Results 21 to 30 of about 29,834 (207)
Total DNA methylation as a biomarker of DNA damage and tumor malignancy in intracranial meningiomas
BMC Cancer, 2020 Background Meningiomas are the most common primary intracranial tumors in adults. They are initially detected with neuroimaging techniques, but definite histological diagnosis requires tumor surgery to collect tumor tissue.
Anna-Maria Barciszewska
doaj +1 more source
5-Methylcytosine and 5-Hydroxymethylcytosine Signatures Underlying Pediatric Cancers
Epigenomes, 2019 In addition to the genetic variations, recent evidence has shown that DNA methylation of both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) underlies the pathogenesis of pediatric cancer. Given the high mortality rate, there is an urgent need
Shalu Jhanwar, Ajinkya Deogade
doaj +1 more source
PLoS ONE, 2021 Single-molecule Real-Time (SMRT) sequencing can easily identify sites of N6-methyladenine and N4-methylcytosine within DNA sequences, but similar identification of 5-methylcytosine sites is not as straightforward.
Brian P Anton +3 more
doaj +1 more source
Cells, 2023 Keratinocytes are one of the primary cells affected by psoriasis inflammation. Our study aimed to delve deeper into their morphology, transcriptome, and epigenome changes in response to psoriasis-like inflammation.
Ameneh Ghaffarinia +11 more
doaj +1 more source
Oxidative damage to 5-methylcytosine in DNA [PDF]
Nucleic Acids Research, 1995 Exposure of pyrimidines of DNA to ionizing radiation under aerobic conditions or oxidizing agents results in attack on the 5,6 double bond of the pyrimidine ring or on the exocyclic 5-methyl group. The primary product of oxidation of the 5,6 double bond of thymine is thymine glycol, while oxidation of the 5-methyl group yields 5-hydroxymethyluracil ...
S, Zuo, R J, Boorstein, G W, Teebor
openaire +2 more sources
UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures
Epigenetics, 2017 The 5-methylcytosine (5mC) modification regulates multiple cellular processes and is faithfully maintained following DNA replication. In addition to DNA methyltransferase (DNMT) family proteins, ubiquitin-like PHD and ring finger domain-containing ...
Yidan Liu +6 more
doaj +1 more source
The Metabolism of 5-methylcytosine Residues in DNA
Physiological Research, 2018 The fundamental biochemical processes of 5-methylcytosine (5-mC) synthesis, maintenance, conversion and removal determine the time and spatial pattern of DNA methylation. This has a strong effect on a plethora of physiological aspects of cellular metabolism.
R, Murín +4 more
openaire +2 more sources
Advanced Science, 2023 Methylating RNA post‐transcriptionally is emerging as a significant mechanism of gene regulation in eukaryotes. The crosstalk between RNA methylation and histone modification is critical for chromatin state and gene expression in mammals.
Daolei Zhang +9 more
doaj +1 more source
Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease
npj Parkinson's Disease, 2017 5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains.
Reinhard Stöger +3 more
doaj +1 more source
5-methylcytosine turnover: Mechanisms and therapeutic implications in cancer
Frontiers in Molecular Biosciences, 2022 DNA methylation at the fifth position of cytosine (5mC) is one of the most studied epigenetic mechanisms essential for the control of gene expression and for many other biological processes including genomic imprinting, X chromosome inactivation and ...
Marion Turpin +3 more
doaj +1 more source