Results 41 to 50 of about 171,203 (189)

5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis

Frontiers in Immunology, 2022
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis.
Haofan Yin, Haofan Yin, Zhijian Huang, Zhijian Huang, Shiqiong Niu, Liang Ming, Hongbo Jiang, Liang Gu, Liang Gu, Weibin Huang, Weibin Huang, Jinye Xie, Yulong He, Yulong He, Changhua Zhang, Changhua Zhang   +15 more
doaj   +1 more source

5-Methylcytosine (m5C) Modification Patterns and Tumor Immune Infiltration Characteristics in Clear Cell Renal Cell Carcinoma

Current Oncology, 2022
Recently, studies have revealed the prognostic value of 5-methylcytosine (m5C) in clear cell renal cell carcinoma (ccRCC). However, the role of m5C methylation in ccRCC immune infiltration and the immunotherapeutic response remains unknown.
Can Chen, Lin-Yuan Chen, Jie-Xin Zhang, Hua-Guo Xu   +3 more
doaj   +1 more source

Protocol for profiling RNA m⁵C methylation at base resolution using m⁵C-TAC-seq. [PDF]

STAR Protoc
RNA 5-methylcytosine (m5C) is a widespread modification and plays a crucial role in gene expression regulation. Here, we present a protocol for transcriptome-wide m5C methylome profiling at base resolution using bisulfite-free m5C detection strategy enabled by ten-eleven translocation (TET)-assisted chemical labeling sequencing (m5C-TAC-seq). We detail
Zhang X, Lu L, Yi C, Li X.
europepmc   +4 more sources

Identification of M5c regulator-medicated methylation modification patterns for prognosis and immune microenvironment in glioma

Aging, 2023
Glioma is a common intracranial tumor and is generally associated with poor prognosis. Recently, numerous studies illustrated the importance of 5-methylcytosine (m5C) RNA modification to tumorigenesis. However, the prognostic value and immune correlation of m5C in glioma remain unclear.
Xiao, Zhenyong, Li, Jinwei, Liang, Cong, Liu, Yamei, Zhang, Yuxiu, Zhang, Yuxia, Liu, Quan, Yan, Xianlei   +7 more
openaire   +2 more sources

Immune Infiltrates of m5C RNA Methylation-Related LncRNAs in Uterine Corpus Endometrial Carcinoma

Journal of Oncology, 2022
Aberrant 5-methylcytidine (m5C) modification plays an essential role in the progression of different cancers. More and more researchers are focusing on developing a lncRNA-based risk model to assess the clinical prognosis of cancer patients. However, the impact of m5C-related lncRNAs on the prognosis of patients with uterine corpus endometrial ...
Wen-Xiu Gu, Yan Chen, Wei Wang
openaire   +2 more sources

RNA 5-Methylcytosine Regulators Contribute to Metabolism Heterogeneity and Predict Prognosis in Ovarian Cancer

Frontiers in Cell and Developmental Biology, 2022
5-Methylcytosine (m5C) is an abundant and highly conserved modification in RNAs. The dysregulation of RNA m5C methylation has been reported in cancers, but the regulatory network in ovarian cancer of RNA m5C methylation-related genes and its implication ...
Jie Xu, Xiaoyi Liu, Yanjie Chen, Yuya Wang, Tao Liu, Ping Yi   +5 more
doaj   +1 more source

Distinct 5-methylcytosine profiles in poly(A) RNA from mouse embryonic stem cells and brain [PDF]

, 2017
Background Recent work has identified and mapped a range of posttranscriptional modifications in mRNA, including methylation of the N6 and N1 positions in adenine, pseudouridylation, and methylation of carbon 5 in cytosine (m5C ...
Wille, Alexandra, Xi-Yu Jia, Trixl, Lukas, Thomas Amort, Lusser, Alexandra, Lukas Trixl, Khokhlova-Cubberley, Daria, Alexandra Wille, Rieder, Dietmar, Amort, Thomas, Riml, Christian, Jia, Xi-Yu, Dietmar Rieder, Daria Khokhlova-Cubberley, Alexandra Lusser, Christian Riml, Ronald Micura, Micura, Ronald   +17 more
core   +1 more source

Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers

Frontiers in Oncology
The 5-methylcytosine (m5C) modification is a crucial epigenetic RNA modification, which is involved in the post-transcriptional regulation of genes. It plays an important role in various biological processes, including cell metabolism, growth, apoptosis,
Tingting Zhao, Zhe Zhang, Zhuo Chen, Guozheng Xu, Yongxi Wang, Fang Wang   +5 more
doaj   +1 more source

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Dominguez Salas, Paula, Dominguez-Salas, P, Prentice, AM, Sophie E. Moore, Cox, SE, Dominguez-Salas, Paula, Prentice, Andrew M, Hennig, Branwen J, Paula Dominguez-Salas, Andrew M. Prentice, Moore, SE, Moore, Sophie E, Hennig, BJ, Cox, Sharon E, Prentice, Andrew M., Moore, Sophie E., Hennig, Branwen J., Branwen J. Hennig, Sharon E. Cox, Cox, Sharon E.   +19 more
core   +1 more source

Novel insights into the role of 5-Methylcytosine RNA methylation in human abdominal aortic aneurysm

Frontiers in Bioscience-Landmark, 2021
Background: It remains largely unclear about the function of 5-methylcytosine (m5C) RNA modification in the context of abdominal aortic aneurysm (AAA).
Yuchen He, Hao Zhang, Fanxing Yin, Panpan Guo, Shiyue Wang, Yihao Wu, Shijie Xin, Yanshuo Han, Jian Zhang   +8 more
doaj   +1 more source