Results 71 to 80 of about 5,629 (182)

NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation

Breast Cancer Research
Background RNA m5C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, the precise impact of NSUN2-mediated m5C
Xuran Zhang, Ke An, Xin Ge, Yuanyuan Sun, Jingyao Wei, Weihong Ren, Han Wang, Yueqin Wang, Yue Du, Lulu He, Ouwen Li, Shaoxuan Zhou, Yong Shi, Tong Ren, Yun-gui Yang, Quancheng Kan, Xin Tian   +16 more
doaj   +1 more source

RNA 5-Methylcytosine Modification in Myocardial Fibrosis

Reviews in Cardiovascular Medicine
Myocardial fibrosis represents a common pathological hallmark of various cardiovascular diseases progressing to heart failure, with the immunoinflammatory response playing a pivotal role in the pathogenesis of myocardial fibrosis.
Bohan Li, Yan Hao, Wendan Tian, Wei Liu
doaj   +1 more source

Image_4_5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis.tif

, 2022
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis.
Shiqiong Niu (13835683), Jinye Xie (11504809), Zhijian Huang (1649578), Liang Gu (573034), Liang Ming (280713), Haofan Yin (11504815), Hongbo Jiang (501149), Weibin Huang (9157199), Yulong He (3452147), Changhua Zhang (157463)   +9 more
core   +1 more source

Developmental mRNA m5C landscape and regulatory innovations of massive m5C modification of maternal mRNAs in animals

Nature Communications, 2022
mRNAs are known to be decorated with m5C at a low-to-medium level. Here, the authors generate atlases of mRNA m5C during animal development in 6 species and identify convergent and unexpected massive methylation of maternal mRNAs by NSUN2 and NSUN6.
Jianheng Liu, Tao Huang, Wanying Chen, Chenhui Ding, Tianxuan Zhao, Xueni Zhao, Bing Cai, Yusen Zhang, Song Li, Ling Zhang, Maoguang Xue, Xiuju He, Wanzhong Ge, Canquan Zhou, Yanwen Xu, Rui Zhang   +15 more
doaj   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, Volume 65, Issue 23, 1 June 2026.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Image_3_5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis.tif

, 2022
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis.
Shiqiong Niu (13835683), Jinye Xie (11504809), Zhijian Huang (1649578), Liang Gu (573034), Liang Ming (280713), Haofan Yin (11504815), Hongbo Jiang (501149), Weibin Huang (9157199), Yulong He (3452147), Changhua Zhang (157463)   +9 more
core   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, Volume 73, Issue 3, Page 1137-1150, June 2026.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Distinct 5-methylcytosine profiles of LncRNA in breast cancer brain metastasis

BMC Cancer
Background Recent studies have identified a complex relationship between methylation patterns and the development of various cancers. Breast cancer (BC) is the second leading cause of cancer mortality among women.
Song Wang, Jianran Guo, Xinmiao Xian, Min Li, Anqi Zhang, Yujiao Liu, Yifei Zhang, Shen Chen, Guohao Gu, Xuehua Zhang, Dong Yan, Meng An, Li Pan, Bo Fu   +13 more
doaj   +1 more source

ETV4 Improves Cerebral Ischemia‐Reperfusion Injury by Restraining YBX1‐GPX4‐Ferroptosis Cascades

Brain and Behavior, Volume 16, Issue 6, June 2026.
ABSTRACT Background Cerebral ischemia‐reperfusion injury (CIRI) is a critical pathological process following ischemic stroke, with ferroptosis being increasingly recognized as a key contributor to neuronal damage. However, the regulatory mechanisms, particularly the role of specific transcription factors like E26 transformation‐specific variant 4 (ETV4)
Qian Xu, Faming Deng, Dan Yu
wiley   +1 more source

DataSheet_1_Distinct Roles of m5C RNA Methyltransferase NSUN2 in Major Gynecologic Cancers.pdf

, 2022
RNA methylation has recently emerged as an important category of epigenetic modifications, which plays diverse physiopathological roles in various cancers.
Yasen Maimaitiyiming (1637338), Fenfen Wang (690916), Shizhen Shen (12135822), Chih-Hung Hsu (171225), Lingfang Wang (1588774), Yingfeng Su (12135816), Siqi Yang (1678081), Shitong Lin (8539239), Guankai Zhan (12135825), Zhangjin Shen (12135819), Jian Zhang (1682), Xiaodong Cheng (8947)   +11 more
core   +1 more source