Results 91 to 100 of about 16,942 (208)

5-hydroxymethylcytosine DNA glycosylase activity in mammalian tissue

Biochemical and Biophysical Research Communications, 1988
The enzymatic release of 5-hydroxymethylcytosine from T2 bacteriophage DNA was effected by an extract of calf thymus. Like the previously described 5-hydroxymethyluracil DNA glycosylase, 5-hydroxymethylcytosine DNA glycosylase was not detectable in bacterial extracts.
S V, Cannon, A, Cummings, G W, Teebor
openaire   +2 more sources

Application of the High-Throughput TAB-Array for the Discovery of Novel 5-Hydroxymethylcytosine Biomarkers in Pancreatic Ductal Adenocarcinoma

Epigenomes, 2019
The clinical outcomes of pancreatic ductal adenocarcinoma (PDAC) remain dismal, with an estimated five-year survival rate of less than 5%. Early detection and prognostic approaches, including robust biomarkers for PDAC, are critical for improving patient
Chang Zeng, Zhou Zhang, Jun Wang, Brian C-H Chiu, Lifang Hou, Wei Zhang   +5 more
doaj   +1 more source

A lexicon of DNA modifications: their roles in embryo development and the germline [PDF]

, 2018
5-methylcytosine (5mC) on CpG dinucleotides has been viewed as the major epigenetic modification in eukaryotes for a long time. Apart from 5mC, additional DNA modifications have been discovered in eukaryotic genomes.
Amouroux, Aran, Arand, Arand, Aravind, Auclair, Bachman, Bachman, Bai, Bakhtari, Barrès, Basanta-Sanchez, Baubec, Bird, Bird, Bjelland, Blackburn, Booth, Borgel, Branco, Branco, Brasa, Breiling, Budzko, Canovas, Cao, Capuano, Cedar, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chistiakov, Choi, Church, Chuva de Sousa Lopes, Cimmino, Cortellino, Cortázar, Cui, Dai, Dawlaty, Dawlaty, Deplus, Dias, Ding, Dobbs, Donkin, Edwards, Eguizabal, Esanov, Esteller, Feng, Ficz, Ficz, Fidalgo, Fischer, Fleming, Forterre, Franklin, Frauer, Fu, Gabel, Gackowski, Gao, Gao, Gapp, Gapp, Gassen, Greer, Gross, Gu, Guenatri, Guo, Guo, Guo, Guo, Guo, Guo, Hackett, Hahn, Hainer, Han, Hardwick, Hargan-Calvopina, Hashimoto, He, He, He, Heras, Heyn, Hirasawa, Hnisz, Ho, Holland, Holliday, Holliday, Hon, Hon, Howell, Hu, Huang, Huang, Hudson, Huh, Hyldig, Ichiyanagi, Ideraabdullah, Inoue, Inoue, Iqbal, Ito, Ito, Ito, Iurlaro, Iurlaro, Iyer, Jafarpour, Jia, Jiang, Jones, Jurkowska, Kawasaki, Kellinger, Khoueiry, Kiani, Kim, Kinde, Klungland, Kobayashi, Kobayashi, Kobayashi, Kong, Koziol, Kweon, Laird, Law, Lee, Lee, Leenen, Lewis, Li, Li, Liang, Liao, Lin, Lister, Lister, Lister, Liu, Liu, Liu, Lu, Lu, Luo, Luo, López, Ma, Maatouk, Madrid, Magnani, Maiti, Marina, Masala, Maurano, Mayer, Mellén, Messer, Messerschmidt, Mondo, Monk, Mooijman, Nabel, Nakamura, Nakamura, Neri, Neri, Nestler, Nestor, Ngo, Ngo, Nilsson, Nordstrand, O'Brown, O'Neill, Okamoto, Okano, Olinski, Ooi, Oswald, Pan, Papale, Pastor, Patil, Peters, Petrussa, Petterson, Pfaffeneder, Pfaffeneder, Pfeifer, Piccolo, Pinney, Plongthongkum, Ponnaluri, Potok, Quenneville, Raiber, Ramsahoye, Rand, Rangam, Rasmussen, Ratnam, Reynolds, Rhoads, Riggs, Robertson, Robertson, Rodgers, Ronkainen, Rose, Ruzov, Sager, Salvaing, Sampath Kumar, Sarnacki, Sasaki, Schaefer, Schiffers, Schultz, Schuster, Seisenberger, Sharma, Shen, Shen, Shirane, Simpson, Skinner, Smith, Smith, Smith, Song, Song, Song, Sood, Sperlazza, Spruijt, Stadler, Strogantsev, Stroud, Stöger, Sun, Szulwach, Tan, Tang, Thakore, Thiaville, Tomizawa, Tseng, Tsukada, Tuorto, van Luenen, Vanyushin, Velasco, Vella, Vlachogiannis, von Meyenn, Vrachnis, Wahl, Wang, Wang, Wang, Wang, Wang, Watanabe, Watson, Williams, Wossidlo, Wu, Wu, Wu, Wu, Wu, Xu, Yamaguchi, Yamaguchi, Yamaguchi, Yang, Yildirim, Yu, Zaleski, Zeng, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhou, Zhu, Zhu, Ziller   +305 more
core   +3 more sources

