Results 81 to 90 of about 8,428,479 (200)

Application of the High-Throughput TAB-Array for the Discovery of Novel 5-Hydroxymethylcytosine Biomarkers in Pancreatic Ductal Adenocarcinoma

Epigenomes, 2019
The clinical outcomes of pancreatic ductal adenocarcinoma (PDAC) remain dismal, with an estimated five-year survival rate of less than 5%. Early detection and prognostic approaches, including robust biomarkers for PDAC, are critical for improving patient
Chang Zeng, Zhou Zhang, Jun Wang, Brian C-H Chiu, Lifang Hou, Wei Zhang   +5 more
doaj   +1 more source

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, Volume 11, Issue 12, 18 June 2026.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Epigenetically driven impairment of BDNF–ARC signaling contributes to circadian and cognitive disarray in a mouse model of postoperative delirium

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Postoperative delirium (POD) is common in older surgical patients and is clinically associated with an increased risk of long‐term cognitive decline and dementia; disrupted BDNF signaling and circadian dysregulation are implicated, but their coordinated mechanisms remain unclear.
Hari Prasad Osuru, Navya Atluri, Tam Le, Jinny Park, Michal Jedrusiak, Elzbieta Dulko, Meghana Illendula, Nadia Lunardi   +7 more
wiley   +1 more source

Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine.

, 2016
The reprogramming of cellular memory in specific cell types, and in visceral adipocytes in particular, appears to be a fundamental aspect of obesity and its related negative health outcomes.
Ping Yu (215536), Suresh Ambati (3170865), Lexiang Ji, Suresh Ambati, Miao Yu, Crystal Jackson (3170868), Chuan He, Robert J Schmitz, Robert J. Schmitz (227029), Elizabeth C McKinney, Richard B Meagher, Richard B. Meagher (840914), Lexiang Ji (615409), Chuan He (178952), Crystal Jackson, Elizabeth C. McKinney (3170871), Ping Yu, Clifton A Baile, Kevin J. Lee (3170862), Clifton A. Baile (217075), Kevin J Lee, Miao Yu (199182)   +21 more
core   +1 more source

5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes [PDF]

, 2013
Background: Cytosine methylation is a frequent epigenetic modification restricting the activity of gene regulatory elements. Whereas DNA methylation patterns are generally inherited during replication, both embryonic and somatic differentiation processes
Andreesen, Reinhard, Maja Klug, Schmidhofer, Sandra, Reinhard Andreesen, Klug, Maja, Claudia Gebhard, Michael Rehli, Rehli, Michael, Sandra Schmidhofer, Gebhard, Claudia   +9 more
core   +1 more source

Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter

Nature Communications, 2018
Tet-mediated DNA oxidation converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), which is essential to regulate different biological processes.
Ruili Yang, Tingting Yu, Xiaoxing Kou, Xiang Gao, Chider Chen, Dawei Liu, Yanheng Zhou, Songtao Shi   +7 more
doaj   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, Volume 73, Issue 3, Page 1137-1150, June 2026.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Efficient Synthesis of 5-Hydroxymethylcytosine Containing DNA

, 2016
5-Hydroxymethylcytosine (5-HOMedC) was recently discovered as the sixth base in the mammalian genome. The development of a new phosphoramidite building block is reported, which allows efficient synthesis of 5-HOMedC containing DNA.
Martin Münzel (1485277), Daniel Globisch (234368), Thomas Carell (199465), Christian Trindler (2243335)   +3 more
core   +1 more source

The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression

, 2011
5-Hydroxymethylcytosine (5hmC) was recently described as a stable modification in mammalian DNA. 5hmC is formed by the enzymatic oxidation of 5-methylcytosine (5meC).
Klungland, Arne, Julia Robertson, Robertson, Adam B., Adam B. Robertson, Robertson, Julia, Arne Klungland   +5 more
core   +1 more source

Epigenetic Aging in Brain Tissue of the Self‐Fertilizing Vertebrate, Kryptolebias marmoratus

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Using the self‐fertilizing vertebrate Kryptolebias marmoratus, we developed an epigenetic clock from brain tissue that predicts chronological age with high accuracy, demonstrating that DNA methylation changes consistently with age even in the near absence of genetic variation. The 40 age‐associated CpG sites identified map to genes with conserved roles
Justine Bélik, Frédéric Silvestre
wiley   +1 more source