Results 51 to 60 of about 171,203 (189)
Frontiers in Cell and Developmental Biology, 2021 RNA methylation is considered a significant epigenetic modification, a process that does not alter gene sequence but may play a necessary role in multiple biological processes, such as gene expression, genome editing, and cellular differentiation.
Yating Xu +24 more
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Cancer Management and Research, 2020 Yuting He,1,2,* Qingmiao Shi,1,2,* Yize Zhang,1,2,* Xin Yuan,1,2 Zujiang Yu1,2 1Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, People’s Republic of China ...
He Y, Shi Q, Zhang Y, Yuan X, Yu Z
doaj
Scientific Reports, 2023 DNA methylation is an epigenetic modification detected in both prokaryotic and eukaryotic genomic DNAs. In bacteria, the importance of 5-methylcytosine (m5C) in gene expression has been less investigated than in eukaryotic systems.
Annalisa Pisciotta +5 more
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Advanced Science, EarlyView.This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao +8 more
wiley +1 more source
Advanced Science, EarlyView.NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu +10 more
wiley +1 more source
NSUN6, a Gene Related With m5c Methylation, May Serve as a Biomarker for Pan-cancer [PDF]
, 2022 Abstract Background: 5-methylcytosine (m5c) is a common chemical alteration in DNA and RNA, however unlike DNA modifying enzymes, the methyl-transferases that make m5c changes in RNA are little understood. The putative RNA methyltransferase NSUN6 is a member of the Nol1/Nop2/SUN domain (NSUN) protein family, but its function in most ...
Baishun Ma, Pu Wang
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Presentation1_Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning.PDF
, 2018 The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization
Jie Song (60883) +5 more
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The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis [PDF]
, 2015 A critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA methylation. The catalytically inactive adaptor Dnmt3L is essential to ensuring this occurs correctly, but the mechanism by which it functions is unclear.
Robert J. Schmitz +26 more
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The Emerging Roles of Cytosine-5 Methylation in mRNAs [PDF]
, 2021 Recent studies have unequivocally confirmed the presence of 5-methylcytosine (m5C) in mammalian mRNAs while indicating significant functional roles for this internal base modification type.
Hussain, Shobbir, Shobbir Hussain
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Frontiers in Cell and Developmental Biology, 2020 Epigenetic processes including RNA methylation, post-translational modifications, and non-coding RNA expression have been associated with the heritable risks of systemic lupus erythematosus (SLE).
Gangqiang Guo +10 more
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