Results 31 to 40 of about 20,996,854 (289)

Role of 5-methylcytosine in determining the prognosis, tumor microenvironment, and applicability of precision medicine in patients with hepatocellular carcinoma

Frontiers in Genetics, 2022
Background: 5-methylcytosine has a profound impact on the development and progression of hepatocellular carcinoma. The aim of this study was to investigate the usefulness of 5-methylcytosine in determining the prognosis, tumor microenvironment, and ...
Mingyuan Luan, Min Zhao, Haiying Wang, Rongjian Xu, Jinzhen Cai   +4 more
doaj   +1 more source

Identification and validation of 5-methylcytosine-associated genes in diffuse large B-cell lymphoma

Heliyon, 2023
5-methylcytosine modifications play a significant role in carcinogenesis; however, studies exploring 5-methylcytosine-related genes in diffuse large B-cell lymphoma patients are lacking.
Cheng Xing, Shicong Zhu, Wenzhe Yan, Hongkai zhu, Zineng Huang, Yan Zhao, Wancheng Guo, Huifang Zhang, Le Yin, Xueqin Ruan, Zeyue Deng, Peilong Wang, Zhao Cheng, Zhihua Wang, Hongling Peng   +14 more
doaj   +1 more source

DNA 5-methylcytosine detection and methylation phasing using PacBio circular consensus sequencing

bioRxiv, 2023
Long single-molecular sequencing, such as PacBio circular consensus sequencing (CCS) and nanopore sequencing, is advantageous in detecting DNA 5-methylcytosine (5mC) in CpGs, especially in repetitive genomic regions.
Peng Ni, Fan Nie, Zeyu Zhong, Jinrui Xu, Neng Huang, Jun Zhang, Haochen Zhao, You Zou, Yuanfeng Huang, Jinchen Li, Chuan-Le Xiao, Feng Luo, Jianxin Wang   +12 more
semanticscholar   +1 more source

Bifunctional Role of Fe(II)/2OG-Dependent TET Family 5-Methylcytosine Dioxygenases and ALKBH2,3 in Modified Cytosine Demethylation

BioChem, 2022
Three forms of methylated cytosines are present in the eukaryotic genome: 3-methylcytosine, 4-methylcytosine and 5-methylcytosine. 3-methylcytosines create methyl lesions, which impair local DNA function and flexibility, resulting in replication and ...
Aninda Sundar Dey
doaj   +1 more source

5-Methylcytosine Analysis of miRNAs in Minimal Change Disease. [PDF]

Biotechnol Appl Biochem
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Zeng H, Li D, Li Y, Yun C, Zhang X, Gong W, Xiao M, Li H, Zeng Z, Tan R, Yang Y, Luan S, Dai Y, Yin L, Tang D.   +14 more
europepmc   +2 more sources

5-methylcytosine RNA methyltransferases and their potential roles in cancer

Journal of Translational Medicine, 2022
In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key player in regulating RNA metabolism and function through coding as well as non-coding RNAs.
Mingyang Li, Zijia Tao, Yiqiao Zhao, Lei Li, Jia-Bin Zheng, Zeyu Li, Xiaonan Chen   +6 more
semanticscholar   +1 more source

Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine

Signal Transduction and Targeted Therapy, 2022
Cancer is one of the major diseases threatening human life and health worldwide. Epigenetic modification refers to heritable changes in the genetic material without any changes in the nucleic acid sequence and results in heritable phenotypic changes ...
Chen Xue, Qingfei Chu, Q. Zheng, Shiman Jiang, Zhengyi Bao, Yuanshuai Su, Juan-fen Lu, Lan-Ju Li   +7 more
semanticscholar   +1 more source

Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer

Molecular Cancer, 2023
Background RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors.
Vanessa Ortiz-Barahona, M. Soler, V. Davalos, C. García-Prieto, M. Janin, F. Setién, Irene Fernández-Rebollo, J. Bech-Serra, C. de la Torre, S. Guil, A. Villanueva, Pei Zhang, Li Yang, M. Guarnacci, Ulrike Schumann, T. Preiss, U. Balaseviciute, R. Montal, J. Llovet, M. Esteller   +19 more
semanticscholar   +1 more source

5-Hydroxymethylcytosine Loss in Conjunctival Melanoma

Dermatopathology, 2021
Aims: Conjunctival and cutaneous melanoma partially share similar clinical and molecular backgrounds. As 5-hydroxymethylcytosine (5-hmC) loss has been demonstrated in cutaneous melanoma, we decided to assess if similar changes were occurring in ...
Alexandre Stahl, Nicolo Riggi, Katya Nardou, Michael Nicolas, Gurkan Kaya, Alexandre Moulin   +5 more
doaj   +1 more source

Discovery of a Bacterial 5-Methylcytosine Deaminase [PDF]

Biochemistry, 2014
5-Methylcytosine is found in all domains of life, but the bacterial cytosine deaminase from Escherichia coli (CodA) will not accept 5-methylcytosine as a substrate. Since significant amounts of 5-methylcytosine are produced in both prokaryotes and eukaryotes, this compound must eventually be catabolized and the fragments recycled by enzymes that have ...
Hitchcock, Daniel S., Fedorov, Alexander A., Fedorov, Elena V., Almo, Steven C., Raushel, Frank M.   +4 more
openaire   +2 more sources