Results 21 to 30 of about 171,203 (189)

Role of m5C methylation in digestive system tumors (Review). [PDF]

Mol Med Rep
Currently, the incidence of digestive system tumors has been increasing annually, thus becoming a prevalent cause of cancer‑related mortalities. Although significant strides have been made in targeting the molecular mechanisms that underpin the development of these tumors, their treatment and prognosis still pose substantial challenges.
Zhang L, Yuan J, Yao S, Wen G, An J, Jin H, Tuo B.   +6 more
europepmc   +3 more sources

RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming. [PDF]

J Cell Mol Med, 2023
AbstractRecently, epigenetics showed essential roles in tumour microenvironment (TME) and immunotherapy response, however, the functions of RNA 5‐methylcytosine (m5C) modification in TME remains unknown. According to 13 m5C regulators, we evaluated 412 BLCA patients from The Cancer Genome Atlas (TCGA) database.
Yan D, Xie Y, Huang L, Zhang Y, Gu R, Xie H, Huang X, Luo H.   +7 more
europepmc   +3 more sources

A CNN based m5c RNA methylation predictor

Scientific Reports, 2023
AbstractPost-transcriptional modifications of RNA play a key role in performing a variety of biological processes, such as stability and immune tolerance, RNA splicing, protein translation and RNA degradation. One of these RNA modifications is m5c which participates in various cellular functions like RNA structural stability and translation efficiency,
Irum Aslam, Sajid Shah, Saima Jabeen, Mohammed ElAffendi, Asmaa A. Abdel Latif, Nuhman Ul Haq, Gauhar Ali   +6 more
openaire   +3 more sources

m5C-Atlas: a comprehensive database for decoding and annotating the 5-methylcytosine (m5C) epitranscriptome. [PDF]

, 2021
5-Methylcytosine (m5C) is one of the most prevalent covalent modifications on RNA. It is known to regulate a broad variety of RNA functions, including nuclear export, RNA stability and translation. Here, we present m5C-Atlas, a database for comprehensive
Huang, Daiyun, de Magalhães, João Pedro, Meng, Jia, Ma, Jiongming, Song, Bowen, Rigden, Daniel J, Zhang, Yuxin, Su, Jionglong, Chen, Kunqi, Wei, Zhen, Yuxin Zhang, Jiongming Ma, Kunqi Chen, Jionglong Su, João Pedro de Magalhães, Daniel J Rigden, Bowen Song, Zhen Wei, Daiyun Huang, Jia Meng   +19 more
core   +1 more source

m5C methylation modification may be an accomplice in colorectal cancer escaping from anti-tumor effects of innate immunity-type I/III interferon [PDF]

Frontiers in Immunology
Chao Zhong, Lu Jiang
exaly   +2 more sources

5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of m5C formation catalyzed by RNA methyltransferase

BMC Research Notes, 2022
Objective 5-Methylcytosine (m5C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA m5C has been extensively studied over the past years, the distribution and biological function of RNA m5C still
Junfeng Liu
doaj   +1 more source

Overview of distinct 5-methylcytosine profiles of messenger RNA in normal and knock-down NSUN2 colorectal cancer cells

Frontiers in Genetics, 2023
Background: Colorectal cancer (CRC) is a harmful cancer with high morbidity and poor prognosis. There is growing evidence that RNA methylation is closely related to the occurrence of cancer and its malignant biological behavior.
Yu Lin, Yu Lin, Yu Lin, Zhifang Zhao, Wenqiang Nie, Manting Huang, Jiazhong Cai, Yadong Wang, Hesong Wang, Yongmei Huang, Yang Bai, Yang Bai   +11 more
doaj   +1 more source

Folate regulates RNA m5C modification and translation in neural stem cells

BMC Biology, 2022
Background Folate is an essential B-group vitamin and a key methyl donor with important biological functions including DNA methylation regulation. Normal neurodevelopment and physiology are sensitive to the cellular folate levels.
Xiguang Xu, Zachary Johnson, Amanda Wang, Rachel L. Padget, James W. Smyth, Hehuang Xie   +5 more
doaj   +1 more source

m5C methylation modification guides the prognostic value and immune landscapes in acute myeloid leukemia. [PDF]

Aging (Albany NY), 2023
The development, incidence, and metastasis of tumors are all intimately correlated with 5-methylcytosine (m5C). However, uncertainty surrounds the function of m5C in acute myeloid leukemia (AML). In this study, multicenter AML data were collected and analyzed comprehensively to grasp the gene expression level, clinicopathological characteristics ...
Liu Y, Chen Y, Cai M, Hong Y, Wu X, Li S.   +5 more
europepmc   +3 more sources

An m5C methylation regulator-associated signature predicts prognosis and therapy response in pancreatic cancer. [PDF]

Front Cell Dev Biol, 2022
Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive digestive malignancy due to frequent late-stage diagnosis, rapid progression and resistance to therapy. With increasing PDAC incidence worldwide, there is an urgent need for new prognostic biomarkers and therapy targets.
Yun D, Yang Z, Zhang S, Yang H, Liu D, Grützmann R, Pilarsky C, Britzen-Laurent N.   +7 more
europepmc   +4 more sources