RNA 5-Methylcytosine Modification in Myocardial Fibrosis [PDF]
Reviews in Cardiovascular MedicineMyocardial fibrosis represents a common pathological hallmark of various cardiovascular diseases progressing to heart failure, with the immunoinflammatory response playing a pivotal role in the pathogenesis of myocardial fibrosis.
Bohan Li, Yan Hao, Wendan Tian, Wei Liu
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Determination of the presence of 5-methylcytosine in Paramecium tetraurelia. [PDF]
PLoS ONE, 2018 5-methylcytosine DNA methylation regulates gene expression and developmental programming in a broad range of eukaryotes. However, its presence and potential roles in ciliates, complex single-celled eukaryotes with germline-somatic genome specialization ...
Aditi Singh +5 more
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Immunodetection of 5′-methylcytosine on Giemsa-stained chromosomes [PDF]
BioTechniques, 2005 BioTechniques 527 In higher vertebrates, the major, if not the only, covalent modification of DNA is a methyl-group present at the C5 position of cytosine yielding 5′-methylcytosine (5′-MC). This modification occurs only in the context of CpG dinucleotides, short sequences that are significantly underrepresented in the genome but are found frequently ...
Werner Pfarr +3 more
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DNA of Drosophila melanogaster contains 5‐methylcytosine [PDF]
EMBO Journal, 2000 It is commonly accepted that the DNA of Drosophila melanogaster does not contain 5-methylcytosine, which is essential in the development of most eukaryotes. We have developed a new, highly specific and sensitive assay to detect the presence of 5-methylcytosine in genomic DNA.
Albert Jeltsch, Humaira Gowher
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Genome‐Wide 5‐Methylcytosine and 5‐Hydroxymethylcytosine Signatures Analysis of Plasma Cell‐Free DNA in Schizophrenia [PDF]
MedCommSchizophrenia (SCZ) is a highly heritable neuropsychiatric disorder that affects ∼1% of people globally. Despite extensive research, there remains a lack of biomarkers for SCZ diagnosis and disease pathogenesis delineation.
Gang Xue +13 more
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UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures
Epigenetics, 2017 The 5-methylcytosine (5mC) modification regulates multiple cellular processes and is faithfully maintained following DNA replication. In addition to DNA methyltransferase (DNMT) family proteins, ubiquitin-like PHD and ring finger domain-containing ...
Xiaochun Yu, Jack M Parent, Yidan Liu
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5-Methylcytosine methylation predicts cervical cancer prognosis, shaping immune cell infiltration [PDF]
Journal of International Medical ResearchBackground Epigenetics, encompassing DNA and RNA modifications, has emerged as a prominent area of research in the post-genomic era. Numerous studies have elucidated the impact of epigenetics on tumor regulation.
Luyang Su +8 more
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Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing [PDF]
eLife5-Methylcytosine (m5C) is one of the posttranscriptional modifications in mRNA and is involved in the pathogenesis of various diseases. However, the capacity of existing assays for accurately and comprehensively transcriptome-wide m5C mapping still needs
Jiale Zhou +13 more
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5-Methylcytosine RNA Methylation in Arabidopsis Thaliana [PDF]
Molecular Plant, 2017 5-Methylcytosine (m5C) is a well-characterized DNA modification, and is also predominantly reported in abundant non-coding RNAs in both prokaryotes and eukaryotes. However, the distribution and biological functions of m5C in plant mRNAs remain largely unknown.
Zhe Liang, Lisha Shen, Hao Yu
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5-methylcytosine regulated CCNL2 promotes tumorigenesis and cisplatin resistance of ovarian cancer with therapeutic implications [PDF]
Journal of Ovarian ResearchBackgroud Ovarian cancer (OC) is the most lethal gynecological tumor, primarily due to resistance to chemotherapy. Cyclin L2 (CCNL2) is a novel member of the cyclin family and mainly localized in nucleus.
Kai Zhang +5 more
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