Results 11 to 20 of about 16,942 (208)

Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease [PDF]

npj Parkinson's Disease, 2017
5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains.
Reinhard Stöger, Paula J. Scaife, Freya Shephard, Lisa Chakrabarti   +3 more
doaj   +3 more sources

The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases [PDF]

Frontiers in Neuroscience, 2014
DNA methylation primarily occurs within human cells as a 5-methylcytosine (5mC) modification of the cytosine bases in CpG dinucleotides. 5mC has proven to be an important epigenetic mark that is involved in the control of gene transcription for processes
Sahar eAl-Mahdawi, Sahar eAl-Mahdawi, Sara eAnjomani Virmouni, Sara eAnjomani Virmouni, Mark Adrian Pook, Mark Adrian Pook   +5 more
doaj   +3 more sources

5-Methylcytosine and 5-Hydroxymethylcytosine Signatures Underlying Pediatric Cancers [PDF]

Epigenomes, 2019
In addition to the genetic variations, recent evidence has shown that DNA methylation of both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) underlies the pathogenesis of pediatric cancer. Given the high mortality rate, there is an urgent need to study the mechanisms contributing to the pathogenicity of pediatric cancer.
Shalu Jhanwar, Ajinkya Deogade
openaire   +5 more sources

5-Hydroxymethylcytosine is a predominantly stable DNA modification [PDF]

Nature Chemistry, 2014
5-Hydroxymethylcytosine (hmC) is an oxidation product of 5-methylcytosine which is present in the deoxyribonucleic acid (DNA) of most mammalian cells. Reduction of hmC levels in DNA is a hallmark of cancers. Elucidating the dynamics of this oxidation reaction and the lifetime of hmC in DNA is fundamental to understanding hmC function.
Bachman, Martin, Uribe-Lewis, Santiago, Yang, Xiaoping, Williams, Michael, Murrell, Adele, Balasubramanian, Shankar   +5 more
openaire   +6 more sources

Distribution of 5-Hydroxymethylcytosine in Different Human Tissues [PDF]

Journal of Nucleic Acids, 2011
5-hydroxymethylcytosine (5-hmC) is a modified form of cytosine recently found in mammalians and is believed, like 5-methylcytosine, to also play an important role in switching genes on and off. By utilizing a newly developed 5-hmC immunoassay, we determined the abundance of 5-hmC in human tissues and compared 5-hmC states in normal colorectal tissue ...
Weiwei Li, Min Liu
openaire   +3 more sources

The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing [PDF]

PLoS ONE, 2010
We recently showed that enzymes of the TET family convert 5-mC to 5-hydroxymethylcytosine (5-hmC) in DNA. 5-hmC is present at high levels in embryonic stem cells and Purkinje neurons. The methylation status of cytosines is typically assessed by reaction with sodium bisulfite followed by PCR amplification.
Huang, Yun, Pastor, William Abraham, Shen, Yinghua, Tahiliani, Mamta V., Liu, David, Rao, Anjana, Liu, Jun   +6 more
openaire   +5 more sources

Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer's disease neuropathology. [PDF]

Nat Commun
5-hydroxymethylcytosine, also known as the sixth DNA base of the genome, plays an important role in brain aging and neurological disorders such as Alzheimer’s disease.
Zhao J, Gu T, Gao C, Miao G, Palma-Gudiel H, Yu L, Yang J, Wang Y, Li Y, Lim J, Li R, Yao B, Wu H, Schneider JA, Seyfried N, Grodstein F, De Jager PL, Jin P, Bennett DA.   +18 more
europepmc   +2 more sources

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme [PDF]

, 2015
5-hydroxymethylcytosine is a new epigenetic modification deriving from the oxidation of 5-methylcytosine by the TET hydroxylase enzymes. DNA hydroxymethylation drives DNA demethylation events and is involved in the control of gene expression ...
CAIAFA, Paola, CICCARONE, FABIO, VALENTINI, ELISABETTA, ZAMPIERI, Michele   +3 more
core   +12 more sources

Genome-Wide 5-Methylcytosine and 5-Hydroxymethylcytosine Signatures Analysis of Plasma Cell-Free DNA in Schizophrenia. [PDF]

MedComm (2020)
Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder that affects ∼1% of people globally. Despite extensive research, there remains a lack of biomarkers for SCZ diagnosis and disease pathogenesis delineation.
Xue G, Wei X, Li L, Zhang Q, Liu S, Zhang J, Hu W, Zhao Q, Zhang W, Luo C, Gong Q, Zhang B, Xie D, Lui S.   +13 more
europepmc   +2 more sources

5-Hydroxymethylcytosine signatures as diagnostic biomarkers for septic cardiomyopathy. [PDF]

Sci Rep
At present, there are currently no molecular biomarkers for the early diagnosis of sepsis cardiomyopathy (SCM) in clinical practice. This study focuses on an in-depth examination of the DNA hydroxymethylation profiles within plasma extracellular vesicles
Zhen B, Zhao Z, Chen H, Li W, Zhang L, Zhu X, Ge Q, Lin J.   +7 more
europepmc   +2 more sources