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The multifaceted role of m5C RNA methylation in digestive system tumorigenesis
Frontiers in Cell and Developmental Biology5-Methylcytosine (m5C) is a widespread RNA methylation modification, wherein a methyl group is enzymatically transferred to specific RNA sites by methyltransferases, such as the NSUN family and DNMT2.
Hu Xinjun, Gu Xinyu, Liu Yafeng
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m5C RNA methylation: a potential mechanism for infectious Alzheimer’s disease
Frontiers in Cell and Developmental BiologyAlzheimer’s disease (AD) is a neurodegenerative disorder caused by a variety of factors, including age, genetic susceptibility, cardiovascular disease, traumatic brain injury, and environmental factors.
Qian Weiwei, He Zhenyan, Weiwei Qian
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Frontiers in Plant ScienceCytosine-5 methylation (m5C) is a crucial epitranscriptomic mark in eukaryotes that modulates RNA stability and gene expression. While the roles of m5C are partially understood in model plants, its function in horticultural crops under biotic stress ...
Jingguang Yang, Yubing Jiao, An Dong
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Frontiers in Immunology, 2022 Background5-Methylcytidine (m5C) methylation is an emerging epigenetic modification in recent years, which is associated with the development and progression of various cancers. However, the prognostic value of m5C regulatory genes and the correlation between m5C methylation and the tumor microenvironment (TME) in prostate cancer remain unknown ...
Wang Jiangyi, Liu Yushan, Zhan Ming
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Frontiers in Molecular Biosciences, 2020 5-Methylcytosine (m5C) is a kind of methylation modification that occurs in both DNA and RNA and is present in the highly abundant tRNA and rRNA. It has an important impact on various human diseases including cancer.
Mingxing Li, Yueshui Zhao
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RNA m5C methylation in cancer: mechanisms and biological impact
OncogenesisRNA modification, a prominent epigenetic mechanism, has been implicated in regulating RNA function, stability, processing, and interactions, including pseudouridylation, acetylation, and methylation. Recent evidence highlights that 5-methylcytosine (m5C)
Zhenyu Guan +3 more
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Frontiers in Cell and Developmental Biology, 2021 PurposeThe m5C RNA methylation regulators are closely related to tumor proliferation, occurrence, and metastasis. This study aimed to investigate the gene expression, clinicopathological characteristics, and prognostic value of m5C regulators in triple ...
Helin Wang, Debo Chen, Zhidong Huang
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RNA m5C methylation: a potential modulator of innate immune pathways in hepatocellular carcinoma
Frontiers in ImmunologyRNA 5-methylcytosine (m5C) methylation plays a crucial role in hepatocellular carcinoma (HCC). As reported, aberrant m5C methylation is closely associated with the progression, therapeutic efficacy, and prognosis of HCC.
Sun Meng +5 more
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m5C RNA methylation in cancer: from biological mechanism to clinical perspectives
European Journal of Medical ResearchCancer remains a significant global health threat, characterized by high morbidity and mortality rates. Despite advancements, numerous challenges persist in cancer treatment, underscoring the urgent need for novel therapeutic strategies.
Fang Yuan +5 more
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Recent insights into RNA m5C methylation modification in hepatocellular carcinoma
Biochimica Et Biophysica Acta: Reviews on CancerRNA 5-methylcytosine (m5C) methylation involves the addition of a methyl (-CH3) group to the cytosine (C) base within an RNA molecule, forming the m5C modification. m5C plays a role in numerous essential biological processes, including the regulation of RNA stability, nuclear export, and protein translation.
Mingyu He
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