Results 11 to 20 of about 8,203 (227)

RNA m5C methylation modification: a potential therapeutic target for SARS-CoV-2-associated myocarditis

Frontiers in Immunology
The Corona Virus Disease (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has quickly spread worldwide and resulted in significant morbidity and mortality.
Yan Xiong, Yan Xiong, Yanan Li, Weiwei Qian, Weiwei Qian, Qing Zhang   +5 more
doaj   +5 more sources

m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation. [PDF]

Cell Death Dis, 2023
AbstractCancer immunotherapy is arguably the most rapidly advancing realm of cancer treatment. Glutathione peroxidase 4 (GPX4) has emerged as the vital enzyme to prevent lipid peroxidation and maintain cellular redox homeostasis. However, the mechanism of GPX4 in the regulation of cancer immunotherapy of colon adenocarcinoma (COAD) are incompletely ...
Chen B, Hong Y, Zhai X, Deng Y, Hu H, Tian S, Zhang Y, Ren X, Zhao J, Jiang C.   +9 more
europepmc   +6 more sources

Dynamics of RNA m⁵C modification during brain development. [PDF]

Genomics, 2023
Post-transcriptional RNA modifications have been recognized as key regulators of neuronal differentiation and synapse development in the mammalian brain. While distinct sets of 5-methylcytosine (m5C) modified mRNAs have been detected in neuronal cells and brain tissues, no study has been performed to characterize methylated mRNA profiles in the ...
Johnson Z, Xu X, Lin Y, Xie H.
europepmc   +5 more sources

Folate regulates RNA m⁵C modification and translation in neural stem cells. [PDF]

BMC Biol, 2022
Abstract Background Folate is an essential B-group vitamin and a key methyl donor with important biological functions including DNA methylation regulation. Normal neurodevelopment and physiology are sensitive to the cellular folate levels. Either deficiency or excess of folate may lead to neurological disorders. Recently,
Xu X, Johnson Z, Wang A, Padget RL, Smyth JW, Xie H.   +5 more
europepmc   +7 more sources

Roles of m5C RNA Modification Patterns in Biochemical Recurrence and Tumor Microenvironment Characterization of Prostate Adenocarcinoma

Frontiers in Immunology, 2022
BackgroundProstate cancer is the second most common cancer with a high risk of biochemical recurrence (BCR) among men. Recently, 5-methylcytosine (m5C) modification has attracted more attention as a new layer of RNA post-transcriptional regulation. Hence,
Zhipeng Xu, Zhipeng Xu, Shuqiu Chen, Shuqiu Chen, Yuxi Zhang, Ruiji Liu, Ruiji Liu, Ruiji Liu, Ming Chen, Ming Chen, Ming Chen   +10 more
doaj   +3 more sources

Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer

Molecular Cancer, 2023
Background RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear.
Yueqin Wang, Jingyao Wei, Luyao Feng, Ouwen Li, Lan Huang, Shaoxuan Zhou, Yingjie Xu, Ke An, Yu Zhang, Ruiying Chen, Lulu He, Qiming Wang, Han Wang, Yue Du, Ruijuan Liu, Chunmin Huang, Xiaojian Zhang, Yun-gui Yang, Quancheng Kan, Xin Tian   +19 more
doaj   +2 more sources

m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets

Journal of Translational Medicine
5-Methylcytosine (m5C), an important RNA modification, has been extensively studied in colorectal cancer (CRC). In recent years, with advances in high-throughput sequencing technology and RNA modification detection tools, the role of m5C modification in ...
Jiawei Wang, Cenyi Qi, Ran Wang, Yuepeng Cao, Yuping Zhou, Guoliang Ye   +5 more
doaj   +2 more sources

Developmental mRNA m5C landscape and regulatory innovations of massive m5C modification of maternal mRNAs in animals

Nature Communications, 2022
Abstractm5C is one of the longest-known RNA modifications, however, its developmental dynamics, functions, and evolution in mRNAs remain largely unknown. Here, we generate quantitative mRNA m5C maps at different stages of development in 6 vertebrate and invertebrate species and find convergent and unexpected massive methylation of maternal mRNAs ...
Jianheng Liu, Tao Huang, Wanying Chen, Chenhui Ding, Tianxuan Zhao, Xueni Zhao, Bing Cai, Yusen Zhang, Song Li, Ling Zhang, Maoguang Xue, Xiuju He, Wanzhong Ge, Canquan Zhou, Yanwen Xu, Rui Zhang   +15 more
openaire   +5 more sources

FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation

Proceedings of the National Academy of Sciences, 2022
Significance This study shows that Fragile X mental retardation protein (FMRP) promotes messenger RNA (mRNA)-dependent recombination via facilitating ten-eleven translocation protein 1 (TET1)-mediated mRNA methyl-5-cytosine (m5C) demethylation.
Haibo Yang, Yumin Wang, Yufei Xiang, Tribhuwan Yadav, Jian Ouyang, Laiyee Phoon, Xueping Zhu, Yi Shi, Lee Zou, Li Lan   +9 more
openaire   +4 more sources

Prediction of m5C Modifications in RNA Sequences by Combining Multiple Sequence Features [PDF]

Molecular Therapy Nucleic Acids, 2020
5-Methylcytosine (m5C) is a well-known post-transcriptional modification that plays significant roles in biological processes, such as RNA metabolism, tRNA recognition, and stress responses. Traditional high-throughput techniques on identification of m5C sites are usually time consuming and expensive.
Lijun Dou, Xiaoling Li, Hui Ding, Lei Xu, Huaikun Xiang   +4 more
openalex   +4 more sources