5-Methylcytosine methylation predicts cervical cancer prognosis, shaping immune cell infiltration [PDF]
Journal of International Medical ResearchBackground Epigenetics, encompassing DNA and RNA modifications, has emerged as a prominent area of research in the post-genomic era. Numerous studies have elucidated the impact of epigenetics on tumor regulation.
Luyang Su +8 more
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DNA of Drosophila melanogaster contains 5-methylcytosine [PDF]
EMBO Journal, 2000 It is commonly accepted that the DNA of Drosophila melanogaster does not contain 5-methylcytosine, which is essential in the development of most eukaryotes. We have developed a new, highly specific and sensitive assay to detect the presence of 5-methylcytosine in genomic DNA.
Humaira Gowher, Albert Jeltsch
exaly +3 more sources
Double and single stranded detection of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore sequencing. [PDF]
Commun Biol5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are modified versions of cytosine in DNA with roles in regulating gene expression. Using whole genomic DNA from mouse cerebellum, we benchmark 5mC and 5hmC detection by Oxford Nanopore ...
Halliwell DO +4 more
europepmc +2 more sources
RNA 5-Methylcytosine Modification: Regulatory Molecules, Biological Functions, and Human Diseases. [PDF]
Genomics Proteomics BioinformaticsRNA methylation modifications influence gene expression, and disruptions of these processes are often associated with various human diseases. The common RNA methylation modification 5-methylcytosine (m5C), which is dynamically regulated by writers ...
Lu Y +7 more
europepmc +2 more sources
Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing [PDF]
eLife5-Methylcytosine (m5C) is one of the posttranscriptional modifications in mRNA and is involved in the pathogenesis of various diseases. However, the capacity of existing assays for accurately and comprehensively transcriptome-wide m5C mapping still needs
Jiale Zhou +13 more
doaj +2 more sources
5-methylcytosine regulated CCNL2 promotes tumorigenesis and cisplatin resistance of ovarian cancer with therapeutic implications [PDF]
Journal of Ovarian ResearchBackgroud Ovarian cancer (OC) is the most lethal gynecological tumor, primarily due to resistance to chemotherapy. Cyclin L2 (CCNL2) is a novel member of the cyclin family and mainly localized in nucleus.
Kai Zhang +5 more
doaj +2 more sources
The Methylation Game: Epigenetic and Epitranscriptomic Dynamics of 5-Methylcytosine
Frontiers in Cell and Developmental Biology, 2022 DNA and RNA methylation dynamics have been linked to a variety of cellular processes such as development, differentiation, and the maintenance of genome integrity.
Adele Alagia, Monika Gullerova
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Epigenetics of Modified DNA Bases: 5-Methylcytosine and Beyond
Frontiers in Genetics, 2018 Modification of DNA bases plays vital roles in the epigenetic control of gene expression in both animals and plants. Though much attention is given to the conventional epigenetic signature 5-methylcytosine (5-mC), the field of epigenetics is attracting ...
Suresh Kumar +2 more
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Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease [PDF]
Advanced ScienceAlzheimer's disease (AD) is associated with genetic risk factors and widespread epigenetic alterations. 5‐Hydroxymethylcytosine (5hmC), an oxidized derivative of 5‐methylcytosine (5mC), constitutes up to 20% of 5mC in neuronal DNA and is implicated in ...
Zi‐Xin Wang +15 more
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Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis.
, 2023 The epigenetic modification 5-methylcytosine plays a vital role in development, cell specific gene expression and disease states. The selective chemical modification of the 5-methylcytosine methyl group is challenging. Currently, no such chemistry exists.
core +5 more sources