Results 111 to 120 of about 16,942 (208)
Epigenetic Regulations in Neural Stem Cells and Neurological Diseases
Stem Cells International, 2018 Among the regulatory mechanisms of the renewal and differentiation of neural stem cells, recent evidences support that epigenetic modifications such as DNA methylation, histone modification, and noncoding RNAs play critical roles in the regulation on the
Hang Zhou +4 more
doaj +1 more source
The effect of morphine upon DNA methylation in ten regions of the rat brain [PDF]
, 2017 Morphine is one of the most effective analgesics in medicine. However, its use is associated with the development of tolerance and dependence. Recent studies demonstrating epigenetic changes in the brain after exposure to opiates have provided insight ...
Baccarelli, A +7 more
core +1 more source
5-Hydroxymethylcytosine: A stable or transient DNA modification?
Genomics, 2014 The DNA base 5-hydroxymethylcytosine (5hmC) is produced by enzymatic oxidation of 5-methylcytosine (5mC) by 5mC oxidases (the Tet proteins). Since 5hmC is recognized poorly by DNA methyltransferases, DNA methylation may be lost at 5hmC sites during DNA replication.
Hahn, Maria A. +2 more
openaire +2 more sources
Acta Dermato-Venereologica, 2018 Epigenetics plays an important role in the development and progression of many diseases. There is increasing evidence for the importance of epigenetic modifications in the progression of psoriasis.
Xin Wang +10 more
doaj +1 more source
PLoS ONE, 2013 Covalent modification of cytosine nucleotides within the genome encode essential epigenetic information, with methylation (5meC) and hydroxymethylation (5hmC) having received most attention.
Yan Li, Chris O'Neill
doaj +1 more source
Comprehensive mapping of 5-hydroxymethylcytosine epigenetic dynamics in axon regeneration
Epigenetics, 2017 In contrast to central nervous system neurons, dorsal root ganglia (DRG) neurons can switch to a regenerative state after peripheral axotomy. In a screen for chromatin regulators of the regenerative responses in this conditioning lesion paradigm, we ...
Yong-Hwee Eddie Loh +5 more
doaj +1 more source
Functional Implications of DNA Methylation in Adipose Biology. [PDF]
, 2019 The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
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Cell-Free DNA 5-Hydroxymethylcytosine Signatures for Lung Cancer Prognosis. [PDF]
CellsAccurate prognostic markers are essential for guiding effective lung cancer treatment strategies. The level of 5-hydroxymethylcytosine (5hmC) in tissue is independently associated with overall survival (OS) in lung cancer patients.
Shao J +5 more
europepmc +2 more sources
Early-life stress links 5-hydroxymethylcytosine to anxiety-related behaviors
Epigenetics, 2017 Environmental stress contributes to the development of psychiatric disorders, including posttraumatic stress disorder and anxiety. While even acute stress alters gene expression, the molecular mechanisms underlying these changes remain largely unknown. 5-
Ligia A. Papale +3 more
doaj +1 more source
Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques [PDF]
, 2017 The epigenetic modification of 5-hydroxymethylcytosine (5hmC) is receiving great attention due to its potential role in DNA methylation reprogramming and as a cell state identifier.
Dunican, Donncha S. +6 more
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