Results 1 to 10 of about 20,996,854 (289)

Function and Detection of 5-Methylcytosine in eukaryotic RNA

Epigenomics, 2010
Modified nucleosides play an important role in RNA function and have been identified in multiple RNA types, including tRNAs, rRNAs, mRNAs and small regulatory RNAs. Among these, 5-methylcytosine (m(5)C) has been detected in rRNAs and tRNAs, and early reports suggested its presence in mRNAs.
Squires, Jeffrey, Preiss, Thomas
openaire   +3 more sources

Tet proteins: on track towards DNA demethylation?

Biomolecular Concepts, 2012
Dynamic DNA methylation is a prerequisite for many developmental processes and maintenance of cellular integrity. In mammals however, mechanisms of active DNA demethylation have for long been elusive.
Véron Nathalie
doaj   +1 more source

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro

Nucleic Acids Research, 2019
5-Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for mammalian gene regulation. It is oxidized to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the ten-eleven translocation (TET ...
Ke Bian, S. Lenz, Qi Tang, Fangyi Chen, Rui Qi, M. Jost, C. Drennan, J. Essigmann, S. Wetmore, Deyu Li   +9 more
semanticscholar   +1 more source

Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.

PLoS ONE, 2013
During mammalian development the fertilized zygote and primordial germ cells lose their DNA methylation within one cell cycle leading to the concept of active DNA demethylation.
Daniel Nettersheim, Lukas C Heukamp, Florian Fronhoffs, Marc J Grewe, Natalie Haas, Anke Waha, Friedemann Honecker, Andreas Waha, Glen Kristiansen, Hubert Schorle   +9 more
doaj   +1 more source

5'-Methylcytosine and 5'-hydroxymethylcytosine each provide epigenetic information to the mouse zygote.

PLoS ONE, 2013
Covalent modification of cytosine nucleotides within the genome encode essential epigenetic information, with methylation (5meC) and hydroxymethylation (5hmC) having received most attention.
Yan Li, Chris O'Neill
doaj   +1 more source

YBX1 Promotes Esophageal Squamous Cell Carcinoma Progression via m5C‐Dependent SMOX mRNA Stabilization

Advanced Science
The modification and recognition of 5‐methylcytosine (m5C) are involved in the initiation and progression of various tumor types. However, the precise role and potential mechanism of Y‐box‐binding protein 1 (YBX1) in esophageal squamous cell carcinoma ...
Liwen Liu, Yu Chen, Tao Zhang, Guangying Cui, Weiwei Wang, Guizhen Zhang, Jianhao Li, Yize Zhang, Yun Wang, Yawen Zou, Zhigang Ren, Wenhua Xue, Ranran Sun   +12 more
doaj   +1 more source

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Science, 2009
Mamta Tahiliani, Kian Peng Koh, Yinghua Shen, W. Pastor, Hozefa S. Bandukwala, Y. Brudno, Suneet Agarwal, L. Iyer, David R. Liu, L. Aravind, A. Rao   +10 more
semanticscholar   +1 more source

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

Proceedings of the National Academy of Sciences of the United States of America, 1992
M. Frommer, Louise E. McDonald, D. Millar, C. M. Collis, F. Watt, G. Grigg, P. Molloy, C. Paul   +7 more
semanticscholar   +1 more source

Quantification of cytosine modifications in the aged mouse brain

Neuropsychopharmacology Reports
Quantifying cytosine modifications in various brain regions provides important insights into the gene expression regulation and pathophysiology of neuropsychiatric disorders.
Hiroko Sugawara, Akitoshi Date, Satoshi Fuke, Yutaka Nakachi, Tadafumi Kato, Minoru Narita, Miki Bundo, Kazuya Iwamoto   +7 more
doaj   +1 more source

5-Methylcytosine [PDF]

, 2020
openaire   +1 more source