Results 21 to 30 of about 9,742 (128)
Tissue-specific 5-hydroxymethylcytosine landscape of the human genome
Nature Communications, 2021 Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues and found 5hmC shows tissue-
Bo He +11 more
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Prediction of RNA 5-Hydroxymethylcytosine Modifications Using Deep Learning
IEEE Access, 2021 It is becoming increasingly clear that RNA 5-hydroxymethylcytosine (5hmC), which plays an important role in several biological processes, is one of the most important objects of study in the field of RNA epigenetics. Biochemical experiments using various
Syed Danish Ali +3 more
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Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
Nature Communications, 2017 Transcription activator-like effector proteins recognise specific DNA sequences via tandem repeats. Here the authors demonstrate TALEs can recognise the methylated bases 5mC and 5hmC, enabling them to detect epigenetic modifications.
Yuan Zhang +7 more
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Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells.
PLoS ONE, 2013 Hydroxymethylcytosine in the genome is reported to be an intermediate of demethylation. In the present study, we demonstrated that maintenance methyltransferase Dnmt1 scarcely catalyzed hemi-hydroxymethylated DNA and that the hemi-hydroxymethylated DNA ...
Junji Otani +9 more
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Aberrant gene-specific DNA methylation signature analysis in cervical cancer
Tumor Biology, 2017 Multicomponent molecular modifications such as DNA methylation may offer sensitive and specific cervical intraepithelial neoplasia and cervical cancer biomarkers.
Samatha Bhat +8 more
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High-throughput sequencing offers new insights into 5-hydroxymethylcytosine
Biomolecular Concepts, 2016 Chemical modifications of DNA comprise epigenetic mechanisms that contribute to the maintenance of cellular activities and memory. Although the function of 5-methylcytosine (5-mC) has been extensively studied, little is known about the function(s) of ...
Pang Alina P.S. +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Epigenetics, 2019 The placenta is an important organ in pregnancy, however, very little is understood about placental development at a molecular level. This includes the role of epigenetic mechanisms and how they change throughout gestation.
Rebecca L. Wilson +7 more
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Epigenetics, 2023 Background: Elucidating epigenetic mechanisms could provide new biomarkers for disease diagnosis and prognosis. Technological advances allow genome-wide profiling of 5-hydroxymethylcytosines (5hmC) in liquid biopsies.
Lu Gao +7 more
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