Results 41 to 50 of about 8,428,479 (200)

Prediction of RNA 5-Hydroxymethylcytosine Modifications Using Deep Learning

IEEE Access, 2021
It is becoming increasingly clear that RNA 5-hydroxymethylcytosine (5hmC), which plays an important role in several biological processes, is one of the most important objects of study in the field of RNA epigenetics. Biochemical experiments using various
Syed Danish Ali, Jee Hong Kim, Hilal Tayara, Kil to Chong   +3 more
doaj   +1 more source

Tet-Mediated Formation of 5-Hydroxymethylcytosine in RNA [PDF]

Journal of the American Chemical Society, 2014
Oxidation of 5-methylcytosine in DNA by ten-eleven translocation (Tet) family of enzymes has been demonstrated to play a significant role in epigenetic regulation in mammals. We found that Tet enzymes also possess the activity of catalyzing the formation of 5-hydroxymethylcytidine (5-hmrC) in RNA in vitro.
Fu, Lijuan, Guerrero, Candace R., Zhong, Na, Amato, Nicholas J., Liu, Yunhua, Liu, Shuo, Cai, Qian, Ji, Debin, Jin, Seung-Gi, Niedernhofer, Laura J., Pfeifer, Gerd P., Xu, Guo-Liang, Wang, Yinsheng   +12 more
openaire   +2 more sources

Cell cycle-dependent turnover of 5-hydroxymethyl cytosine in mouse embryonic stem cells.

PLoS ONE, 2013
Hydroxymethylcytosine in the genome is reported to be an intermediate of demethylation. In the present study, we demonstrated that maintenance methyltransferase Dnmt1 scarcely catalyzed hemi-hydroxymethylated DNA and that the hemi-hydroxymethylated DNA ...
Junji Otani, Hironobu Kimura, Jafar Sharif, Takaho A Endo, Yuichi Mishima, Toru Kawakami, Haruhiko Koseki, Masahiro Shirakawa, Isao Suetake, Shoji Tajima   +9 more
doaj   +1 more source

5-Hydroxymethylcytosine is a predominantly stable DNA modification [PDF]

Nature Chemistry, 2014
5-Hydroxymethylcytosine (hmC) is an oxidation product of 5-methylcytosine which is present in the deoxyribonucleic acid (DNA) of most mammalian cells. Reduction of hmC levels in DNA is a hallmark of cancers. Elucidating the dynamics of this oxidation reaction and the lifetime of hmC in DNA is fundamental to understanding hmC function.
Bachman, Martin, Uribe-Lewis, Santiago, Yang, Xiaoping, Williams, Michael, Murrell, Adele, Balasubramanian, Shankar   +5 more
openaire   +2 more sources

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma [PDF]

Cell, 2012
DNA methylation at the 5 position of cytosine (5-mC) is a key epigenetic mark that is critical for various biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the ten-eleven translocation (TET) family of DNA hydroxylases.
Lian, Christine Guo, Xu, Yufei, Ceol, Craig, Wu, Feizhen, Larson, Allison, Dresser, Karen, Xu, Wenqi, Tan, Li, Hu, Yeguang, Zhan, Qian, Lee, Chung-wei, Hu, Di, Lian, Bill Q., Kleffel, Sonja, Yang, Yijun, Neiswender, James, Khorasani, Abraham J., Fang, Rui, Lezcano, Cecilia, Duncan, Lyn M., Scolyer, Richard A., Thompson, John F., Kakavand, Hojabr, Houvras, Yariv, Zon, Leonard I., Mihm, Martin C., Kaiser, Ursula B., Schatton, Tobias, Woda, Bruce A., Murphy, George F., Shi, Yujiang G.   +30 more
openaire   +2 more sources

Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. [PDF]

, 2014
Epigenetic processes play a key role in the central nervous system and altered levels of 5-methylcytosine have been associated with a number of neurologic phenotypes, including Alzheimer's disease (AD).
Daniel Condliffe (21996824), C Fernandes (4048552), C Troakes (21824105), Katie Lunnon (133938), A Wong (3550217), P Proitsi (7719863), Simon Lovestone (84515), J Cooper (5348693), Y Patel (13485838), J Mill (17767260), L Chouliaras (21997037), Leonard Schalkwyk (524709)   +11 more
core   +2 more sources

Aberrant gene-specific DNA methylation signature analysis in cervical cancer

Tumor Biology, 2017
Multicomponent molecular modifications such as DNA methylation may offer sensitive and specific cervical intraepithelial neoplasia and cervical cancer biomarkers.
Samatha Bhat, Shama Prasada Kabekkodu, Vinay Koshy Varghese, Sanjiban Chakrabarty, Sandeep P Mallya, Harish Rotti, Deeksha Pandey, Pralhad Kushtagi, Kapaettu Satyamoorthy   +8 more
doaj   +1 more source

High-throughput sequencing offers new insights into 5-hydroxymethylcytosine

Biomolecular Concepts, 2016
Chemical modifications of DNA comprise epigenetic mechanisms that contribute to the maintenance of cellular activities and memory. Although the function of 5-methylcytosine (5-mC) has been extensively studied, little is known about the function(s) of ...
Pang Alina P.S., Sugai Christopher, Maunakea Alika K.   +2 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination

, 2014
5-hydroxymethylcytosine (5hmC) has been suggested to be involved in various nucleic acid transactions and cellular processes, including transcriptional regulation, demethylation of 5-methylcytosine and stem cell pluripotency.
Klungland, Arne, Robertson, Adam B., Robertson, Julia, Fusser, Markus   +3 more
core   +1 more source