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, Volume 101, Issue 2, Page 826-847, April 2026.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source

Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus

Genomics, 2014
Gene-environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-Hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for ~40% of modified cytosine in the brain and has been implicated in DNA methylation-related plasticity.
Irier, Hasan, Street, R. Craig, Dave, Ronak, Lin, Li, Cai, Catherine, Davis, Timothy Hayden, Yao, Bing, Cheng, Ying, Jin, Peng   +8 more
openaire   +2 more sources

Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter

Nature Communications, 2018
Tet-mediated DNA oxidation converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), which is essential to regulate different biological processes.
Ruili Yang, Tingting Yu, Xiaoxing Kou, Xiang Gao, Chider Chen, Dawei Liu, Yanheng Zhou, Songtao Shi   +7 more
doaj   +1 more source

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, Volume 59, Issue 4, April 2026.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients

Nature Communications, 2016
Glioblastomas have distorted epigenomes. Here, the authors compare the genome-wide profiles of 5-methylcytosine and 5- hydroxymethylcytosine in glioblastoma and prefrontal cortex tissue reporting a correlation between these profiles and patients ...
Kevin C. Johnson, E. Andres Houseman, Jessica E. King, Katharine M. von Herrmann, Camilo E. Fadul, Brock C. Christensen   +5 more
doaj   +1 more source

Medulloblastoma and ependymoma cells display levels of 5-carboxylcytosine and elevated TET1 expression [PDF]

, 2017
Background Alteration of DNA methylation (5-methylcytosine, 5mC) patterns represents one of the causes of tumorigenesis and cancer progression. Tet proteins can oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine and 5-carboxylcytosine (5caC)
A Maiti, AA Rawłuszko-Wieczorek, BK Wu, CG Lian, CH Hsu, CJ Chang, CR Goding, E Tamanaha, EB Bian, G Ficz, G Ficz, GE Keles, H Huang, H Takai, H Wu, JM Bont de, KH Chen, KW Pajtler, L Yu, LM Wheldon, M Bachman, M Bachman, M Ehrlich, M Eleftheriou, M Iurlaro, M Iurlaro, M Parker, M Tahiliani, MA Dawson, MC Haffner, MD Taylor, MD Taylor, MZ Wu, N Ichimura, PA Jones, PR Tempest, RA Johnson, RJ Vanner, S Dietl, S Ito, SG Jin, SJ Park, T Milde, T Milde, TF Kraus, V Hovestadt, V Ramaswamy, Y Kudo, YF He, YP Tian   +49 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, Volume 20, Issue 3, Page 588-610, March 2026.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source