Results 41 to 50 of about 11,684,120 (271)

Intrinsic and Extrinsic Connections of Tet3 Dioxygenase with CXXC Zinc Finger Modules. [PDF]

, 2013
Tet proteins are emerging as major epigenetic modulators of cell fate and plasticity. However, little is known about how Tet proteins are targeted to selected genomic loci in distinct biological contexts.
Christine S. Schmidt, Deng, Wen, Christine S. Schmidt (107838), Liu, Nan, Spada, Fabio, Heinrich Leonhardt, Leonhardt, Heinrich, Mengxi Wang, Weihua Qin, Heinrich Leonhardt (18589), Christine S Schmidt, Nan Liu (1630), Wen Deng, Fabio Spada, Schmidt, Christine S., Mengxi Wang (231051), Qin, Weihua, Wang, Mengxi, Nan Liu, Wen Deng (123626), Fabio Spada (107869), Weihua Qin (231053)   +21 more
core   +2 more sources

Deamination of 5-Methylcytosine Residues in Mammalian Cells [PDF]

Acta Naturae, 2009
DNA demethylation in mammalia occurs after fertilization and during embryogenesis and accompanies cell aging and cancer transformation. With the help of the primer extension reaction, MALDI MS and DNA cleavage by thymine DNA glycosylase deamination of 5-methylcytosine residues has been shown to take place when the model methylated DNA duplexes are ...
Gromenko, E., Spirin, P., Kubareva, E., Romanova, E., Prassolov, V., Shpanchenko, O., Dontsova, O.   +6 more
openaire   +4 more sources

Table3_Prognostic Characteristics and Immune Effects of N6-Methyladenosine and 5-Methylcytosine-Related Regulatory Factors in Clear Cell Renal Cell Carcinoma.XLSX

, 2022
In recent years, methylation modification regulators have been found to have essential roles in various tumor mechanisms. However, the relationships between N6-methyladenosine (m6A) and 5-methylcytosine (m5C) regulators and clear cell renal cell ...
Zeyu Li (4371955), Lei Li (29537), Yiqiao Zhao (9550013), Mingyang Li (516280), Xiaonan Chen (3181938), Zijia Tao (9550016), Jianyi Zheng (5705534)   +6 more
core   +1 more source

5-Methylcytosine and 5-hydroxymethylcytosine spatiotemporal profiles in the mouse zygote.

PLoS ONE, 2012
BackgroundIn the mouse zygote, DNA methylation patterns are heavily modified, and differ between the maternal and paternal pronucleus. Demethylation of the paternal genome has been described as an active and replication-independent process, although the ...
Juliette Salvaing, Tiphaine Aguirre-Lavin, Claire Boulesteix, Gaëtan Lehmann, Pascale Debey, Nathalie Beaujean   +5 more
doaj   +1 more source

Characterization of 5-methylcytosine and 5-hydroxymethylcytosine in human placenta cell types across gestation

Epigenetics, 2019
The placenta is an important organ in pregnancy, however, very little is understood about placental development at a molecular level. This includes the role of epigenetic mechanisms and how they change throughout gestation.
Rebecca L. Wilson, Maxime François, Tanja Jankovic-Karasoulos, Dale McAninch, Dylan McCullough, Wayne R. Leifert, Claire T. Roberts, Tina Bianco-Miotto   +7 more
doaj   +1 more source

Oxygenase Catalyzed 5-Methylcytosine Hydroxylation

Chemistry & Biology, 2009
Recent reports identify the oxygenase catalyzed production of 5-hydroxymethylcytosine as a modification to mammalian DNA (Kriaucionis and Heintz, 2009; Tahiliani et al., 2009). This discovery has potential far-reaching implications for epigenetic regulation and will stimulate efforts to identify new nucleic acid modifications.
Loenarz, C, Schofield, C
openaire   +3 more sources

5‐Methylcytosine in genes with methylation‐dependent regulation [PDF]

FEBS Letters, 1993
An asymmetric distribution of deoxy‐5‐methylcytidylic acid‐inhibiting restriction sites (dcm‐sites) takes place in ten human genes regulated by 5‐methylcytosine. These genes are dcm‐site enriched upstream and dcm‐site poor downstream. Along them, there is a scattering of hypermethylatable introns and hypomethylatable exons with a common code: the 5mCpG
Volpe, Pietro, Iacovacci, Paolo, Butler, Richard H., Eremenko, Tamilla   +3 more
openaire   +2 more sources

Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus [PDF]

, 2013
© 2013 Al-Mahdawi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are ...
Pook, MA, Sahar Al-Mahdawi, Mouro Pinto, R, Chiranjeevi Sandi, Sandi Chiranjeevi, Al-Mahdawi, S, Mouro Pinto Ricardo, Al-Mahdawi Sahar, Ricardo Mouro Pinto, Pook Mark A., Mark A Pook, Sandi, C   +11 more
core   +1 more source

Image4_Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer.TIF

, 2021
Background: DNA methylation is an important epigenetic modification, among which 5-methylcytosine methylation (5mC) is generally associated with tumorigenesis.
Xiaoning Li (581082), Ming Jiang (11433), Taisheng Liu (11085717), Xiaoshan Hu (728098), Jian Wang (5901), Guihong Liu (9351563), Jinye Zhang (1467106), Liyi Guo (11678977), Peng Yu (48605), Zili Dai (11678980), Jian Zhang (1682)   +10 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source