Results 61 to 70 of about 9,742 (128)

Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics

Beilstein Journal of Organic Chemistry, 2014
In this work we present for the first time the synthesis of novel 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) derivatives that can be used as tools in the emerging field of epigenetics for deciphering chemical biology of TET-mediated ...
Anna Chentsova, Era Kapourani, Athanassios Giannis   +2 more
doaj   +1 more source

Epigenetic Regulations in Neural Stem Cells and Neurological Diseases

Stem Cells International, 2018
Among the regulatory mechanisms of the renewal and differentiation of neural stem cells, recent evidences support that epigenetic modifications such as DNA methylation, histone modification, and noncoding RNAs play critical roles in the regulation on the
Hang Zhou, Bin Wang, Hao Sun, Xingshun Xu, Yongxiang Wang   +4 more
doaj   +1 more source

Ten-eleven Translocation-2 Regulates DNA Hydroxymethylation Status and Psoriasiform Dermatitis Progression in Mice

Acta Dermato-Venereologica, 2018
Epigenetics plays an important role in the development and progression of many diseases. There is increasing evidence for the importance of epigenetic modifications in the progression of psoriasis.
Xin Wang, Xinxin Liu, Xiaoru Duan, Ke Zhu, Song Zhang, Lu Gan, Nian Liu, Himanshu Jaypaul, Johanna T. Makamure, Zhangyin Ming, Hongxiang Chen   +10 more
doaj   +1 more source

5'-Methylcytosine and 5'-hydroxymethylcytosine each provide epigenetic information to the mouse zygote.

PLoS ONE, 2013
Covalent modification of cytosine nucleotides within the genome encode essential epigenetic information, with methylation (5meC) and hydroxymethylation (5hmC) having received most attention.
Yan Li, Chris O'Neill
doaj   +1 more source

Comprehensive mapping of 5-hydroxymethylcytosine epigenetic dynamics in axon regeneration

Epigenetics, 2017
In contrast to central nervous system neurons, dorsal root ganglia (DRG) neurons can switch to a regenerative state after peripheral axotomy. In a screen for chromatin regulators of the regenerative responses in this conditioning lesion paradigm, we ...
Yong-Hwee Eddie Loh, Andrew Koemeter-Cox, Mattéa J. Finelli, Li Shen, Roland H. Friedel, Hongyan Zou   +5 more
doaj   +1 more source

Early-life stress links 5-hydroxymethylcytosine to anxiety-related behaviors

Epigenetics, 2017
Environmental stress contributes to the development of psychiatric disorders, including posttraumatic stress disorder and anxiety. While even acute stress alters gene expression, the molecular mechanisms underlying these changes remain largely unknown. 5-
Ligia A. Papale, Andy Madrid, Sisi Li, Reid S. Alisch   +3 more
doaj   +1 more source

Cell-Free DNA 5-Hydroxymethylcytosine Signatures for Lung Cancer Prognosis

Cells
Accurate prognostic markers are essential for guiding effective lung cancer treatment strategies. The level of 5-hydroxymethylcytosine (5hmC) in tissue is independently associated with overall survival (OS) in lung cancer patients.
Jianming Shao, Randall J. Olsen, Saro Kasparian, Chuan He, Eric H. Bernicker, Zejuan Li   +5 more
doaj   +1 more source

HM-DyadCap - capture and mapping of 5-hydroxymethylcytosine/5-methylcytosine CpG dyads in mammalian DNA. [PDF]

Nucleic Acids Res
Engelhard L, Schiller D, Zambrano-Mila MS, Keliuotyte K, Buchmuller B, Tiwari S, Imig J, Simeone A, Schröter C, Becker S, Summerer D.   +10 more
europepmc   +2 more sources

Editorial: Beyond CpG Methylation: New Modifications in Eukaryotic DNA

Frontiers in Cell and Developmental Biology, 2018
Reinhard Stöger, Alexey Ruzov
doaj   +1 more source

5-hydroxymethylcytosine signatures of tissue as potential predictive markers for platinum resistance in epithelial ovarian cancer patients. [PDF]

Sci Rep
Xue Y, Yi Z, Yu P, Huang C, Li H, Zheng M, Yang Z, Xu S, Guo H, Chen L, Lin J, Zhao L.   +11 more
europepmc   +1 more source