Results 51 to 60 of about 5,629 (182)

RNA 5-Methylcytosine Regulators Contribute to Metabolism Heterogeneity and Predict Prognosis in Ovarian Cancer

Frontiers in Cell and Developmental Biology, 2022
5-Methylcytosine (m5C) is an abundant and highly conserved modification in RNAs. The dysregulation of RNA m5C methylation has been reported in cancers, but the regulatory network in ovarian cancer of RNA m5C methylation-related genes and its implication ...
Jie Xu, Xiaoyi Liu, Yanjie Chen, Yuya Wang, Tao Liu, Ping Yi   +5 more
doaj   +1 more source

Transcriptome-Wide 5-Methylcytosine Functional Profiling of Long Non-Coding RNA in Hepatocellular Carcinoma

Cancer Management and Research, 2020
Yuting He,1,2,* Qingmiao Shi,1,2,* Yize Zhang,1,2,* Xin Yuan,1,2 Zujiang Yu1,2 1Gene Hospital of Henan Province, Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, People’s Republic of China ...
He Y, Shi Q, Zhang Y, Yuan X, Yu Z
doaj  

Disease Activity-Associated Alteration of mRNA m5 C Methylation in CD4+ T Cells of Systemic Lupus Erythematosus

Frontiers in Cell and Developmental Biology, 2020
Epigenetic processes including RNA methylation, post-translational modifications, and non-coding RNA expression have been associated with the heritable risks of systemic lupus erythematosus (SLE).
Gangqiang Guo, Gangqiang Guo, Huijing Wang, Xinyu Shi, Lele Ye, Lele Ye, Kejing Yan, Zhiyuan Chen, Huidi Zhang, Zibing Jin, Xiangyang Xue   +10 more
doaj   +1 more source

The DNA cytosine methylome revealed two methylation motifs in the upstream regions of genes related to morphological and physiological differentiation in Streptomyces coelicolor A(3)2 M145

Scientific Reports, 2023
DNA methylation is an epigenetic modification detected in both prokaryotic and eukaryotic genomic DNAs. In bacteria, the importance of 5-methylcytosine (m5C) in gene expression has been less investigated than in eukaryotic systems.
Annalisa Pisciotta, Alessia Maria Sampino, Alessandro Presentato, Marco Galardini, Angel Manteca, Rosa Alduina   +5 more
doaj   +1 more source

Additional file 1 of Folate regulates RNA m5C modification and translation in neural stem cells

, 2022
Additional file 1: Figure S1. Quality control of total mRNA-seq datasets. (a, b, c) Scatter plot showing the Pearson correlation between two biological replicates in total mRNA-seq datasets in NSCs.
Zachary Johnson (571094), Xiguang Xu (4989533), James W. Smyth (9977294), Hehuang Xie (14176515), Rachel L. Padget (14176512), Amanda Wang (673947)   +5 more
core   +1 more source

Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers

Frontiers in Oncology
The 5-methylcytosine (m5C) modification is a crucial epigenetic RNA modification, which is involved in the post-transcriptional regulation of genes. It plays an important role in various biological processes, including cell metabolism, growth, apoptosis,
Tingting Zhao, Zhe Zhang, Zhuo Chen, Guozheng Xu, Yongxi Wang, Fang Wang   +5 more
doaj   +1 more source

Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine

Frontiers in Cell and Developmental Biology, 2021
RNA methylation is considered a significant epigenetic modification, a process that does not alter gene sequence but may play a necessary role in multiple biological processes, such as gene expression, genome editing, and cellular differentiation.
Yating Xu, Yating Xu, Yating Xu, Yating Xu, Menggang Zhang, Menggang Zhang, Menggang Zhang, Menggang Zhang, Qiyao Zhang, Qiyao Zhang, Qiyao Zhang, Qiyao Zhang, Xiao Yu, Xiao Yu, Xiao Yu, Xiao Yu, Zongzong Sun, Yuting He, Yuting He, Yuting He, Yuting He, Wenzhi Guo, Wenzhi Guo, Wenzhi Guo, Wenzhi Guo   +24 more
doaj   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Image_1_5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis.tif

, 2022
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis.
Shiqiong Niu (13835683), Jinye Xie (11504809), Zhijian Huang (1649578), Liang Gu (573034), Liang Ming (280713), Haofan Yin (11504815), Hongbo Jiang (501149), Weibin Huang (9157199), Yulong He (3452147), Changhua Zhang (157463)   +9 more
core   +1 more source