The multifaceted role of m5C RNA methylation in digestive system tumorigenesis
Frontiers in Cell and Developmental Biology5-Methylcytosine (m5C) is a widespread RNA methylation modification, wherein a methyl group is enzymatically transferred to specific RNA sites by methyltransferases, such as the NSUN family and DNMT2.
Xinjun Hu, Xinyu Gu, Kaijie Liu
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Comprehensive Analysis of m5C Methylation Regulatory Genes and Tumor Microenvironment in Prostate Cancer [PDF]
Frontiers in Immunology, 2022 Background5-Methylcytidine (m5C) methylation is an emerging epigenetic modification in recent years, which is associated with the development and progression of various cancers. However, the prognostic value of m5C regulatory genes and the correlation between m5C methylation and the tumor microenvironment (TME) in prostate cancer remain unknown ...
Jiangyi Wang, Jiahao Bao, Yushan Liu
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Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing [PDF]
International Journal of Genomics, 2018 Background. Compared with the well-studied 5-methylcytosine (m5C) in DNA, the role and topology of epitranscriptome m5C remain insufficiently characterized. Results.
Zhen Wei +11 more
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Frontiers in Plant ScienceCytosine-5 methylation (m5C) is a crucial epitranscriptomic mark in eukaryotes that modulates RNA stability and gene expression. While the roles of m5C are partially understood in model plants, its function in horticultural crops under biotic stress ...
Yingwen Wang, Dong An, Lili Shen
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Comprehensive Analysis of m5C RNA Methylation Regulator Genes in Clear Cell Renal Cell Carcinoma
International Journal of Genomics, 2021 Background. Recent research found that N5-methylcytosine (m5C) was involved in the development and occurrence of numerous cancers. However, the function and mechanism of m5C RNA methylation regulators in clear cell renal cell carcinoma (ccRCC) remains ...
Jiajin Wu +5 more
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m5C RNA methylation in cancer: from biological mechanism to clinical perspectives
European Journal of Medical ResearchCancer remains a significant global health threat, characterized by high morbidity and mortality rates. Despite advancements, numerous challenges persist in cancer treatment, underscoring the urgent need for novel therapeutic strategies.
Fang Yuan +5 more
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The novel regulatory influence of Argonaute 1 on messenger RNA 5‐methylcytosine modification in Arabidopsis thaliana [PDF]
Plant GenomeAbstract 5‐Methylcytidine (m5C) modifications play a critical role in RNA metabolism. TRM4B (tRNA‐specific methytransferase 4B) is the only known component of the plant m5C machinery that mediates mRNA (messenger RNA) methylation. To date, no regulators governing site‐specific m5C modifications have been identified, apart from several degenerated ...
Feng Z +6 more
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Research progress on m5C methylation and its prospects in tumor immunotherapy
口腔疾病防治Epigenetic modification plays an important role in the biological regulatory process of eukaryotic cells. Tumor immunotherapy is an important means and clinical strategy for the treatment of some cancers.
LU Yunyang, DU Weidong, YU Dongsheng
doaj +2 more sources
NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m5C methylation [PDF]
Journal of Translational MedicineBackground Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and retinal traction, thereby ...
Runze Wang +6 more
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m5C RNA methylation: a potential mechanism for infectious Alzheimer’s disease
Frontiers in Cell and Developmental BiologyAlzheimer’s disease (AD) is a neurodegenerative disorder caused by a variety of factors, including age, genetic susceptibility, cardiovascular disease, traumatic brain injury, and environmental factors.
Sisi Teng +6 more
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