Results 81 to 90 of about 5,629 (182)

Cross-lineage 5-methylcytosine methylome profiling reveals methylated divergence among Toxoplasma gondii tachyzoites of the three major clonal lineages

Infectious Diseases of Poverty
Background Toxoplasma gondii is a globally widespread zoonotic parasite, infecting nearly one-third of the human population, often leading to chronic, latent infections.
Xiao-Nan Zheng, Hong-Yu Song, Hany M. Elsheikha, Chen-Ran Tian, Xing Tian, Qing Liu, Wen-Bin Zheng, Xing-Quan Zhu   +7 more
doaj   +1 more source

TRMT10C promotes mitochondrial fission through transferrin receptor m1A methylation modification and aggravates the progression of atrial fibrillation

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
TRMT10C promotes mitochondrial dynamics imbalance (excessive fission) by regulating TFRC m1A methylation modification, induces myocardial fibrosis, and exacerbates the progression of AF. Abstract Atrial fibrillation (AF) is a common cardiac arrhythmia often accompanied by structural remodeling of the atria, particularly fibrosis, and disruption of ...
Nijina Li, Hao Zhang
wiley   +1 more source

m5C regulator-mediated methylation modification phenotypes characterized by distinct tumor microenvironment immune heterogenicity in colorectal cancer

, 2023
The RNA 5-methylcytosine (m5C) modification has been demonstrated to be an important epigenetic regulator and to impact colorectal cancer (CRC) progression.
Yilin Lin, Shaoqin Chen, Ji Gao, Suyong Lin, Quanfa Li, Zhihua Chen   +5 more
core   +1 more source

Epigenetic Perspectives on Maternal Gut Microbiota's Impact on Embryonic and Fetal Development

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how maternal health and nutrition shape gut microbiota via epigenetics to regulate embryonic development. It highlights microbiota‐embryo interactions, disruption by prenatal chemical exposures, and personalized nutrition for disease prevention, offering novel insights and therapeutic targets.
Shoulong Xu, Yanjiao Huang, Chenyue Hu, Wenli Ding, Zhenwei Pu, Qiang Li, Zhiliang Xu   +6 more
wiley   +1 more source

Comprehensive Analysis of Differentially Expressed Profiles of mRNA 5-Methylcytosine Modification in Metabolic Dysfunction-Associated Steatotic Liver Disease

Current Issues in Molecular Biology
RNA methylation plays a critical role in regulating all aspects of RNA function, which are implicated in the pathogenesis of various human diseases.
Yueying Yang, E Wang, Bing Zhou, Yan Lu, Xiaoying Ding, Yao Li   +5 more
doaj   +1 more source

Solanesol Alleviates Perfluoroheptanoic Acid‐Induced Premature Senescence in Human Skin Fibroblasts via RNA Methylation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Perfluoroheptanoic acid (PFHpA) induces premature senescence in normal human skin fibroblasts (HSFs), as characterized by decreased cell viability, increased SA‐β‐gal staining, impaired wound healing, cell cycle dysregulation, elevated ROS levels, and upregulated SASP mRNA expression.
Jiaqi Fu, Tingting Huang, Guisong Li, Xinyu Zhang, Luyi Tan, Chenyu Zhu, Wenji Zhang, Wenjuan Zhang   +7 more
wiley   +1 more source

DataSheet_1_Developing an m5C regulator–mediated RNA methylation modification signature to predict prognosis and immunotherapy efficacy in rectal cancer.docx

, 2023
BackgroundCurrently, a very small number of patients with colorectal cancer (CRC) respond to immune checkpoint inhibitor (ICI) treatment. Therefore, there is an urgent need to investigate effective biomarkers to determine the responsiveness to ICI ...
Rixin Zhang (7153976), Weiqi Wang (516299), Mingxuan Zhou (12692474), Jinbao Zong (12692471), Wenqiang Gan (9737849), Zifan Zeng (6040601), Fang Zhang (197215), Min Yang (146229), Silin Lv (9737852), Zheng Yan (194231), Yufang Hou (9737855), Tiegang Li (339041)   +11 more
core   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

eLife
5-Methylcytosine (m5C) is one of the posttranscriptional modifications in mRNA and is involved in the pathogenesis of various diseases. However, the capacity of existing assays for accurately and comprehensively transcriptome-wide m5C mapping still needs
Jiale Zhou, Ding Zhao, Jinze Li, Deqiang Kong, Xiangrui Li, Renquan Zhang, Yuru Liang, Xun Gao, Yuqiang Qian, Di Wang, Jiahui Chen, Liangxue Lai, Yang Han, Zhanjun Li   +13 more
doaj   +1 more source

Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer

Biomarker Research, 2020
As an important posttranscriptional modification of RNA, 5-methylcytosine (m5C) has attracted increasing interest recently, with accumulating evidence suggesting the involvement of RNA m5C modification in multiple cellular processes as well as ...
Chen Xue, Yalei Zhao, Lanjuan Li
doaj   +1 more source