Results 41 to 50 of about 2,171 (168)
, 2019 Cell-free DNA (cfDNA)-based biomarkers such as mutation and methylation offer promising noninvasive strategies for disease diagnosis and prognosis. However, besides high-throughput sequencing, there has been no alternative approach to date to detect the ...
Fang Yuan (96264) +3 more
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Chemical Structures of 2′-deoxynucleosides containing 5hmU, 5hmC, base J and Glc-5hmC.
, 2014 Chemical Structures of 2′-deoxynucleosides containing 5hmU, 5hmC, base J and Glc-5hmC.
Debin Ji (604255), Yinsheng Wang (8699)
core +1 more source
PLoS ONE, 2015 The Infinium 450K Methylation array is an established tool for measuring methylation. However, the bisulfite (BS) reaction commonly used with the 450K array cannot distinguish between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC).
Sarah F Field +5 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2023 Tetrachlorobenzoquinone (TCBQ) is an active metabolite of pentachlorophenol, and stimulates the accumulation of ROS to trigger apoptosis. The preventive effect of vitamin C (Vc) against TCBQ-induced apoptosis in HepG2 cells is unknown.
Cuiping Li +8 more
doaj +1 more source
Advances in the joint profiling technologies of 5mC and 5hmC
RSC Chemical BiologyOverview of the joint profiling technologies of 5mC and 5hmC.
Bo He, Haojun Yao, Chengqi Yi
openaire +2 more sources
Representative 5hmC staining in glioma.
, 2012 Human brain tumor tissue sections were stained with hematoxylin and eosin (A–D) or with antibodies specific for 5hmC (E–H). Relatively high levels of 5hmC staining was seen in pilocytic astroycytomas (E) and oligodendrogliomas (F).
Brent A. Orr (150119) +4 more
core +1 more source
Dynamics of 5-Hydroxymethylcytosine and Chromatin Marks in Mammalian Neurogenesis
Cell Reports, 2013 DNA methylation in mammals is highly dynamic during germ cell and preimplantation development but is relatively static during the development of somatic tissues.
Maria A. Hahn +10 more
doaj +1 more source
Diversity of Two Forms of DNA Methylation in the Brain
Frontiers in Genetics, 2014 DNA methylation 5-methylcytosine (5mC) predicts a compacting chromatin inaccessible to transcription. The discovery of 5-hydroxymethylcytosine (5hmC), which is derived from 5mC, adds a new dimension to the mechanism and role of DNA methylation in ...
Yuanyuan eChen +4 more
doaj +1 more source
Nature Communications, 2020 DNA 5-hydroxymethylcytosine (5hmC) modification is associated with gene transcription and used as a mark of mammalian development. Here the authors report a comprehensive 5hmC tissue map and analysis of 5hmC genomic distributions in 19 human tissues ...
Xiao-Long Cui +24 more
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source