Results 101 to 110 of about 16,942 (208)

Short- and long-term effects of 56Fe irradiation on cognition and hippocampal DNA methylation and gene expression. [PDF]

, 2016
BackgroundAstronauts are exposed to 56Fe ions that may pose a significant health hazard during and following prolonged missions in deep space. We showed previously that object recognition requiring the hippocampus, a structure critical for cognitive ...
Fareh, Fatema, Impey, Soren, Jopson, Timothy, Marzulla, Tessa, Pelz, Carl, Raber, Jacob, Riparip, Lara-Kirstie, Rosi, Susanna, Stewart, Blair, Tafessu, Amanuel, Turker, Mitchell S, Zuloaga, Damian   +11 more
core  

Cytosine 5-Hydroxymethylation of the LZTS1 Gene Is Reduced in Breast Cancer [PDF]

, 2013
Change of DNA cytosine methylation (5mC) is an early event in the development of cancer, and the recent discovery of a 5-hydroxymethylated form (5hmC) of cytosine suggests a regulatory epigenetic role that might be different from 5-methylcytosine.
Matthias, Wielscher, Liou, Willy, Pulverer, Walter, Singer, Christian F., Rappaport-Fuerhauser, Christine, Kandioler, Daniela, Egger, Gerda, Weinhäusel, Andreas   +7 more
core   +1 more source

Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs

Clinical Epigenetics, 2019
Background Accumulating evidence suggests that epigenetic changes play key roles in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the dynamic regulation of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in diabetic peripheral ...
Er-Feng Yuan, Ying Yang, Lin Cheng, Xujing Deng, Shao-Min Chen, Xin Zhou, Song-Mei Liu   +6 more
doaj   +1 more source

Detection of modified forms of cytosine using sensitive immunohistochemistry [PDF]

, 2016
Methylation of cytosine bases (5-methylcytosine, 5mC) occurring in vertebrate genomes is usually associated with transcriptional silencing. 5-hydroxylmethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) are the recently discovered
Abakir, Abdulkadir, Johnson, Andrew D., Laurent, Patrick, Ruzov, Alexey, Wheldon, Lee M.   +4 more
core   +1 more source

Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics

Beilstein Journal of Organic Chemistry, 2014
In this work we present for the first time the synthesis of novel 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) derivatives that can be used as tools in the emerging field of epigenetics for deciphering chemical biology of TET-mediated ...
Anna Chentsova, Era Kapourani, Athanassios Giannis   +2 more
doaj   +1 more source

Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice

Cell Reports, 2018
Summary: 5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC and its writers, ten-eleven translocation (Tet) proteins, in stress-induced response have yet to be ...
Ying Cheng, Miao Sun, Li Chen, Yujing Li, Li Lin, Bing Yao, Ziyi Li, Zhiqin Wang, Jack Chen, Zhigang Miao, Ning Xin, Luoxiu Huang, Emily G. Allen, Hao Wu, Xingshun Xu, Peng Jin   +15 more
doaj   +1 more source

5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary [PDF]

, 2012
5-Methylcytosine (5-mC) is an epigenetic modification associated with gene repression. Recent studies demonstrated that 5-mC can be enzymatically oxidised into 5-hydroxymethylcytosine and further into 5-formylcytosine (5-fC) and 5-carboxylcytsine (5-caC).
Abakir, Abdulkadir, Alioui, Anthony, Ferjentsik, Zoltan, Johnson, Andrew D., Ruzov, Alexey, Wheldon, Lee M.   +5 more
core   +2 more sources

Profiling of oxBS-450K 5-hydroxymethylcytosine in human placenta and brain reveals enrichment at imprinted loci

Epigenetics, 2018
DNA methylation (5-methylcytosine, 5 mC) is involved in many cellular processes and is an epigenetic mechanism primarily associated with transcriptional repression.
Jose Ramon Hernandez Mora, Marta Sanchez-Delgado, Paolo Petazzi, Sebastian Moran, Manel Esteller, Isabel Iglesias-Platas, David Monk   +6 more
doaj   +1 more source

Diesel exhaust and house dust mite allergen lead to common changes in the airway methylome and hydroxymethylome. [PDF]

, 2018
Exposures to diesel exhaust particles (DEP) from traffic and house dust mite (HDM) allergens significantly increase risks of airway diseases, including asthma. This negative impact of DEP and HDM may in part be mediated by epigenetic mechanisms.
Baccarelli, Andrea, Brandt, Eric B, Burleson, JD, Chen, Xiaoting, Ji, Hong, Weirauch, Matthew T, Zhang, Xiang, Zhang, Xue   +7 more
core  

Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus [PDF]

, 2016
Measures, completers, and wave of investigations. Figure S1. Controlling for IQ in the final model. Latent factors EF, ToM, ASD, and ADHD were regressed on IQ in the full final model (Figure A), nonsignificant paths were represented by dotted lines ...
Andrew Pickles (107698), Catherine Jones (355778), Emily Simonoff (4584358), Francesca Happé (185997), Gillian Baird (703489), Steve Lukito (4584361), Tony Charman (322938)   +6 more
core   +5 more sources