Results 11 to 20 of about 814,114 (202)

m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets

Journal of Translational Medicine
5-Methylcytosine (m5C), an important RNA modification, has been extensively studied in colorectal cancer (CRC). In recent years, with advances in high-throughput sequencing technology and RNA modification detection tools, the role of m5C modification in ...
Jiawei Wang, Cenyi Qi, Ran Wang, Yuepeng Cao, Yuping Zhou, Guoliang Ye   +5 more
doaj   +4 more sources

Modification of m5C regulators in sarcoma can guide different immune infiltrations as well as immunotherapy [PDF]

Frontiers in Surgery, 2023
BackgroundRecent studies have found that 5-methylcytosine (m5C) modulators are associated with the prognosis and treatment of cancer. However, the relevance of m5C modulators in sarcoma prognosis and the tumour microenvironment is unclear.MethodsWe ...
Shusheng Wu, Mengge Li, Rixin Su, Hao Shen, Yifu He, Yangfan Zhou   +5 more
doaj   +4 more sources

5-Methylcytosine (m5C) Modification Patterns and Tumor Immune Infiltration Characteristics in Clear Cell Renal Cell Carcinoma

Current Oncology, 2022
Recently, studies have revealed the prognostic value of 5-methylcytosine (m5C) in clear cell renal cell carcinoma (ccRCC). However, the role of m5C methylation in ccRCC immune infiltration and the immunotherapeutic response remains unknown.
Can Chen, Lin-Yuan Chen, Jie-Xin Zhang, Hua-Guo Xu   +3 more
doaj   +2 more sources

m5C regulator-mediated methylation modification phenotypes characterized by distinct tumor microenvironment immune heterogenicity in colorectal cancer

Scientific Reports, 2023
The RNA 5-methylcytosine (m5C) modification has been demonstrated to be an important epigenetic regulator and to impact colorectal cancer (CRC) progression.
Zhihua Chen, Quanfa Li, Yilin Lin, Suyong Lin, Ji Gao, Shaoqin Chen   +5 more
doaj   +2 more sources

Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing [PDF]

International Journal of Genomics, 2018
Background. Compared with the well-studied 5-methylcytosine (m5C) in DNA, the role and topology of epitranscriptome m5C remain insufficiently characterized. Results.
Zhen Wei, Subbarayalu Panneerdoss, Santosh Timilsina, Jingting Zhu, Tabrez A. Mohammad, Zhi-Liang Lu, João Pedro de Magalhães, Yidong Chen, Rong Rong, Yufei Huang, Manjeet K. Rao, Jia Meng   +11 more
doaj   +2 more sources

Lactylation-Boosted m5C RNA Modification Drives Choroidal Neovascularization

Research
As a prevalent posttranscriptional RNA modification, N5-methylcytosine (m5C) plays a crucial role in a multitude of cellular responses and processes that govern RNA metabolism.
Sipeng Zuo, Lin Li, Jieling Tang, Fuxiang Ye, Sok, Yan Liu, Shengfang Ge, Renbing Jia, Xianqun Fan, Peiwei Chai, Linna Lu   +10 more
doaj   +2 more sources

Recent research advances in RNA m5C methylation modification in liver diseases

Frontiers in Molecular Biosciences
RNA m5C methylation refers to the process wherein the 5th carbon atom of cytosine in RNA molecules is methylated by the action of methyltransferase, thus forming 5-methylcytosine (m5C).
Penghui Li, Shujun Zhang, Xinjun Hu, Wenjuan Chen, Lifan Zhang, Yafeng Liu, Xinyu Gu   +6 more
core   +3 more sources

RNA m5C methylation modification: a potential therapeutic target for SARS-CoV-2-associated myocarditis

Frontiers in Immunology
The Corona Virus Disease (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has quickly spread worldwide and resulted in significant morbidity and mortality.
Yan Xiong, Yan Xiong, Yanan Li, Weiwei Qian, Weiwei Qian, Qing Zhang   +5 more
doaj   +3 more sources

Contribution of m5C RNA Modification-Related Genes to Prognosis and Immunotherapy Prediction in Patients with Ovarian Cancer

Mediators of Inflammation, 2023
Background. 5-Methylcytosine (m5C) RNA modification is closely implicated in the occurrence of a variety of cancers. Here, we established a novel prognostic signature for ovarian cancer (OC) patients based on m5C RNA modification-related genes and ...
Wenhua Liu, Shikai Liu, Shouze Liu, Yibin Liu, Qianqian Zhang, Lu Yan, Xianghua Huang   +6 more
core   +4 more sources

The RNA m5C modification in R-loops as an off switch of Alt-NHEJ. [PDF]

Nat Commun, 2023
AbstractThe roles of R-loops and RNA modifications in homologous recombination (HR) and other DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find that DNA damage-induced RNA methyl-5-cytosine (m5C) modification in R-loops plays a crucial role to regulate PARP1-mediated poly ADP-ribosylation (PARylation) and the ...
Yang H, Lachtara EM, Ran X, Hopkins J, Patel PS, Zhu X, Xiao Y, Phoon L, Gao B, Zou L, Lawrence MS, Lan L.   +11 more
europepmc   +4 more sources