Results 91 to 100 of about 171,203 (189)

Comprehensive Analysis of Differentially Expressed Profiles of mRNA 5-Methylcytosine Modification in Metabolic Dysfunction-Associated Steatotic Liver Disease

Current Issues in Molecular Biology
RNA methylation plays a critical role in regulating all aspects of RNA function, which are implicated in the pathogenesis of various human diseases.
Yueying Yang, E Wang, Bing Zhou, Yan Lu, Xiaoying Ding, Yao Li   +5 more
doaj   +1 more source

Polyphenism Through RNA Chemical Modifications

Molecular Ecology, Volume 35, Issue 19, October 2026.
ABSTRACT Polyphenism, the capacity of a single genotype to produce discrete phenotypes in response to environmental cues, has long served as a model for understanding developmental plasticity. While classical studies have highlighted hormonal signalling and transcription‐factor‐driven gene regulatory networks that mediate these environmentally induced ...
Ralf Schneider, Ehsan Pashay Ahi
wiley   +1 more source

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation [PDF]

, 2011
Background: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with ...
Kreth Simone, Friedrich W. Kreth, Hans A Kretzschmar, Lutz Juergen, Ludwig C. Hinske, Friedrich W Kreth, Ledderose Carola, Kretzschmar, Hans A., Kreth, Friedrich-Wilhelm, Juergen Lutz, Eigenbrod, Sabina, Kreth, Simone, Tonn, Joerg C., Thon Niklas, Thon, Niklas, Eigenbrod Sabina, Joerg C Tonn, Hinske, Ludwig C., Egensperger Rupert, Kretzschmar Hans A., Carola Ledderose, Rupert Egensperger, Kreth Friedrich W., Joerg C. Tonn, Lutz, Juergen, Niklas Thon, Hans A. Kretzschmar, Kreth, Friedrich W., Egensperger, Rupert, Hinske Ludwig C., Hinske, Ludwig Christian, Ludwig C Hinske, Sabina Eigenbrod, Tonn Joerg C., Ledderose, Carola, Simone Kreth   +35 more
core   +1 more source

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

eLife
5-Methylcytosine (m5C) is one of the posttranscriptional modifications in mRNA and is involved in the pathogenesis of various diseases. However, the capacity of existing assays for accurately and comprehensively transcriptome-wide m5C mapping still needs
Jiale Zhou, Ding Zhao, Jinze Li, Deqiang Kong, Xiangrui Li, Renquan Zhang, Yuru Liang, Xun Gao, Yuqiang Qian, Di Wang, Jiahui Chen, Liangxue Lai, Yang Han, Zhanjun Li   +13 more
doaj   +1 more source

Turnover and function of DNA methylation at transcription factor binding sites [PDF]

, 2014
Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
core   +1 more source

Detection, molecular function and mechanisms of m5C in cancer

Clinical and Translational Medicine
Interest in RNA posttranscriptional modifications, particularly 5‐methylcytosine (m5C), has surged in recent years. Studies have shown that m5C plays a key role in cellular processes and is closely linked to tumourigenesis.
Linhui Zhang, Yuelong Li, Liqing Li, Fei Yao, Maoping Cai, Dingwei Ye, Yuanyuan Qu   +6 more
doaj   +1 more source

Identification of m1A/m6A/m5C/m7G-related genes and clusters associated with neuropathic pain

Frontiers in Neurology
IntroductionRNA methylation modifications, including N1 methyladenosine (m1A), N6-methyladenosine (m6A), 5-methylcytosine (m5C), and 7-methylguanosine (m7G) methylation, have been increasingly implicated in nervous system disorders. The aim of this study
Liangyuan Tan, Liangyuan Tan, Xiaofeng Gan, Dongming Lu, Dongming Lu, Yingye Liang, Yingye Liang, Weiyan Fu, Weiyan Fu, Zhengbao Gan, Zhengbao Gan, Kailong Wang, Kailong Wang, Hongliang Tang, Peipei Yang, Peipei Yang   +15 more
doaj   +1 more source

Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation. [PDF]

, 2019
The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m5C) however, it is largely unknown how it recruits or repels RNA-binding proteins.
Selmi, Tommaso, Michlewski, Gracjan, Roy Choudhury, Nila, Bornelöv, Susanne, Rappsilber, Juri, Dietmann, Sabine, Frye, Michaela, Sajini, Abdulrahim A, Wagner, Rebecca E., Spanos, Christos, Choudhury N. R., Sajini A. A., Wagner R. E., Dietmann S., Michlewski G., Spanos C., Rappsilber J., Selmi T., Frye M., Bornelov S.   +19 more
core   +3 more sources

Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer

Biomarker Research, 2020
As an important posttranscriptional modification of RNA, 5-methylcytosine (m5C) has attracted increasing interest recently, with accumulating evidence suggesting the involvement of RNA m5C modification in multiple cellular processes as well as ...
Chen Xue, Yalei Zhao, Lanjuan Li
doaj   +1 more source

How Epitranscriptomic Machinery Senses Environmental Cues

Advanced Biology, Volume 10, Issue 9, September 2026.
Exogenous exposures, microenvironmental signals, and intracellular metabolic or redox states can alter RNA‐modification machinery through catalytic chemistry, signaling‐dependent PTMs, compartmental redistribution, or changes in abundance and composition.
Shayan Jalali, Ehsan Pashay Ahi
wiley   +1 more source