Results 81 to 90 of about 16,942 (208)

The role of 5-hydroxymethylcytosine in human cancer [PDF]

Cell and Tissue Research, 2014
The patterns of DNA methylation in human cancer cells are highly abnormal and often involve the acquisition of DNA hypermethylation at hundreds or thousands of CpG islands that are usually unmethylated in normal tissues. The recent discovery of 5-hydroxymethylcytosine (5hmC) as an enzymatic oxidation product of 5-methylcytosine (5mC) has led to models ...
Gerd P, Pfeifer, Wenying, Xiong, Maria A, Hahn, Seung-Gi, Jin   +3 more
openaire   +2 more sources

TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation

Epigenetics & Chromatin, 2022
Background Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to its role in base excision repair. Recent evidence indicates a direct influence of PARP-
Anja Tolić, Mirunalini Ravichandran, Jovana Rajić, Marija Đorđević, Miloš Đorđević, Svetlana Dinić, Nevena Grdović, Jelena Arambašić Jovanović, Mirjana Mihailović, Nataša Nestorović, Tomasz P. Jurkowski, Aleksandra S. Uskoković, Melita S. Vidaković   +12 more
doaj   +1 more source

Discovery and Evaluation of Cadmium‐Adapted Daphnia pulex Genotypes in a Region of Historical Mining Reveals Adaptation Protects the Germline From Cadmium‐Induced Mutations

Molecular Ecology, Volume 35, Issue 9, May 2026.
ABSTRACT Exposure to chemical pollutants can alter the rate and genome‐wide distribution of germline mutations. However, studies measuring the effects of chemical exposure on mutation rates and spectra have not considered the ecological and evolutionary backgrounds of the studied genotypes, which could influence the rates and patterns of germline ...
Nathan Keith, Stephen P. Glaholt, Craig E. Jackson, Kim Young, Karel De Schamphelaere, John K. Colbourne, Joseph R. Shaw   +6 more
wiley   +1 more source

5-hydroxymethylcytosine is a key epigenetic regulator of keratinocyte stem cells during psoriasis pathogenesis [PDF]

, 2019
Epigenetic regulation is now known to play an important role in determining stem cell fate during normal tissue development and disease pathogenesis. In this study, we report loss of 5-hydroxymethylcytosine (5-hmC) mediated by ten-eleven translocation ...
Yuan, Christine Wan-Yin
core  

Circulating Microbial Metabolites Predict Tumor Relapse and Chemotherapy Efficacy in Nasopharyngeal Carcinoma

MedComm, Volume 7, Issue 4, April 2026.
ABSTRACT The value of microbial metabolites in prognosis and treatment response prediction in patients with nasopharyngeal carcinoma (NPC) remains unclear. Here, through the untargeted metabolomic analysis of plasma in 48 paired NPC patients with or without tumor relapse, we identified distinct circulating metabolite atlases between NPC patients with ...
Jun‐Yan Li, Yao Yao, Xi‐Rong Tan, Nan Si, Wei Jiang, Ying‐Qi Lu, Jia‐Hao Dai, Tian‐Tian Yu, Hao‐Cheng Hu, Yu‐Fei Duan, Sen‐Yu Feng, Sai‐Wei Huang, Ye‐Lin Liang, Sha Gong, Na Liu, Yu‐Min Hu, Ying‐Qing Li   +16 more
wiley   +1 more source

Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer

Clinical Epigenetics, 2018
Background 5-Hydroxymethylcytosine (5hmC) is converted from 5-methylcytosine (5mC) by a group of enzymes termed ten-eleven translocation (TET) family dioxygenases.
Ding Peng, Guangzhe Ge, Yanqing Gong, Yonghao Zhan, Shiming He, Bao Guan, Yifan Li, Ziying Xu, Han Hao, Zhisong He, Gengyan Xiong, Cuijian Zhang, Yue Shi, Yuanyuan Zhou, Weimin Ci, Xuesong Li, Liqun Zhou   +16 more
doaj   +1 more source

Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences [PDF]

, 2016
DNA methylation is the best known epigenetic mark. Cancer and other pathologies show an altered DNA methylome. However, delivering complete DNA methylation maps is compromised by the price and labor-intensive interpretation of single nucleotide methods ...
Arribas, Carles, Esteller, Manel, Moran, Sebastian   +2 more
core   +1 more source

Osteoarthritis: Epidemiology, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen, Wenlong Chen, Tianpeng Xu, Hong Wang, Yuheng Zhang, Li Wang, Sijie Zhu, Huaqiang Tao, Xing Yang   +8 more
wiley   +1 more source

Exploration of hydroxymethylation in Kagami-Ogata syndrome caused by hypermethylation of imprinting control regions [PDF]

, 2015
Primer sequences utilized in BS/oxBS pyrosequencing and cloning-based sequencing.
Kazuhiko Nakabayashi, Kazuki Yamazawa, Keiko Matsubara, Kenichiro Hata, Maki Fukami, Masayo Kagami, Tsutomu Ogata   +6 more
core   +2 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source