 BackgroundRecent studies have found that 5-methylcytosine (m5C) modulators are associated with the prognosis and treatment of cancer. However, the relevance of m5C modulators in sarcoma prognosis and the tumour microenvironment is unclear.MethodsWe ...
Shusheng Wu +5 more
doaj +3 more sources
m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets
Journal of Translational Medicine5-Methylcytosine (m5C), an important RNA modification, has been extensively studied in colorectal cancer (CRC). In recent years, with advances in high-throughput sequencing technology and RNA modification detection tools, the role of m5C modification in ...
Jiawei Wang +5 more
doaj +3 more sources
Mediators of Inflammation, 2023 Background. 5-Methylcytosine (m5C) RNA modification is closely implicated in the occurrence of a variety of cancers. Here, we established a novel prognostic signature for ovarian cancer (OC) patients based on m5C RNA modification-related genes and ...
Yibin Liu +6 more
doaj +3 more sources
The RNA m5C modification in R-loops as an off switch of Alt-NHEJ. [PDF]
Nat Commun, 2023 AbstractThe roles of R-loops and RNA modifications in homologous recombination (HR) and other DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find that DNA damage-induced RNA methyl-5-cytosine (m5C) modification in R-loops plays a crucial role to regulate PARP1-mediated poly ADP-ribosylation (PARylation) and the ...
Yang H +11 more
europepmc +4 more sources
Epigenetically upregulated NSUN2 confers ferroptosis resistance in endometrial cancer via m5C modification of SLC7A11 mRNA [PDF]
Redox BiologyEndometrial cancer (EC) is a prevalent gynecological malignancy worldwide, and 5-methylcytosine (m5C) modification of mRNA is a crucial epigenetic modification associated with the development and occurrence of several cancers.
Shuai-Jun Chen +7 more
doaj +2 more sources
m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation. [PDF]
Cell Death Dis, 2023 AbstractCancer immunotherapy is arguably the most rapidly advancing realm of cancer treatment. Glutathione peroxidase 4 (GPX4) has emerged as the vital enzyme to prevent lipid peroxidation and maintain cellular redox homeostasis. However, the mechanism of GPX4 in the regulation of cancer immunotherapy of colon adenocarcinoma (COAD) are incompletely ...
Chen B +9 more
europepmc +4 more sources
RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression. [PDF]
NPJ Precis Oncol5-methylcytosine (m5C) RNA modification plays critical roles in post-transcriptional regulation and cancer progression. However, the downstream effectors of the m5C reader protein YBX1 and their mechanistic contribution to hepatocellular carcinoma (HCC) remain largely undefined.
Li J, Chen H, Bai L, Tang H.
europepmc +3 more sources
Development and Validation of a Novel Gene Signature for Predicting the Prognosis by Identifying m5C Modification Subtypes of Cervical Cancer [PDF]
Frontiers in Genetics, 2021 Jing Yu, Lin Xiu, Jia Zeng
exaly +2 more sources
Comprehensive analysis of key m5C modification-related genes in type 2 diabetes. [PDF]
Front Genet, 2022 Background: 5-methylcytosine (m5C) RNA methylation plays a significant role in several human diseases. However, the functional role of m5C in type 2 diabetes (T2D) remains unclear.Methods: The merged gene expression profiles from two Gene Expression Omnibus (GEO) datasets were used to identify m5C-related genes and T2D-related differentially expressed ...
Song Y +7 more
europepmc +4 more sources
Isoimperatorin improves osteoporosis by increasing YBX1 expression to promote BGLAP m5C modification. [PDF]
Sci RepOsteoporosis is a chronic metabolic bone disease that is prone to fractures. Isoimperatorin (ISO) has been shown to alleviate the bone loss in ovariectomized (OVX) rats. The aim of this study was to investigate the effect and the mechanism of ISO on osteoporosis using animal study and cell experiments.
Hu G, Wen J, Yang H, Zhang K.
europepmc +4 more sources