Recent research advances in RNA m5C methylation modification in liver diseases [PDF]
Frontiers in Molecular BiosciencesRNA m5C methylation refers to the process wherein the 5th carbon atom of cytosine in RNA molecules is methylated by the action of methyltransferase, thus forming 5-methylcytosine (m5C).
Wenjuan Chen +11 more
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RNA m5C methylation: a potential modulator of innate immune pathways in hepatocellular carcinoma [PDF]
Frontiers in ImmunologyRNA 5-methylcytosine (m5C) methylation plays a crucial role in hepatocellular carcinoma (HCC). As reported, aberrant m5C methylation is closely associated with the progression, therapeutic efficacy, and prognosis of HCC.
Shanfeng Li
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NSUN2 facilitates tenogenic differentiation of rat tendon-derived stem cells via m5C methylation of KLF2 [PDF]
Regenerative TherapyIntroduction: Tendon-derived stem cells (TDSCs) play a critical role in tendon repair. N5-methylcytosine (m5C) is a key regulator of cellular processes such as differentiation. This study aimed to investigate the impact of m5C on TDSC differentiation and
Wei Lin +4 more
exaly +5 more sources
RNA m5C methylation in cancer: mechanisms and biological impact [PDF]
OncogenesisRNA modification, a prominent epigenetic mechanism, has been implicated in regulating RNA function, stability, processing, and interactions, including pseudouridylation, acetylation, and methylation. Recent evidence highlights that 5-methylcytosine (m5C)
Zhenyu Guan +3 more
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The Role of NSUN Family Genes in m5C Methylation and Diseases [PDF]
Biomedicines5-Methylcytosine (m5C) methylation is a widely present nucleic acid modification in various RNAs and is a reversible epigenetic modification that affects RNA stability, nuclear export, and translation processes.
Tao Jiang +3 more
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RNA m5C methylation modification: a potential therapeutic target for SARS-CoV-2-associated myocarditis [PDF]
Frontiers in ImmunologyThe Corona Virus Disease (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has quickly spread worldwide and resulted in significant morbidity and mortality.
Qian Weiwei
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NSUN7-mediated m5C methylation of NLRP3 promotes pyroptosis in ovarian granulosa cells in polycystic ovary syndrome [PDF]
Scientific ReportsPyroptosis is a pathogenenic mechanism of polycystic ovary syndrome (PCOS). N5-methylcytosine (m5C) methylation is a RNA modification that affects the progression of diseases. However, its role in PCOS remains not understood.
Tiansong Yang, Yang Tiansong
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NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2-Dependent Stabilisation of SCD1 m5C Methylation. [PDF]
Adv Sci (Weinh)NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Song XX +12 more
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Frontiers in Molecular Biosciences, 2020 5-Methylcytosine (m5C) is a kind of methylation modification that occurs in both DNA and RNA and is present in the highly abundant tRNA and rRNA. It has an important impact on various human diseases including cancer.
Shixin Xiang +2 more
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Frontiers in Cell and Developmental Biology, 2021 PurposeThe m5C RNA methylation regulators are closely related to tumor proliferation, occurrence, and metastasis. This study aimed to investigate the gene expression, clinicopathological characteristics, and prognostic value of m5C regulators in triple ...
Zhidong Huang, Helin Wang, Debo Chen
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