Cell identity and 5-hydroxymethylcytosine [PDF]
Epigenetics & ChromatinEpigenetic factors underlie cellular identity through the regulation of transcriptional networks that establish a cell’s phenotype and function. Cell conversions are directed by transcription factor binding at target DNA which induce changes to identity ...
Floris Honig, Adele Murrell
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Angewandte Chemie, EarlyView.The carbocyclic Decitabine analog (cAzadC) incorporates as an antimetabolite weakly into the genome of growing tumor cells, where it triggers a genome‐wide demethylation and a surprisingly strong hydroxymethylation of cytosine, which translates into an efficient in vivo antitumor (AML) effect.
Däther M +17 more
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Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer’s disease neuropathology [PDF]
Nature Communications5-hydroxymethylcytosine, also known as the sixth DNA base of the genome, plays an important role in brain aging and neurological disorders such as Alzheimer’s disease.
Jinying Zhao +18 more
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5‐Hydroxymethylcytosine: a new kid on the epigenetic block?
Molecular Systems Biology, 2011 The discovery of the Ten‐Eleven‐Translocation (TET) oxygenases that catalyze the hydroxylation of 5‐methylcytosine (5mC) to 5‐hydroxymethylcytosine (5hmC) has triggered an avalanche of studies aiming to resolve the role of 5hmC in gene regulation if any.
Filomena Matarese +1 more
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Genome‐Wide 5‐Methylcytosine and 5‐Hydroxymethylcytosine Signatures Analysis of Plasma Cell‐Free DNA in Schizophrenia [PDF]
MedCommSchizophrenia (SCZ) is a highly heritable neuropsychiatric disorder that affects ∼1% of people globally. Despite extensive research, there remains a lack of biomarkers for SCZ diagnosis and disease pathogenesis delineation.
Gang Xue +13 more
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5-Hydroxymethylcytosine signatures as diagnostic biomarkers for septic cardiomyopathy [PDF]
Scientific ReportsAt present, there are currently no molecular biomarkers for the early diagnosis of sepsis cardiomyopathy (SCM) in clinical practice. This study focuses on an in-depth examination of the DNA hydroxymethylation profiles within plasma extracellular vesicles
Baixin Zhen +7 more
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Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation [PDF]
BMC BiologyBackground Colorectal cancer (CRC) progression from adenoma to adenocarcinoma is associated with global reduction in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). DNA hypomethylation continues upon liver metastasis.
Ben Murcott +13 more
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Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease [PDF]
Advanced ScienceAlzheimer's disease (AD) is associated with genetic risk factors and widespread epigenetic alterations. 5‐Hydroxymethylcytosine (5hmC), an oxidized derivative of 5‐methylcytosine (5mC), constitutes up to 20% of 5mC in neuronal DNA and is implicated in ...
Zi‐Xin Wang +15 more
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5-Hydroxymethylcytosine Loss in Conjunctival Melanoma
Dermatopathology, 2021 Aims: Conjunctival and cutaneous melanoma partially share similar clinical and molecular backgrounds. As 5-hydroxymethylcytosine (5-hmC) loss has been demonstrated in cutaneous melanoma, we decided to assess if similar changes were occurring in ...
Alexandre Stahl +5 more
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Hydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer
Scientific Reports, 2022 Early detection of cancer will improve survival rates. The blood biomarker 5-hydroxymethylcytosine has been shown to discriminate cancer. In a large covariate-controlled study of over two thousand individual blood samples, we created, tested and explored
Nicolas J. Walker +44 more
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