Results 31 to 40 of about 2,171 (168)
Regulation and Functional Significance of 5-Hydroxymethylcytosine in Cancer
Epigenomes, 2017 Epigenetic modes of gene regulation are important for physiological conditions and its aberrant changes can lead to disease like cancer. 5-hydroxymethylcytosine (5hmC) is an oxidized form of 5-methylcytosine (5mC) catalyzed by Ten Eleven Translocation ...
Vittal Rangan Arvinden +3 more
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Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes [PDF]
, 2011 The discovery of substantial amounts of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5-methylcytosine (5mC), in various mouse tissues and human embryonic stem (ES) cells has necessitated a reevaluation of our knowledge of 5mC/5hmC patterns ...
Sproul, Duncan +34 more
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Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies. [PDF]
PLoS ONE, 2016 Solid tumors are characterized by a plethora of epigenetic changes. In particular, patterns methylation of cytosines at the 5-position (5mC) in the context of CpGs are frequently altered in tumors. Recent evidence suggests that 5mC can get converted to 5-
Enrico Munari +10 more
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Alterations in the Genomic Distribution of 5hmC in In Vivo Aged Human Skin Fibroblasts [PDF]
International Journal of Molecular Sciences, 2020 5-Hydroxymethylcytosine (5hmC) is a functionally active epigenetic modification. We analyzed whether changes in DNA 5-hydroxymethylation are an element of age-related epigenetic drift. We tested primary fibroblast cultures originating from individuals aged 22–35 years and 74–94 years.
Paulina Kołodziej-Wojnar +7 more
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Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease [PDF]
npj Parkinson's Disease, 2017 Abstract5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immunosorbent assay in DNA from post-mortem cerebella of individuals with Parkinson’s disease and ...
Reinhard Stöger +3 more
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Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer
Clinical Epigenetics, 2018 Background 5-Hydroxymethylcytosine (5hmC) is converted from 5-methylcytosine (5mC) by a group of enzymes termed ten-eleven translocation (TET) family dioxygenases.
Ding Peng +16 more
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, 2023 DNA methylation and hydroxymethylation at the 5-position of cytosine (5mC) are essential epigenetic alterations that play vital roles in gene expression regulation and cell differentiation. DNA methylation typically represses gene transcription. Hydroxymethylation, on the contrary, activates gene expression or prompts DNA demethylation.
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Epigenetics, 2018 DNA methylation (5-methylcytosine, 5 mC) is involved in many cellular processes and is an epigenetic mechanism primarily associated with transcriptional repression.
Jose Ramon Hernandez Mora +6 more
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5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability
Cell Reports, 2016 5-hydroxymethylcytosine (5hmC) is a DNA base created during active DNA demethylation by the recently discovered TET enzymes. 5hmC has essential roles in gene expression and differentiation.
Georgia Rose Kafer +6 more
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TET Enzymes and 5-Hydroxymethylcytosine in Neural Progenitor Cell Biology and Neurodevelopment
Frontiers in Cell and Developmental Biology, 2021 Studies of tissue-specific epigenomes have revealed 5-hydroxymethylcytosine (5hmC) to be a highly enriched and dynamic DNA modification in the metazoan nervous system, inspiring interest in the function of this epigenetic mark in neurodevelopment and ...
Ian C. MacArthur +5 more
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