Results 11 to 20 of about 5,629 (182)

Research progress on m5C methylation and its prospects in tumor immunotherapy

口腔疾病防治
Epigenetic modification plays an important role in the biological regulatory process of eukaryotic cells. Tumor immunotherapy is an important means and clinical strategy for the treatment of some cancers.
LU Yunyang, DU Weidong, YU Dongsheng
doaj   +3 more sources

NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m5C methylation [PDF]

Journal of Translational Medicine
Background Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and retinal traction, thereby ...
Runze Wang, Wei Xue, Feifei Kan, Huiying Zhang, Di Wang, Lei Wang, Jianwen Wang   +6 more
doaj   +3 more sources

Comprehensive Analysis of m5C Methylation Regulatory Genes and Tumor Microenvironment in Prostate Cancer [PDF]

Frontiers in Immunology, 2022
Background5-Methylcytidine (m5C) methylation is an emerging epigenetic modification in recent years, which is associated with the development and progression of various cancers. However, the prognostic value of m5C regulatory genes and the correlation between m5C methylation and the tumor microenvironment (TME) in prostate cancer remain unknown ...
Guopeng Yu, Jiahao Bao, Shangqing Song   +2 more
exaly   +5 more sources

Comprehensive Analysis of m5C RNA Methylation Regulator Genes in Clear Cell Renal Cell Carcinoma

International Journal of Genomics, 2021
Background. Recent research found that N5-methylcytosine (m5C) was involved in the development and occurrence of numerous cancers. However, the function and mechanism of m5C RNA methylation regulators in clear cell renal cell carcinoma (ccRCC) remains ...
Jiajin Wu, Chao Hou, Yuhao Wang, Zhongyuan Wang, Pu Li, Zengjun Wang   +5 more
doaj   +2 more sources

An m5C methylation regulator-associated signature predicts prognosis and therapy response in pancreatic cancer. [PDF]

Front Cell Dev Biol, 2022
Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive digestive malignancy due to frequent late-stage diagnosis, rapid progression and resistance to therapy. With increasing PDAC incidence worldwide, there is an urgent need for new prognostic biomarkers and therapy targets.
Yun D, Yang Z, Zhang S, Yang H, Liu D, Grützmann R, Pilarsky C, Britzen-Laurent N.   +7 more
europepmc   +5 more sources

Protocol for profiling RNA m⁵C methylation at base resolution using m⁵C-TAC-seq. [PDF]

STAR Protoc
RNA 5-methylcytosine (m5C) is a widespread modification and plays a crucial role in gene expression regulation. Here, we present a protocol for transcriptome-wide m5C methylome profiling at base resolution using bisulfite-free m5C detection strategy enabled by ten-eleven translocation (TET)-assisted chemical labeling sequencing (m5C-TAC-seq). We detail
Zhang X, Lu L, Yi C, Li X.
europepmc   +5 more sources

Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing [PDF]

International Journal of Genomics, 2018
Background. Compared with the well-studied 5-methylcytosine (m5C) in DNA, the role and topology of epitranscriptome m5C remain insufficiently characterized. Results.
Zhen Wei, Subbarayalu Panneerdoss, Santosh Timilsina, Jingting Zhu, Tabrez A. Mohammad, Zhi-Liang Lu, João Pedro de Magalhães, Yidong Chen, Rong Rong, Yufei Huang, Manjeet K. Rao, Jia Meng   +11 more
doaj   +2 more sources

5-Methylcytosine (m5C) Modification Patterns and Tumor Immune Infiltration Characteristics in Clear Cell Renal Cell Carcinoma

Current Oncology, 2022
Recently, studies have revealed the prognostic value of 5-methylcytosine (m5C) in clear cell renal cell carcinoma (ccRCC). However, the role of m5C methylation in ccRCC immune infiltration and the immunotherapeutic response remains unknown.
Can Chen, Lin-Yuan Chen, Jie-Xin Zhang, Hua-Guo Xu   +3 more
doaj   +2 more sources

m5C RNA methylation in cancer: from biological mechanism to clinical perspectives

European Journal of Medical Research
Cancer remains a significant global health threat, characterized by high morbidity and mortality rates. Despite advancements, numerous challenges persist in cancer treatment, underscoring the urgent need for novel therapeutic strategies.
Fang Yuan, Yuxuan Xia, Zhen Huang, Huihui Gao, Yuqi Bian, Xiangqin Zhou   +5 more
doaj   +3 more sources

Identification of m1A/m6A/m5C/m7G-related genes and clusters associated with neuropathic pain [PDF]

Frontiers in Neurology
IntroductionRNA methylation modifications, including N1 methyladenosine (m1A), N6-methyladenosine (m6A), 5-methylcytosine (m5C), and 7-methylguanosine (m7G) methylation, have been increasingly implicated in nervous system disorders. The aim of this study
Liangyuan Tan, Liangyuan Tan, Xiaofeng Gan, Dongming Lu, Dongming Lu, Yingye Liang, Yingye Liang, Weiyan Fu, Weiyan Fu, Zhengbao Gan, Zhengbao Gan, Kailong Wang, Kailong Wang, Hongliang Tang, Peipei Yang, Peipei Yang   +15 more
doaj   +2 more sources