Results 41 to 50 of about 16,942 (208)

5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma [PDF]

Clinical Epigenetics, 2016
Primary hyperparathyroidism is characterized by enlarged parathyroid glands due to an adenoma (80-85 %) or multiglandular disease (~15 %) causing hypersecretion of parathyroid hormone (PTH) and generally hypercalcemia. Parathyroid cancer is rare (
Barazeghi, E, Gill, AJ, Sidhu, S, Norlen, O, Dina, R, Palazzo, FF, Hellman, P, Stalberg, P, Westin, G   +8 more
openaire   +5 more sources

Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition

Nature Communications, 2017
Transcription activator-like effector proteins recognise specific DNA sequences via tandem repeats. Here the authors demonstrate TALEs can recognise the methylated bases 5mC and 5hmC, enabling them to detect epigenetic modifications.
Yuan Zhang, Lulu Liu, Shengjie Guo, Jinghui Song, Chenxu Zhu, Zongwei Yue, Wensheng Wei, Chengqi Yi   +7 more
doaj   +1 more source

Altering 5-hydroxymethylcytosine modification impacts ischemic brain injury [PDF]

Human Molecular Genetics, 2015
Epigenetic modifications such as cytosine methylation and histone modification are linked to the pathology of ischemic brain injury. Recent research has implicated 5-hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC) via oxidation by ten-eleven translocation (Tet) enzymes, in DNA methylation-related plasticity.
Zhigang, Miao, Yuquan, He, Ning, Xin, Miao, Sun, Li, Chen, Li, Lin, Jizhen, Li, Jiming, Kong, Peng, Jin, Xingshun, Xu   +9 more
openaire   +2 more sources

Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells.

PLoS ONE, 2013
Hydroxymethylcytosine in the genome is reported to be an intermediate of demethylation. In the present study, we demonstrated that maintenance methyltransferase Dnmt1 scarcely catalyzed hemi-hydroxymethylated DNA and that the hemi-hydroxymethylated DNA ...
Junji Otani, Hironobu Kimura, Jafar Sharif, Takaho A Endo, Yuichi Mishima, Toru Kawakami, Haruhiko Koseki, Masahiro Shirakawa, Isao Suetake, Shoji Tajima   +9 more
doaj   +1 more source

Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1-dependent mechanism [PDF]

, 2018
In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes.
Billi, Monia, Cannarile, Lorenza, Ceccarelli, Veronica, Grignani, Francesco, Ottini, Laura, Riccardi, Carlo, Ronchetti, Simona, Talesa, Vincenzo Nicola, Valentini, Virginia, Vecchini, Alba   +9 more
core   +1 more source

Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA [PDF]

Journal of the American Chemical Society, 2014
Oxidation of 5-methylcytosine in DNA by ten-eleven translocation (Tet) family of enzymes has been demonstrated to play a significant role in epigenetic regulation in mammals. We found that Tet enzymes also possess the activity of catalyzing the formation of 5-hydroxymethylcytidine (5-hmrC) in RNA in vitro.
Fu, Lijuan, Guerrero, Candace R., Zhong, Na, Amato, Nicholas J., Liu, Yunhua, Liu, Shuo, Cai, Qian, Ji, Debin, Jin, Seung-Gi, Niedernhofer, Laura J., Pfeifer, Gerd P., Xu, Guo-Liang, Wang, Yinsheng   +12 more
openaire   +2 more sources

Aberrant gene-specific DNA methylation signature analysis in cervical cancer

Tumor Biology, 2017
Multicomponent molecular modifications such as DNA methylation may offer sensitive and specific cervical intraepithelial neoplasia and cervical cancer biomarkers.
Samatha Bhat, Shama Prasada Kabekkodu, Vinay Koshy Varghese, Sanjiban Chakrabarty, Sandeep P Mallya, Harish Rotti, Deeksha Pandey, Pralhad Kushtagi, Kapaettu Satyamoorthy   +8 more
doaj   +1 more source

Direct Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease. [PDF]

Adv Sci (Weinh)
Alzheimer's disease (AD) is associated with genetic risk factors and widespread epigenetic alterations. 5‐Hydroxymethylcytosine (5hmC), an oxidized derivative of 5‐methylcytosine (5mC), constitutes up to 20% of 5mC in neuronal DNA and is implicated in ...
Wang ZX, Chen F, He BD, Wang FC, Cha J, Song Y, Meng WY, Zou WY, Fu YT, Sun SX, Sun ZY, Jiang HM, Zhao KY, Hou Y, Shi J, Xue JH.   +15 more
europepmc   +2 more sources

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

High-throughput sequencing offers new insights into 5-hydroxymethylcytosine

Biomolecular Concepts, 2016
Chemical modifications of DNA comprise epigenetic mechanisms that contribute to the maintenance of cellular activities and memory. Although the function of 5-methylcytosine (5-mC) has been extensively studied, little is known about the function(s) of ...
Pang Alina P.S., Sugai Christopher, Maunakea Alika K.   +2 more
doaj   +1 more source