Results 51 to 60 of about 20,996,854 (289)

Genetic variants in m5C modification core genes are associated with the risk of Chinese pediatric acute lymphoblastic leukemia: A five-center case–control study

Frontiers in Oncology, 2023
ObjectiveTo explore the functions of the polymorphisms in 5-methylcytosine (m5C) modification-related coding genes on the susceptibility of pediatric acute lymphoblastic leukemia (ALL).MethodsCase–control study and multinomial logistic regression ...
Xueliang Wang, Decheng Deng, Yaping Yan, Mansi Cai, Xiaodan Liu, Ailing Luo, Shanshan Liu, Xiaohong Zhang, Hua Jiang, Xiaoping Liu   +9 more
doaj   +1 more source

Detection of 5-methylcytosine in DNA sequences [PDF]

Nucleic Acids Research, 1978
Col E1 DNA has methylated cytosine in the sequence 5'-CC*(A/T)GG-3' and methylated adenine in the sequence 5'-GA*TC-3' at the positions indicated by asterisks(*). When the Maxam-Gilbert DNA sequencing method is applied to this DNA, the methylated cytosine (5-methylcytosine) is found to be less reactive to hydrazine than are cytosine and thymine, so ...
H, Ohmori, J I, Tomizawa, A M, Maxam
openaire   +2 more sources

Predicting RNA 5-Methylcytosine Sites by Using Essential Sequence Features and Distributions

BioMed Research International, 2022
Methylation is one of the most common and considerable modifications in biological systems mediated by multiple enzymes. Recent studies have shown that methylation has been widely identified in different RNA molecules.
Lei Chen, Zhandong Li, Shiqi Zhang, Yuhang Zhang, Tao Huang, Yunpeng Cai   +5 more
semanticscholar   +1 more source

Construction of a 5-methylcytosine-Related Molecular Signature to Inform the Prognosis and Immunotherapy of Lung Squamous Cell Carcinoma

, 2022
Methylation of cytosine residues resulting in 5-methylcytosine (5-mC) is an important epigenetic modification associated with tumorigenesis. The present study explored the relationship between methylation, prognosis, and immunotherapy of patients ...
Jun Zeng (403080), Rong He (25641), Kai Yang (73590), Wancheng Li (13960261), Xiaoli Feng (2601067), Xiafei Zhou (758513)   +5 more
core   +1 more source

5-Methylcytosine and 5-Hydroxymethylcytosine Signatures Underlying Pediatric Cancers

Epigenomes, 2019
In addition to the genetic variations, recent evidence has shown that DNA methylation of both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) underlies the pathogenesis of pediatric cancer. Given the high mortality rate, there is an urgent need
Shalu Jhanwar, Ajinkya Deogade
doaj   +1 more source

5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader

Cell Research, 2017
5-methylcytosine (m5C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unknown.
Xin Yang, Ying Yang, Bao-Fa Sun, Yu-Sheng Chen, Jiawei Xu, Weiyi Lai, Ang Li, Xing Wang, Devi Prasad Bhattarai, Wen Xiao, Huiying Sun, Qin Zhu, Hai-Li Ma, Samir Adhikari, Min Sun, Ya-Juan Hao, Bing Zhang, Chunmin Huang, Niu Huang, Guibin Jiang, Yong‐Liang Zhao, Hailin Wang, Ying-Pu Sun, Yun-Gui Yang   +23 more
semanticscholar   +1 more source

Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution

Nature Communications, 2021
Although various methods have been developed for sequencing cytosine modifications, it is still challenging for specific and quantitative sequencing of individual modification at base-resolution.
Yibin Liu, Zhiyuan Hu, Jingfei Cheng, Paulina Siejka-Zielińska, Jinfeng Chen, M. Inoue, A. Ahmed, Chun-Xiao Song   +7 more
semanticscholar   +1 more source

Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain. [PDF]

, 2011
Recent discovery of 5-hydroxymethylcytosine (5hmC) in genomic DNA raises the question how this sixth base is recognized by cellular proteins. In contrast to the methyl-CpG binding domain (MBD) of MeCP2, we found that the SRA domain of Uhrf1, an essential
Frauer, C., M. Cristina Cardoso, Leonhardt, Heinrich, Frauer, Carina, Bultmann, Sebastian, Casa, V., Valentina Casa, Frauer Carina, Hoffmann, T., Cardoso, M. Cristina, Leonhardt Heinrich, Antes, I., Casa Valentina, Iris Antes, Leonhart, H., Heinrich Leonhardt, Cardoso M. Cristina, Hoffmann Thomas, Hoffmann, Thomas, Antes Iris, Thomas Hoffmann, M Cristina Cardoso, Bultmann Sebastian, Bultmann, S., Antes, Iris, Casa, Valentina, Carina Frauer, Sebastian Bultmann   +27 more
core   +1 more source

Genome-wide identification of 5-methylcytosine sites in bacterial genomes by high-throughput sequencing of MspJI restriction fragments.

PLoS ONE, 2021
Single-molecule Real-Time (SMRT) sequencing can easily identify sites of N6-methyladenine and N4-methylcytosine within DNA sequences, but similar identification of 5-methylcytosine sites is not as straightforward.
Brian P Anton, Alexey Fomenkov, Victoria Wu, Richard J Roberts   +3 more
doaj   +1 more source

Unraveling Transcriptome Profile, Epigenetic Dynamics, and Morphological Changes in Psoriasis-like Keratinocytes: “Insights into Similarity with Psoriatic Lesional Epidermis”

Cells, 2023
Keratinocytes are one of the primary cells affected by psoriasis inflammation. Our study aimed to delve deeper into their morphology, transcriptome, and epigenome changes in response to psoriasis-like inflammation.
Ameneh Ghaffarinia, Szilárd Póliska, Ferhan Ayaydin, Aniko Goblos, Shahram Parvaneh, Máté Manczinger, Fanni Balogh, Lilla Erdei, Zoltán Veréb, Kornélia Szabó, Zsuzsanna Bata-Csörgő, Lajos Kemény   +11 more
doaj   +1 more source