Results 21 to 30 of about 8,428,479 (200)
Supplementary Table from The 5-Hydroxymethylcytosine Landscape of Prostate Cancer
, 2022 Supplementary Table from The 5-Hydroxymethylcytosine Landscape of Prostate ...
Matti Annala (219688) +63 more
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Cancer Biology & Therapy, 2013 DNA methylation at the 5 position of cytosine (5-mC) has emerged as a key epigenetic marker that plays essential roles in various biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the ten-eleven translocation (TET) family proteins, which is now widely recognized as the "sixth base" in the mammalian ...
Chao, Ye, Lan, Li
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eLife, 2021 Although high levels of 5-hydroxymethylcytosine (5hmC) accumulate in mammalian neurons, our knowledge of its roles in terminal differentiation or as an intermediate in active DNA demethylation is incomplete.
Elitsa Stoyanova +3 more
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The Hunt for 5-Hydroxymethylcytosine: The Sixth Base [PDF]
Epigenomics, 2011 transfers a glucose from UDP-glucose to 5-hmC in T4 bacteriophages. Two groups independently reported the use of b-GT to detect and quantify 5-hmC. Szwagierczak et al. used H radioactive glucose to label and quantify 5-hmC by scintillation counting [10]. Song et al.
Chun-Xiao, Song, Chuan, He
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Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes [PDF]
, 2011 The discovery of substantial amounts of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5-methylcytosine (5mC), in various mouse tissues and human embryonic stem (ES) cells has necessitated a reevaluation of our knowledge of 5mC/5hmC patterns ...
Sproul, Duncan +34 more
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Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue
Epigenetics, 2020 Despite recent evidence that 5-hydroxymethylcytosine (5hmC) possesses roles in gene regulation distinct from 5-methylcytosine (5mC), relatively little is known regarding the functions of 5hmC in mammalian tissues.
Owen M. Wilkins +5 more
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Cell‐free DNA 5‐hydroxymethylcytosine as a marker for common cancer detection
Clinical and Translational Discovery, 2022 Background Early cancer detection can dramatically improve clinical outcomes and greatly reduce economic burden of patients. Plasma cell–free DNA (cfDNA) 5‐hydroxymethylcytosine (5hmC) is an emerging epigenetic marker for cancer diagnosis.
Jianming Shao +3 more
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Integrated single-cell sequencing of 5-hydroxymethylcytosine and genomic DNA using scH&G-seq
STAR Protocols, 2021 Summary: The asymmetric distribution of 5-hydroxymethylcytosine (5hmC) between two DNA strands of a chromosome enables endogenous reconstruction of cellular lineages at an individual-cell-division resolution. Further, when integrated with data on genomic
Alex Chialastri +2 more
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Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. [PDF]
, 2010 5-Hydroxymethylcytosine (hmC) was recently detected as the sixth base in mammalian tissue at so far controversial levels. The function of the modified base is currently unknown, but it is certain that the base is generated from 5-methylcytosine (mC ...
Biel, Martin +26 more
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Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus [PDF]
, 2013 © 2013 Al-Mahdawi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are ...
Pook, MA +11 more
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