Results 41 to 50 of about 9,742 (128)

Induction of Radiata Pine Somatic Embryogenesis at High Temperatures Provokes a Long-Term Decrease in DNA Methylation/Hydroxymethylation and Differential Expression of Stress-Related Genes

Plants, 2020
Based on the hypothesis that embryo development is a crucial stage for the formation of stable epigenetic marks that could modulate the behaviour of the resulting plants, in this study, radiata pine somatic embryogenesis was induced at high temperatures (
Ander Castander-Olarieta, Cátia Pereira, Ester Sales, Mónica Meijón, Isabel Arrillaga, María Jesús Cañal, Tomás Goicoa, María Dolores Ugarte, Paloma Moncaleán, Itziar A. Montalbán   +9 more
doaj   +1 more source

Tet proteins: on track towards DNA demethylation?

Biomolecular Concepts, 2012
Dynamic DNA methylation is a prerequisite for many developmental processes and maintenance of cellular integrity. In mammals however, mechanisms of active DNA demethylation have for long been elusive.
Véron Nathalie
doaj   +1 more source

Oncogenic BRAF and KRAS Promote Global DNA Hypomethylation Through a Directed Pathway That Upregulates TET3

Cancer Science, EarlyView.
Oncogenic BRAF and KRAS promote global DNA hypomethylation through a directed pathway that increases the levels of TET3, which helps drive tumorigenesis. ABSTRACT Aberrant epigenetic modification is one of the characteristics of the cancer genome.
Ichiro Onoyama, W. Rod Hardy, Shoichiro Takeishi, Lihua Julie Zhu, Yanglan Tan, Lloyd Hutchinson, Jianhong Ou, Leyuan Ma, Ching‐Man Virbasius, Masafumi Yasunaga, Keiichi I. Nakayama, Scott A. Shaffer, Michael R. Green   +12 more
wiley   +1 more source

The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases

Frontiers in Neuroscience, 2014
DNA methylation primarily occurs within human cells as a 5-methylcytosine (5mC) modification of the cytosine bases in CpG dinucleotides. 5mC has proven to be an important epigenetic mark that is involved in the control of gene transcription for processes
Sahar eAl-Mahdawi, Sahar eAl-Mahdawi, Sara eAnjomani Virmouni, Sara eAnjomani Virmouni, Mark Adrian Pook, Mark Adrian Pook   +5 more
doaj   +1 more source

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

European Journal of Haematology, EarlyView.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco, Diane S. Krause, Sara T. Olalla Saad   +2 more
wiley   +1 more source

Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer

Clinical Epigenetics, 2018
Background 5-Hydroxymethylcytosine (5hmC) is converted from 5-methylcytosine (5mC) by a group of enzymes termed ten-eleven translocation (TET) family dioxygenases.
Ding Peng, Guangzhe Ge, Yanqing Gong, Yonghao Zhan, Shiming He, Bao Guan, Yifan Li, Ziying Xu, Han Hao, Zhisong He, Gengyan Xiong, Cuijian Zhang, Yue Shi, Yuanyuan Zhou, Weimin Ci, Xuesong Li, Liqun Zhou   +16 more
doaj   +1 more source

TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation

Epigenetics & Chromatin, 2022
Background Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to its role in base excision repair. Recent evidence indicates a direct influence of PARP-
Anja Tolić, Mirunalini Ravichandran, Jovana Rajić, Marija Đorđević, Miloš Đorđević, Svetlana Dinić, Nevena Grdović, Jelena Arambašić Jovanović, Mirjana Mihailović, Nataša Nestorović, Tomasz P. Jurkowski, Aleksandra S. Uskoković, Melita S. Vidaković   +12 more
doaj   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Contribution of One‐Electron Oxidation of Purine and Pyrimidine Bases to the Photo‐ and Radiation‐Induced Damage to Cellular DNA

ChemPhysChem, Volume 27, Issue 15, 14 August 2026.
One‐electron oxidation of purine and pyrimidine bases of isolated and cellular DNA generates related reactive base radical cations that are converted into final decomposition products through deprotonation and hydration. In the case of guanine, the most susceptible nucleobase to one‐electron oxidants, 8‐hydroxy‐7,8‐dihydroguanyl radical, thus formed by
Jean Cadet, Dimitar Angelov, Paolo DI Mascio, J. Richard Wagner   +3 more
wiley   +1 more source

Application of the High-Throughput TAB-Array for the Discovery of Novel 5-Hydroxymethylcytosine Biomarkers in Pancreatic Ductal Adenocarcinoma

Epigenomes, 2019
The clinical outcomes of pancreatic ductal adenocarcinoma (PDAC) remain dismal, with an estimated five-year survival rate of less than 5%. Early detection and prognostic approaches, including robust biomarkers for PDAC, are critical for improving patient
Chang Zeng, Zhou Zhang, Jun Wang, Brian C-H Chiu, Lifang Hou, Wei Zhang   +5 more
doaj   +1 more source