Results 111 to 120 of about 8,428,479 (200)

Distribution of 5-hydroxymethylcytosine (5 hmC) and 5-methylcytosine (5 mC) in Ad-MSCs.

, 2014
Basal mRNA levels of (A) TET2 and (B) TET3 were determined by qRT-PCR in Ad-MSCs from young and old donors (each group: N = 6, n = 3). (C) Expression changes of TET2 and TET3 were confirmed on the protein level by Western blot analysis (N = 3/group). For
Anastasia Bachmann (531784), Ulrich Stöckle (359636), Andreas K. Nussler (359638), Sabrina Ehnert (359631), Xueying Yan (531782), Mihaela Culmes (531783), Zhiyong Wang (313131), Claudine Seeliger (531785), Lilianna Schyschka (531786), Paul A. De Sousa (531788), Afshin Rahmanian-Schwarz (531787), Jaroslav Pelisek (140993)   +11 more
core   +1 more source

Cell-Free DNA 5-Hydroxymethylcytosine Signatures for Lung Cancer Prognosis

Cells
Accurate prognostic markers are essential for guiding effective lung cancer treatment strategies. The level of 5-hydroxymethylcytosine (5hmC) in tissue is independently associated with overall survival (OS) in lung cancer patients.
Jianming Shao, Randall J. Olsen, Saro Kasparian, Chuan He, Eric H. Bernicker, Zejuan Li   +5 more
doaj   +1 more source

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis

, 2016
International audienceThe family of Ten-Eleven Translocation (TET) proteins is implicated in the process of active DNA demethy-lation and thus in epigenetic regulation.
Secardin, Lise, Plo, Isabelle, Saparbaev, Murat,, Ishchenko, Alexander A., Rameau, Philippe, Vainchenker, William, Saparbaev, Murat, A, Talhaoui, Ibtissam, A, Talhaoui, Ibtissam,, Abbes, Salem,, Abbes, Salem, A, Bernard, Olivier A., Cabagnols, Xenia, Mahfoudhi, Emna, Della Valle, Véronique   +14 more
core   +1 more source

HM-DyadCap - capture and mapping of 5-hydroxymethylcytosine/5-methylcytosine CpG dyads in mammalian DNA. [PDF]

Nucleic Acids Res
Engelhard L, Schiller D, Zambrano-Mila MS, Keliuotyte K, Buchmuller B, Tiwari S, Imig J, Simeone A, Schröter C, Becker S, Summerer D.   +10 more
europepmc   +2 more sources

Sequencing 5-hydroxymethylcytosine [PDF]

Nature Methods, 2012
openaire   +1 more source

Functional analysis of 5-hydroxymethylcytosine

, 2014
Mammalian DNA methylathion is a chemical reaction catalyzed by DNA methyltransferases (DNMTs) and involves the addition of a methyl group from the methyl donor SAM to the carbon 5 position of cytosine (C) in a CpG dinucleotide.
Ottaviano, Raffaele
core  

Crystal structures of B-DNA dodecamer containing the epigenetic modifications 5-hydroxymethylcytosine or 5-methylcytosine

, 2017
5-Hydroxymethylcytosine (5-hmC) was recently identified as a relatively frequent base in eukaryotic genomes. Its physiological function is still unclear, but it is supposed to serve as an intermediate in DNA de novo demethylation. Using X-ray diffraction,
Spingler, Bernhard, Renciuk, Daniel, Blacque, Olivier, Vorlickova, Michaela   +3 more
core  

The Involvement of 5-Hydroxymethylcytosine in Two DNA Metabolism Pathways: Transcription and double stranded DNA Breaks

, 2015
5-hydroxymethylcytosine (5hmC) is involved in various cellular processes, including transcriptional regulation, demethylation of 5-methylcytosine (5meC) and stem cell pluripotency.
Robertson, Julia
core  

Editorial: Beyond CpG Methylation: New Modifications in Eukaryotic DNA

Frontiers in Cell and Developmental Biology, 2018
Reinhard Stöger, Alexey Ruzov
doaj   +1 more source

5-hydroxymethylcytosine signatures of tissue as potential predictive markers for platinum resistance in epithelial ovarian cancer patients. [PDF]

Sci Rep
Xue Y, Yi Z, Yu P, Huang C, Li H, Zheng M, Yang Z, Xu S, Guo H, Chen L, Lin J, Zhao L.   +11 more
europepmc   +1 more source