Results 61 to 70 of about 16,942 (208)

Methyltransferase‐Directed Derivatization of 5‐Hydroxymethylcytosine in DNA [PDF]

Angewandte Chemie International Edition, 2011
Cytosine modification by AdoMet–dependent DNA methyltransferases is part of an epigenetic regulatory network in vertebrates. Here we show that, in the absence of AdoMet, bacterial cytosine-5 methyltransferases can catalyze condensation of aliphatic thiols and selenols to 5-hydroxymethylcytosine in DNA yielding 5-chalcogenomethyl derivatives.
Zita, Liutkevičiūtė, Edita, Kriukienė, Indrė, Grigaitytė, Viktoras, Masevičius, Saulius, Klimašauskas   +4 more
openaire   +2 more sources

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

European Journal of Haematology, EarlyView.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco, Diane S. Krause, Sara T. Olalla Saad   +2 more
wiley   +1 more source

Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.

PLoS ONE, 2013
During mammalian development the fertilized zygote and primordial germ cells lose their DNA methylation within one cell cycle leading to the concept of active DNA demethylation.
Daniel Nettersheim, Lukas C Heukamp, Florian Fronhoffs, Marc J Grewe, Natalie Haas, Anke Waha, Friedemann Honecker, Andreas Waha, Glen Kristiansen, Hubert Schorle   +9 more
doaj   +1 more source

Salivary Microvesicle Methylome and Microbiome Profiles in Periodontitis: An Exploratory Study

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim Salivary microvesicles (MVs) are nanosized extracellular vesicles from the host and microbiota whose cargo may mirror the biological state of their parent cells. This cross‐sectional study aimed to explore the diagnostic power of host methylome and microbiome profiles of MVs in various periodontal disease states. Materials and Methods This
Pingping Han, Chaminda Seneviratne, Qiongyi Zhao, Carlos Salomon, Xiang Li, Sašo Ivanovski   +5 more
wiley   +1 more source

Selective Capture of 5-hydroxymethylcytosine from Genomic DNA [PDF]

Journal of Visualized Experiments, 2012
5-methylcytosine (5-mC) constitutes ~2-8% of the total cytosines in human genomic DNA and impacts a broad range of biological functions, including gene expression, maintenance of genome integrity, parental imprinting, X-chromosome inactivation, regulation of development, aging, and cancer(1).
Yujing, Li, Chun-Xiao, Song, Chuan, He, Peng, Jin   +3 more
openaire   +2 more sources

Regulation and Functional Significance of 5-Hydroxymethylcytosine in Cancer

Epigenomes, 2017
Epigenetic modes of gene regulation are important for physiological conditions and its aberrant changes can lead to disease like cancer. 5-hydroxymethylcytosine (5hmC) is an oxidized form of 5-methylcytosine (5mC) catalyzed by Ten Eleven Translocation ...
Vittal Rangan Arvinden, Arunagiri Kuha Deva Magendhra Rao, Thangarajan Rajkumar, Samson Mani   +3 more
doaj   +1 more source

Exaggerated CpH methylation in the autism-affected brain. [PDF]

, 2017
BackgroundThe etiology of autism, a complex, heritable, neurodevelopmental disorder, remains largely unexplained. Given the unexplained risk and recent evidence supporting a role for epigenetic mechanisms in the development of autism, we explored the ...
Arking, Dan E, Ellis, Shannon E, Gupta, Simone, Moes, Anna, West, Andrew B   +4 more
core   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain.

PLoS ONE, 2011
Recent discovery of 5-hydroxymethylcytosine (5hmC) in genomic DNA raises the question how this sixth base is recognized by cellular proteins. In contrast to the methyl-CpG binding domain (MBD) of MeCP2, we found that the SRA domain of Uhrf1, an essential
Carina Frauer, Thomas Hoffmann, Sebastian Bultmann, Valentina Casa, M Cristina Cardoso, Iris Antes, Heinrich Leonhardt   +6 more
doaj   +1 more source