Results 101 to 110 of about 8,428,479 (200)

5-Hydroxymethylcytosine Expression in Metastatic Melanoma versus Nodal Nevus in Sentine Lymph Node Biopsies

, 2015
Sentinel lymph node biopsies are conducted to stage patients with newly-diagnosed melanomas that have histopathologic attributes conferring defined levels of metastatic potential. Because benign nevic cells may also form ‘deposits ’ in lymph nodes (nodal
George F. Murphy, Christine G. Lian, Jonathan J. Lee, Granter, Scott, Zhan, Qian, Shuyun Xu, Scott R. Granter, Xu, Shuyun, Lee, Jonathan J., Lian, Christine, Qian Zhan, Guo, Weimin, Laga, Alvaro, Alvaro C. Laga, Weimin Guo, Saavedra, Arturo, Arturo Saavedra, Murphy, George   +17 more
core   +1 more source

5'-Methylcytosine and 5'-hydroxymethylcytosine each provide epigenetic information to the mouse zygote.

PLoS ONE, 2013
Covalent modification of cytosine nucleotides within the genome encode essential epigenetic information, with methylation (5meC) and hydroxymethylation (5hmC) having received most attention.
Yan Li, Chris O'Neill
doaj   +1 more source

Electrochemical signal-amplified detection of 5-methylcytosine and 5-hydroxymethylcytosine in DNA using glucose modification coupled with restriction endonucleases

, 2018
A sensitive electrochemical assay based on glucose modification coupled with restriction endonucleases was fabricated for the detection of 5-methylcytosine and 5-hydroxymethylcytosine in DNA.
Hongfei Chen, Chenxin Cai, Jiu-Ju Feng, Yin Yang, Guoqing Yang, Hui Zhang   +5 more
core   +1 more source

Accurate prediction of RNA 5-hydroxymethylcytosine modification by utilizing novel position-specific gapped k-mer descriptors

, 2020
RNA modification is an essential step towards generation of new RNA structures. Such modification is potentially able to modify RNA function or its stability.
Mahtab Uddin, Ghazaleh Taherzadeh, Taherzadeh, G, Sajid Ahmed, Zahid Hossain, Ahmed, S, Sharma, A, Dehzangi, A, Uddin, M, Shatabda, S, Hossain, Z, Abdollah Dehzangi, Swakkhar Shatabda, Alok Sharma   +13 more
core   +1 more source

Comprehensive mapping of 5-hydroxymethylcytosine epigenetic dynamics in axon regeneration

Epigenetics, 2017
In contrast to central nervous system neurons, dorsal root ganglia (DRG) neurons can switch to a regenerative state after peripheral axotomy. In a screen for chromatin regulators of the regenerative responses in this conditioning lesion paradigm, we ...
Yong-Hwee Eddie Loh, Andrew Koemeter-Cox, Mattéa J. Finelli, Li Shen, Roland H. Friedel, Hongyan Zou   +5 more
doaj   +1 more source

Early-life stress links 5-hydroxymethylcytosine to anxiety-related behaviors

Epigenetics, 2017
Environmental stress contributes to the development of psychiatric disorders, including posttraumatic stress disorder and anxiety. While even acute stress alters gene expression, the molecular mechanisms underlying these changes remain largely unknown. 5-
Ligia A. Papale, Andy Madrid, Sisi Li, Reid S. Alisch   +3 more
doaj   +1 more source

Epigenetic shielding: 5-hydroxymethylcytosine and 5-carboxylcytosine modulate UV induction of DNA photoproducts [PDF]

, 2014
Maintaining the balance between dynamic DNA methylation and demethylation is crucial to mammalian development and pathogenesis. In vitro methylation at the C-5 position of cytosine enhances cyclobutane pyrimidine dimer (CPD) formation and promotes ...
Liu, Jue
core  

Syntheses of 5-Formyl- and 5-Carboxyl-dC Containing DNA Oligos as Potential Oxidation Products of 5-Hydroxymethylcytosine in DNA

, 2016
To investigate the potential oxidation products of 5-hydroxymethylcytosine (5-hmC)-containing DNA, we present here efficient syntheses of 5-formyl- and 5-methoxycarbonyl-2′-deoxycytidine phosphoramidites.
Chuan He (178952), Qing Dai (552194)
core   +1 more source

DNA-friendly Cu(ii)/TEMPO-catalyzed 5-hydroxymethylcytosine-specific oxidation

, 2017
An allyl alcohol-selective oxidant Cu(ii)/TEMPO complex makes it possible to specifically detect 5-hydroxymethylcytosine in the human brain genome using a DNA sequence analyzer after a very easy pretreatment.
Taku Matsushita, Genta Nagae, Akimitsu Okamoto, Hiroyuki Aburatani, Yuya Moriyama   +4 more
core   +1 more source

Electrochemical sensor for the analysis of 5-hydroxymethylcytosine in the presence of cytosine using pencil graphite electrode

<p>In recent years, important efforts have been made to elucidate the mechanisms of epigenetic regulation, and one of the most studied epigenetic modifications was DNA methylation/demethylation.
Gurbuz, Manolya Mujgan, Ozkan, Sibel A., Topal, Burcu Dogan, Bilge, Selva   +3 more
core   +1 more source