Results 21 to 30 of about 5,629 (182)

The multifaceted role of m5C RNA methylation in digestive system tumorigenesis

Frontiers in Cell and Developmental Biology
5-Methylcytosine (m5C) is a widespread RNA methylation modification, wherein a methyl group is enzymatically transferred to specific RNA sites by methyltransferases, such as the NSUN family and DNMT2.
Xinjun Hu, Yafeng Liu, Shujun Zhang, Kaijie Liu, Xinyu Gu   +4 more
doaj   +3 more sources

Role of m5C methylation in digestive system tumors (Review). [PDF]

Mol Med Rep
Currently, the incidence of digestive system tumors has been increasing annually, thus becoming a prevalent cause of cancer‑related mortalities. Although significant strides have been made in targeting the molecular mechanisms that underpin the development of these tumors, their treatment and prognosis still pose substantial challenges.
Zhang L, Yuan J, Yao S, Wen G, An J, Jin H, Tuo B.   +6 more
europepmc   +3 more sources

RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming. [PDF]

J Cell Mol Med, 2023
AbstractRecently, epigenetics showed essential roles in tumour microenvironment (TME) and immunotherapy response, however, the functions of RNA 5‐methylcytosine (m5C) modification in TME remains unknown. According to 13 m5C regulators, we evaluated 412 BLCA patients from The Cancer Genome Atlas (TCGA) database.
Yan D, Xie Y, Huang L, Zhang Y, Gu R, Xie H, Huang X, Luo H.   +7 more
europepmc   +3 more sources

Deciphering the Divergent Gene Expression Landscapes of m6A/m5C/m1A Methylation Regulators in Hepatocellular Carcinoma Through Single-Cell and Bulk RNA Transcriptomic Analysis

Journal of Hepatocellular Carcinoma, 2023
Hang-Tsung Liu,1,* Cheng-Shyuan Rau,2,* Yueh-Wei Liu,3 Ting-Min Hsieh,1 Chun-Ying Huang,1 Peng-Chen Chien,4 Hui-Ping Lin,4 Chia-Jung Wu,4 Pei-Chin Chuang,5 Ching-Hua Hsieh4 1Department of Trauma Surgery, Kaohsiung Chang Gung Memorial Hospital and
Liu HT, Rau CS, Liu YW, Hsieh TM, Huang CY, Chien PC, Lin HP, Wu CJ, Chuang PC, Hsieh CH   +9 more
doaj   +1 more source

Epitranscriptomic profiling of m5C RNA methylation reveals a dynamic response to TSWV infection in tomato

Frontiers in Plant Science
Cytosine-5 methylation (m5C) is a crucial epitranscriptomic mark in eukaryotes that modulates RNA stability and gene expression. While the roles of m5C are partially understood in model plants, its function in horticultural crops under biotic stress ...
Xinyi Zhao, Yanwei Gong, Yubing Jiao, Wanhong Zhang, Dong An, Yingwen Wang, Binna Lv, Ying Li, Lili Shen, Jinguang Yang   +9 more
doaj   +3 more sources

m5C RNA methylation: a potential mechanism for infectious Alzheimer’s disease

Frontiers in Cell and Developmental Biology
Alzheimer’s disease (AD) is a neurodegenerative disorder caused by a variety of factors, including age, genetic susceptibility, cardiovascular disease, traumatic brain injury, and environmental factors.
Sisi Teng, Cunqiao Han, Jian Zhou, Jian Zhou, Zhenyan He, Weiwei Qian, Weiwei Qian   +6 more
doaj   +3 more sources

m5C methylation modification guides the prognostic value and immune landscapes in acute myeloid leukemia. [PDF]

Aging (Albany NY), 2023
The development, incidence, and metastasis of tumors are all intimately correlated with 5-methylcytosine (m5C). However, uncertainty surrounds the function of m5C in acute myeloid leukemia (AML). In this study, multicenter AML data were collected and analyzed comprehensively to grasp the gene expression level, clinicopathological characteristics ...
Liu Y, Chen Y, Cai M, Hong Y, Wu X, Li S.   +5 more
europepmc   +3 more sources

A CNN based m5c RNA methylation predictor

Scientific Reports, 2023
AbstractPost-transcriptional modifications of RNA play a key role in performing a variety of biological processes, such as stability and immune tolerance, RNA splicing, protein translation and RNA degradation. One of these RNA modifications is m5c which participates in various cellular functions like RNA structural stability and translation efficiency,
Irum Aslam, Sajid Shah, Saima Jabeen, Mohammed ElAffendi, Asmaa A. Abdel Latif, Nuhman Ul Haq, Gauhar Ali   +6 more
openaire   +3 more sources

m5C methylation modification may be an accomplice in colorectal cancer escaping from anti-tumor effects of innate immunity-type I/III interferon [PDF]

Frontiers in Immunology
Chao Zhong, Zhong Chao
exaly   +2 more sources

NOP2-Mediated m5C Methylation Modification of LMNB2 mRNA Facilitates Colorectal Cancer Progression. [PDF]

Cancer Med
Background Colorectal cancer (CRC) is a leading cause of cancer‐related mortality globally, yet current therapies exhibit suboptimal efficacy with limited prognostic improvement.
Bi J, Huang Y, Hu W, Liu Y.
europepmc   +2 more sources