Results 1 to 10 of about 2,171 (168)
Global DNA 5hmC and CK195hmC+ Contents: A Promising Biomarker for Predicting Prognosis in Small Hepatocellular Carcinoma [PDF]
Current Oncology, 2021 Background: 5-Hydroxymethylcytosine (5hmC) with dynamic existence possesses multiple regulatory functions. Whereas, 5hmC’s impact on small hepatocellular carcinoma (SHCC) remains unclear.
Jinhua Jiang, Tinghua Yan, Fang Guo
doaj +4 more sources
TET-mediated 5hmC in breast cancer: mechanism and clinical potential
EpigeneticsBreast cancer is the most common cancer among women, with differences in clinical features due to its distinct molecular subtypes. Current studies have demonstrated that epigenetic modifications play a crucial role in regulating the progression of breast cancer.
Jiahang Zhang, Siwei Ju, Xixi Lin
exaly +5 more sources
5-Hydroxymethylcytosine (5hmC), or How to Identify Your Favorite Cell
Epigenomes, 2018 Recently described as the sixth base of the DNA macromolecule, the precise role of 5-hydroxymethylcytosine (5hmC) is the subject of debate. Early studies indicate that it is functionally distinct from cytosine DNA methylation (5mC), and there is evidence for 5hmC being a stable derivate of 5mC, rather than just an intermediate of demethylation ...
Jesus Rafael Rodríguez-Aguilera +2 more
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IDH1/2 Mutants Inhibit TET-Promoted Oxidation of RNA 5mC to 5hmC. [PDF]
PLoS ONE, 2016 TETs (TET1/2/3) play critical roles in multi cellular processes through DNA demethylation driven by oxidation of DNA 5mdC to 5hmdC. Interestingly, recent studies indicated that TETs also oxidate RNA 5mC to 5hmC.
Qiang Xu +6 more
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Crystal structure of the 5hmC specific endonuclease PvuRts1I [PDF]
Nucleic Acids Research, 2014 PvuRts1I is a prototype for a larger family of restriction endonucleases that cleave DNA containing 5-hydroxymethylcytosine (5hmC) or 5-glucosylhydroxymethylcytosine (5ghmC), but not 5-methylcytosine (5mC) or cytosine. Here, we report a crystal structure of the enzyme at 2.35 Å resolution.
Kazrani, A. A. +3 more
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Signal Transduction and Targeted Therapy, 2022 DNA methylation is a reversible process catalyzed by the ten–eleven translocation (TET) family of enzymes (TET1, TET2, TET3) that convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC).
Hernando Lopez-Bertoni +2 more
exaly +2 more sources
Neuron and astrocyte specific 5mC and 5hmC signatures of BDNF’s receptor, TrkB
Frontiers in Molecular NeuroscienceBrain derived neurotrophic factor (BDNF) is the most studied trophic factor in the central nervous system (CNS), and its role in the maturation of neurons, including synapse development and maintenance has been investigated intensely for over three decades.
Xiaoran Wei +2 more
exaly +4 more sources
Epigenetics, 2023 Background: Elucidating epigenetic mechanisms could provide new biomarkers for disease diagnosis and prognosis. Technological advances allow genome-wide profiling of 5-hydroxymethylcytosines (5hmC) in liquid biopsies.
Lu Gao +7 more
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Exploring role of 5hmC as potential marker of chemoresistance [PDF]
Molecular & Cellular Oncology, 2020 Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance mechanisms are unknown. Our recent findings shed light on one such unknown mechanism. We identified
Suhas S. Kharat, Shyam K. Sharan
openaire +3 more sources
Clinical Epigenetics, 2023 Background A growing body of research has emphasized 5-hydroxymethylcytosine (5hmC) as an important epigenetic mark. High-resolution methods to detect 5hmC require high sequencing depth and are therefore expensive. Many studies have used enrichment-based
Jaywon Lee +4 more
doaj +1 more source