Results 91 to 100 of about 8,428,479 (200)

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases [PDF]

, 2012
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood.
Julia Arand (155279), Meissner, A, Meilinger, D., Arand, Julia, Leonhardt, Heinrich, Jenuwein, Thomas, Wolf, Verena, Thomas Jenuwein (70681), Tommy Karius, David Spieler, Jenuwein, T., Xu, G, Tommy Karius (155285), Walter, Jörn, Wolf, V., Branco, MR, Leonhardt, H, Spieler, D, Branco, Miguel R., Meilinger, Daniela, Julia Arand, Jörn Walter, Walter, Joern, Jörn Walter (37094), Walter, J, Miguel R. Branco (42502), Verena Wolf, Karius, T, Meissner, Alexander, Arand, J, Alexander Meissner (11643), Meilinger, D, Daniela Meilinger, Heinrich Leonhardt (18589), Verena Wolf (155286), Daniela Meilinger (107843), Arand, J., Jenuwein, T, Miguel R Branco, Thomas Jenuwein, Guoliang Xu, Alexander Meissner, Walter, J., Meissner, A., Heinrich Leonhardt, Karius, Tommy, Guoliang Xu (67200), Spieler, David, Karius, T., Xu, Guoliang, David Spieler (155282), Branco, M., Xu, G., Wolf, V, Spieler, D., Leonhardt, H.   +55 more
core   +1 more source

Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs

Clinical Epigenetics, 2019
Background Accumulating evidence suggests that epigenetic changes play key roles in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the dynamic regulation of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in diabetic peripheral ...
Er-Feng Yuan, Ying Yang, Lin Cheng, Xujing Deng, Shao-Min Chen, Xin Zhou, Song-Mei Liu   +6 more
doaj   +1 more source

Profiling of oxBS-450K 5-hydroxymethylcytosine in human placenta and brain reveals enrichment at imprinted loci

Epigenetics, 2018
DNA methylation (5-methylcytosine, 5 mC) is involved in many cellular processes and is an epigenetic mechanism primarily associated with transcriptional repression.
Jose Ramon Hernandez Mora, Marta Sanchez-Delgado, Paolo Petazzi, Sebastian Moran, Manel Esteller, Isabel Iglesias-Platas, David Monk   +6 more
doaj   +1 more source

Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice

Cell Reports, 2018
Summary: 5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC and its writers, ten-eleven translocation (Tet) proteins, in stress-induced response have yet to be ...
Ying Cheng, Miao Sun, Li Chen, Yujing Li, Li Lin, Bing Yao, Ziyi Li, Zhiqin Wang, Jack Chen, Zhigang Miao, Ning Xin, Luoxiu Huang, Emily G. Allen, Hao Wu, Xingshun Xu, Peng Jin   +15 more
doaj   +1 more source

Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics

Beilstein Journal of Organic Chemistry, 2014
In this work we present for the first time the synthesis of novel 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) derivatives that can be used as tools in the emerging field of epigenetics for deciphering chemical biology of TET-mediated ...
Anna Chentsova, Era Kapourani, Athanassios Giannis   +2 more
doaj   +1 more source

Direct Conjugation of Peptides and 5‑Hydroxymethylcytosine in DNA

, 2015
Recent discovery of functional 5-hydroxymethylcytosine in vertebrate genomes prompted for elaboration of methods to localize this modification at the nucleotide resolution level.
Saulius Serva (1583020), Aru̅nas Lagunavičius (1583017)   +1 more
core   +1 more source

Loss of 5-hydroxymethylcytosine in cancer: Cause or consequence?

Genomics, 2014
Discovery of the enzymatic activity that catalyses oxidation of 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC) mediated by the MLL (KMT2A) fusion partner TET1 has sparked intense research to understand the role this new DNA modification has in cancer.
Ficz, Gabriella, Gribben, John G.
openaire   +2 more sources

Epigenetic Regulations in Neural Stem Cells and Neurological Diseases

Stem Cells International, 2018
Among the regulatory mechanisms of the renewal and differentiation of neural stem cells, recent evidences support that epigenetic modifications such as DNA methylation, histone modification, and noncoding RNAs play critical roles in the regulation on the
Hang Zhou, Bin Wang, Hao Sun, Xingshun Xu, Yongxiang Wang   +4 more
doaj   +1 more source

Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine [PDF]

, 2013
5-Hydroxymethylcytosine (5-hmC) was recently identified as a relatively frequent base in eukaryotic genomes. Its physiological function is still unclear, but it is supposed to serve as an intermediate in DNA de novo demethylation. Using X-ray diffraction,
Renciuk, Daniel, Blacque, Olivier, Vorlickova, Michaela, Spingler, Bernhard; https://orcid.org/   +3 more
core   +1 more source

Ten-eleven Translocation-2 Regulates DNA Hydroxymethylation Status and Psoriasiform Dermatitis Progression in Mice

Acta Dermato-Venereologica, 2018
Epigenetics plays an important role in the development and progression of many diseases. There is increasing evidence for the importance of epigenetic modifications in the progression of psoriasis.
Xin Wang, Xinxin Liu, Xiaoru Duan, Ke Zhu, Song Zhang, Lu Gan, Nian Liu, Himanshu Jaypaul, Johanna T. Makamure, Zhangyin Ming, Hongxiang Chen   +10 more
doaj   +1 more source