Results 21 to 30 of about 16,942 (208)

Hydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer

Scientific Reports, 2022
Early detection of cancer will improve survival rates. The blood biomarker 5-hydroxymethylcytosine has been shown to discriminate cancer. In a large covariate-controlled study of over two thousand individual blood samples, we created, tested and explored
Nicolas J. Walker, Mamunur Rashid, Shirong Yu, Helen Bignell, Casper K. Lumby, Carmen M. Livi, Kate Howell, David J. Morley, Sandro Morganella, Daniel Barrell, Shabhonam Caim, Walraj Gosal, Jens Füllgrabe, Thomas J. Charlesworth, Louella Vasquez, Miika Ahdesmäki, Jordan Eizenga, Parul Prabhat, Vitali Proutski, Marie Laurie Murat-Onana, Catherine J. Greenwood, Lisa Kirkwood, Meeta Maisuria-Armer, Mengjie Li, Emma Coats, Victoria Winfield, Lachlan MacBean, Toby Stock, Alice Tomé-Fernandez, Yat Chan, Nasir Sheikh, Paula Golder, Michael Steward, Tobias W. B. Ost, Douglas Stewart, Albert Vilella, Mojtaba Noursalehi, Benedict Paten, Debora Lucarelli, Joanne Mason, Gareth Ridge, Jason Mellad, Suman Shirodkar, Shankar Balasubaramanian, Joanna D. Holbrook   +44 more
doaj   +1 more source

Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation. [PDF]

BMC Biol
Background Colorectal cancer (CRC) progression from adenoma to adenocarcinoma is associated with global reduction in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). DNA hypomethylation continues upon liver metastasis.
Murcott B, Honig F, Halliwell DO, Tian Y, Robson JL, Manasterski P, Pinnell J, Dix-Peek T, Uribe-Lewis S, Ibrahim AEK, Sero J, Gurevich D, Nikolaou N, Murrell A.   +13 more
europepmc   +2 more sources

5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function

eLife, 2021
Although high levels of 5-hydroxymethylcytosine (5hmC) accumulate in mammalian neurons, our knowledge of its roles in terminal differentiation or as an intermediate in active DNA demethylation is incomplete.
Elitsa Stoyanova, Michael Riad, Anjana Rao, Nathaniel Heintz   +3 more
doaj   +1 more source

Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus [PDF]

, 2013
© 2013 Al-Mahdawi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are ...
A Dürr, A Filla, A Saveliev, A Wong, AH Koeppen, Annalisa Pastore, C Sandi, Chiranjeevi Sandi, D Globisch, E Grabczyk, E Greene, E Kim, GN Filippova, H Chen, H Holemon, H Stroud, I Castaldo, I De Biase, I De Biase, J Robertson, JL Bradley, JU Guo, KE Szulwach, M Mellén, M Pandolfo, M Tahiliani, Mark A. Pook, MC Haffner, MR Branco, MV Evans-Galea, N Chia, PK Chan, R Sharma, RD Wells, Ricardo Mouro Pinto, S Al-Mahdawi, S Kriaucionis, Sahar Al-Mahdawi, T Wang, V Campuzano, V Campuzano, Y Huang   +41 more
core   +11 more sources

Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI [PDF]

, 2017
Background: Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmetric between the paternal and the ...
De Schauwer, Catharina, Heras Garcia, Sonia, Smits, Katrien, Van Soom, Ann   +3 more
core   +1 more source

Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors [PDF]

, 2015
DNA methylation is the most well studied epigenetic modification in cancer biology. 5-hydroxymethylcytosine is an epigenetic mark that can be converted from 5-methylcytosine by the ten-eleven translocation gene family.
Dresser, Karen, Larson, Allison R., Lezcano, Cecilia, Lian, Christine Guo, Mihm, Martin C., Murphy, George F., Scolyer, Richard A., Shi, Yujiang G., Thompson, John F., Woda, Bruce A., Yosufi, Benafsha, Zhan, Qian   +11 more
core   +1 more source

Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue

Epigenetics, 2020
Despite recent evidence that 5-hydroxymethylcytosine (5hmC) possesses roles in gene regulation distinct from 5-methylcytosine (5mC), relatively little is known regarding the functions of 5hmC in mammalian tissues.
Owen M. Wilkins, Kevin C. Johnson, E. Andres Houseman, Jessica E. King, Carmen J. Marsit, Brock C. Christensen   +5 more
doaj   +1 more source

Cell‐free DNA 5‐hydroxymethylcytosine as a marker for common cancer detection

Clinical and Translational Discovery, 2022
Background Early cancer detection can dramatically improve clinical outcomes and greatly reduce economic burden of patients. Plasma cell–free DNA (cfDNA) 5‐hydroxymethylcytosine (5hmC) is an emerging epigenetic marker for cancer diagnosis.
Jianming Shao, Eric H. Bernicker, Chuan He, Zejuan Li   +3 more
doaj   +1 more source

Integrated single-cell sequencing of 5-hydroxymethylcytosine and genomic DNA using scH&G-seq

STAR Protocols, 2021
Summary: The asymmetric distribution of 5-hydroxymethylcytosine (5hmC) between two DNA strands of a chromosome enables endogenous reconstruction of cellular lineages at an individual-cell-division resolution. Further, when integrated with data on genomic
Alex Chialastri, Chatarin Wangsanuwat, Siddharth S. Dey   +2 more
doaj   +1 more source

5-Hydroxymethylcytosine Is Not Present in Appreciable Quantities in Arabidopsis DNA [PDF]

, 2014
5-Hydroxymethylcytosine (5-hmC) is an intermediate in active demethylation in metazoans, as well as a potentially stable epigenetic mark. Previous reports investigating 5-hydroxymethylcytosine in plants have reached conflicting conclusions.
Clish, Clary, Erdmann, Robert Michael, Gehring, Mary, Souza, Amanda L.   +3 more
core   +1 more source