Results 11 to 20 of about 2,171 (168)
TET2 Promotes Keloid Hyperplasia by Regulating 5hmC Modification in the TGFβ Promoter Region
Clinical, Cosmetic and Investigational Dermatology, 2023 Changying Niu,1 Shenxing Tan2 1Dermatological Department, Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of China; 2Plastic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, People’s Republic of ...
Niu C, Tan S
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ELISA-Based Quantitation of Global 5hmC Levels [PDF]
, 2021 5-Hydroxymethylcytosine (5hmC) is an abundant DNA modification in human and mouse brain, as well as in embryonic stem cells, while severely depleted in multiple types of cancer. Assays for 5hmC detection and quantification, both on a locus-specific and global level, are limited in number and often resource-intensive.
Olova, Nelly N.; id_orcid +1 more
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Avidin-Biotin ELISA-Based Detection of 5hmC [PDF]
, 2021 The enzyme-linked immunosorbent assay (ELISA) technique has been developed half a century ago, and yet its role in molecular biology remains significant. Among the most sensitive of immunoassays, it offers high throughput, combined with affordability and ease of use.
Olova, Nelly N.; id_orcid +1 more
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From development to diseases: The role of 5hmC in brain
Genomics, 2014 Epigenetic modulations play essential roles in diverse biological processes. During the past several years, DNA demethylation has been discovered in embryonic and postnatal development. Although some potential functions of DNA methylation have been demonstrated already, many questions remain in terms of unveiling the role of 5hmC; whether it serves ...
Sun, Wenjia +3 more
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Integrating 5hmC and gene expression data to infer regulatory mechanisms [PDF]
Bioinformatics, 2017 Abstract Motivation Epigenetic mechanisms are known to play a major role in breast cancer. However, the role of 5-hydroxymethylcytosine (5hmC) remains understudied. We hypothesize that 5hmC mediates redox regulation of gene expression in an aggressive subtype known as triple negative breast cancer ...
Cristina Mitrea +6 more
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New Insights into 5hmC DNA Modification: Generation, Distribution and Function [PDF]
Frontiers in Genetics, 2017 Dynamic DNA modifications, such as methylation/demethylation on cytosine, are major epigenetic mechanisms to modulate gene expression in both eukaryotes and prokaryotes. In addition to the common methylation on the 5th position of the pyrimidine ring of cytosine (5mC), other types of modifications at the same position, such as 5-hydroxymethyl (5hmC), 5-
Shi, Dong-Qiao +3 more
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Chemical tools to study 5hmC, a modified DNA base
, 2015 La 5-hydroxymethylcytosine (5hmC) est une base modifiée de l'ADN. Chez le mammifère, cette base était considérée jusqu'à récemment comme une espèce mineure produite par des dommages oxydatifs. Cependant, des travaux publiés en 2009 ont profondément changé cette vision. En effet, d'une part, la 5hmC est abondante dans certains types cellulaires, d'autre
Gerard-Hirne, Tom
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Neoplasia: An International Journal for Oncology Research, 2020 Background: DNA methylation at the fifth position of cytosine (5mC) is a common epigenetic alteration affecting a range of cellular processes. In recent years, 5-hydroxymethylcytosine (5hmC), an oxidized form of 5mC, has risen broad interests as a ...
Zhihui Wang +11 more
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Frontiers in Genetics, 2021 5-Hydroxymethylcytosine (5hmC), the oxidative product of 5-methylcytosine (5mC) catalyzed by ten-eleven translocation enzymes, plays an important role in many biological processes as an epigenetic mediator.
Xiaogang Li +9 more
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Frontiers in Genetics, 2023 Background: Oral squamous cell carcinoma (OSCC) is one of the most common types of cancer worldwide. Although overall losses of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have been previously observed, a genome-wide, single-base-resolution,
Weizhi Zhao +14 more
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