NSUN2 facilitates tenogenic differentiation of rat tendon-derived stem cells via m5C methylation of KLF2 [PDF]
Regenerative TherapyIntroduction: Tendon-derived stem cells (TDSCs) play a critical role in tendon repair. N5-methylcytosine (m5C) is a key regulator of cellular processes such as differentiation. This study aimed to investigate the impact of m5C on TDSC differentiation and
Wei Lin +4 more
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NSUN7-mediated m5C methylation of NLRP3 promotes pyroptosis in ovarian granulosa cells in polycystic ovary syndrome [PDF]
Scientific ReportsPyroptosis is a pathogenenic mechanism of polycystic ovary syndrome (PCOS). N5-methylcytosine (m5C) methylation is a RNA modification that affects the progression of diseases. However, its role in PCOS remains not understood.
Tiansong Yang
exaly +3 more sources
RNA m5C methylation in cancer: mechanisms and biological impact [PDF]
OncogenesisRNA modification, a prominent epigenetic mechanism, has been implicated in regulating RNA function, stability, processing, and interactions, including pseudouridylation, acetylation, and methylation. Recent evidence highlights that 5-methylcytosine (m5C)
Zhenyu Guan +3 more
doaj +2 more sources
Recent research advances in RNA m5C methylation modification in liver diseases [PDF]
Frontiers in Molecular BiosciencesRNA m5C methylation refers to the process wherein the 5th carbon atom of cytosine in RNA molecules is methylated by the action of methyltransferase, thus forming 5-methylcytosine (m5C).
Wenjuan Chen +11 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2021 PurposeThe m5C RNA methylation regulators are closely related to tumor proliferation, occurrence, and metastasis. This study aimed to investigate the gene expression, clinicopathological characteristics, and prognostic value of m5C regulators in triple ...
Debo Chen, Zhidong Huang, Xianqiang Du
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m5C Methylation of mRNA: Still More Questions Than Answers [PDF]
CellsmRNA plays a pivotal role in cellular processes of genetic information transfer, and post-transcriptional modifications of its nucleotides enable regulation of these processes with each particular mRNA. m5C methylation is a specific RNA modification that
Elena S. Babaylova +2 more
doaj +2 more sources
RNA m5C methylation: a potential modulator of innate immune pathways in hepatocellular carcinoma [PDF]
Frontiers in ImmunologyRNA 5-methylcytosine (m5C) methylation plays a crucial role in hepatocellular carcinoma (HCC). As reported, aberrant m5C methylation is closely associated with the progression, therapeutic efficacy, and prognosis of HCC.
Sun Meng +5 more
doaj +2 more sources
RNA m5C methylation modification: a potential therapeutic target for SARS-CoV-2-associated myocarditis [PDF]
Frontiers in ImmunologyThe Corona Virus Disease (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has quickly spread worldwide and resulted in significant morbidity and mortality.
Yan Xiong +5 more
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The Role of NSUN Family Genes in m5C Methylation and Diseases [PDF]
Biomedicines5-Methylcytosine (m5C) methylation is a widely present nucleic acid modification in various RNAs and is a reversible epigenetic modification that affects RNA stability, nuclear export, and translation processes.
Tao Jiang +3 more
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NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation [PDF]
Breast Cancer ResearchBackground RNA m5C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, the precise impact of NSUN2-mediated m5C
Xuran Zhang +16 more
doaj +2 more sources