RNA 5-Methylcytosine Modification in Myocardial Fibrosis [PDF]
Reviews in Cardiovascular MedicineMyocardial fibrosis represents a common pathological hallmark of various cardiovascular diseases progressing to heart failure, with the immunoinflammatory response playing a pivotal role in the pathogenesis of myocardial fibrosis.
Bohan Li, Yan Hao, Wendan Tian, Wei Liu
doaj +2 more sources
Genome‐Wide 5‐Methylcytosine and 5‐Hydroxymethylcytosine Signatures Analysis of Plasma Cell‐Free DNA in Schizophrenia [PDF]
MedCommSchizophrenia (SCZ) is a highly heritable neuropsychiatric disorder that affects ∼1% of people globally. Despite extensive research, there remains a lack of biomarkers for SCZ diagnosis and disease pathogenesis delineation.
Gang Xue +13 more
doaj +2 more sources
5-Methylcytosine methylation predicts cervical cancer prognosis, shaping immune cell infiltration [PDF]
Journal of International Medical ResearchBackground Epigenetics, encompassing DNA and RNA modifications, has emerged as a prominent area of research in the post-genomic era. Numerous studies have elucidated the impact of epigenetics on tumor regulation.
Luyang Su +8 more
doaj +2 more sources
Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing [PDF]
eLife5-Methylcytosine (m5C) is one of the posttranscriptional modifications in mRNA and is involved in the pathogenesis of various diseases. However, the capacity of existing assays for accurately and comprehensively transcriptome-wide m5C mapping still needs
Jiale Zhou +13 more
doaj +2 more sources
5-methylcytosine regulated CCNL2 promotes tumorigenesis and cisplatin resistance of ovarian cancer with therapeutic implications [PDF]
Journal of Ovarian ResearchBackgroud Ovarian cancer (OC) is the most lethal gynecological tumor, primarily due to resistance to chemotherapy. Cyclin L2 (CCNL2) is a novel member of the cyclin family and mainly localized in nucleus.
Kai Zhang +5 more
doaj +2 more sources
Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease [PDF]
Advanced ScienceAlzheimer's disease (AD) is associated with genetic risk factors and widespread epigenetic alterations. 5‐Hydroxymethylcytosine (5hmC), an oxidized derivative of 5‐methylcytosine (5mC), constitutes up to 20% of 5mC in neuronal DNA and is implicated in ...
Zi‐Xin Wang +15 more
doaj +2 more sources
Epigenetics of Modified DNA Bases: 5-Methylcytosine and Beyond
Frontiers in Genetics, 2018 Modification of DNA bases plays vital roles in the epigenetic control of gene expression in both animals and plants. Though much attention is given to the conventional epigenetic signature 5-methylcytosine (5-mC), the field of epigenetics is attracting ...
, Viswanathan Chinnusamy, T Mohapatra
exaly +3 more sources
Frontiers in Genetics, 2022 Background: 5-methylcytosine has a profound impact on the development and progression of hepatocellular carcinoma. The aim of this study was to investigate the usefulness of 5-methylcytosine in determining the prognosis, tumor microenvironment, and ...
Mingyuan Luan +4 more
doaj +1 more source
Identification and validation of 5-methylcytosine-associated genes in diffuse large B-cell lymphoma
Heliyon, 2023 5-methylcytosine modifications play a significant role in carcinogenesis; however, studies exploring 5-methylcytosine-related genes in diffuse large B-cell lymphoma patients are lacking.
Cheng Xing +14 more
doaj +1 more source
BioChem, 2022 Three forms of methylated cytosines are present in the eukaryotic genome: 3-methylcytosine, 4-methylcytosine and 5-methylcytosine. 3-methylcytosines create methyl lesions, which impair local DNA function and flexibility, resulting in replication and ...
Aninda Sundar Dey
doaj +1 more source