Results 61 to 70 of about 20,996,854 (289)

Oxidative damage to 5-methylcytosine in DNA [PDF]

Nucleic Acids Research, 1995
Exposure of pyrimidines of DNA to ionizing radiation under aerobic conditions or oxidizing agents results in attack on the 5,6 double bond of the pyrimidine ring or on the exocyclic 5-methyl group. The primary product of oxidation of the 5,6 double bond of thymine is thymine glycol, while oxidation of the 5-methyl group yields 5-hydroxymethyluracil ...
S, Zuo, R J, Boorstein, G W, Teebor
openaire   +2 more sources

The Metabolism of 5-methylcytosine Residues in DNA

Physiological Research, 2018
The fundamental biochemical processes of 5-methylcytosine (5-mC) synthesis, maintenance, conversion and removal determine the time and spatial pattern of DNA methylation. This has a strong effect on a plethora of physiological aspects of cellular metabolism.
R, Murín, M, Abdalla, N, Murínová, J, Hatok, D, Dobrota   +4 more
openaire   +2 more sources

Deamination of 5-Methylcytosine Residues in Mammalian Cells [PDF]

Acta Naturae, 2009
DNA demethylation in mammalia occurs after fertilization and during embryogenesis and accompanies cell aging and cancer transformation. With the help of the primer extension reaction, MALDI MS and DNA cleavage by thymine DNA glycosylase deamination of 5-methylcytosine residues has been shown to take place when the model methylated DNA duplexes are ...
Gromenko, E., Spirin, P., Kubareva, E., Romanova, E., Prassolov, V., Shpanchenko, O., Dontsova, O.   +6 more
openaire   +4 more sources

Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI [PDF]

, 2017
Background: Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmetric between the paternal and the ...
Katrien Smits, Catharina De Schauwer, Heras Garcia, Sonia, Smits, Katrien, De Schauwer, Catharina, Ann Van Soom, Van Soom, Ann, Sonia Heras   +7 more
core   +1 more source

Table3_Prognostic Characteristics and Immune Effects of N6-Methyladenosine and 5-Methylcytosine-Related Regulatory Factors in Clear Cell Renal Cell Carcinoma.XLSX

, 2022
In recent years, methylation modification regulators have been found to have essential roles in various tumor mechanisms. However, the relationships between N6-methyladenosine (m6A) and 5-methylcytosine (m5C) regulators and clear cell renal cell ...
Zeyu Li (4371955), Lei Li (29537), Yiqiao Zhao (9550013), Mingyang Li (516280), Xiaonan Chen (3181938), Zijia Tao (9550016), Jianyi Zheng (5705534)   +6 more
core   +1 more source

RNA 5‐Methylcytosine Modification Regulates Vegetative Development Associated with H3K27 Trimethylation in Arabidopsis

Advanced Science, 2023
Methylating RNA post‐transcriptionally is emerging as a significant mechanism of gene regulation in eukaryotes. The crosstalk between RNA methylation and histone modification is critical for chromatin state and gene expression in mammals.
Daolei Zhang, Weijun Guo, Ting Wang, Yifan Wang, Liang Le, Fan Xu, Yue Wu, Hada Wuriyanghan, Zinmay Renee Sung, Li Pu   +9 more
doaj   +1 more source

Oxygenase Catalyzed 5-Methylcytosine Hydroxylation

Chemistry & Biology, 2009
Recent reports identify the oxygenase catalyzed production of 5-hydroxymethylcytosine as a modification to mammalian DNA (Kriaucionis and Heintz, 2009; Tahiliani et al., 2009). This discovery has potential far-reaching implications for epigenetic regulation and will stimulate efforts to identify new nucleic acid modifications.
Loenarz, C, Schofield, C
openaire   +3 more sources

5‐Methylcytosine in genes with methylation‐dependent regulation [PDF]

FEBS Letters, 1993
An asymmetric distribution of deoxy‐5‐methylcytidylic acid‐inhibiting restriction sites (dcm‐sites) takes place in ten human genes regulated by 5‐methylcytosine. These genes are dcm‐site enriched upstream and dcm‐site poor downstream. Along them, there is a scattering of hypermethylatable introns and hypomethylatable exons with a common code: the 5mCpG
Volpe, Pietro, Iacovacci, Paolo, Butler, Richard H., Eremenko, Tamilla   +3 more
openaire   +2 more sources

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

Cell, 2011
SUMMARY Cytosine methylation is the major covalent modification of mammalian genomic DNA and plays important roles in transcriptional regulation. The molecular mechanism underlying the enzymatic removal of this epigenetic mark, however, remains elusive ...
Junjie U. Guo, Yijing Su, C. Zhong, G. Ming, Hongjun Song   +4 more
semanticscholar   +1 more source

Intrinsic and Extrinsic Connections of Tet3 Dioxygenase with CXXC Zinc Finger Modules. [PDF]

, 2013
Tet proteins are emerging as major epigenetic modulators of cell fate and plasticity. However, little is known about how Tet proteins are targeted to selected genomic loci in distinct biological contexts.
Christine S. Schmidt, Deng, Wen, Christine S. Schmidt (107838), Liu, Nan, Spada, Fabio, Heinrich Leonhardt, Leonhardt, Heinrich, Mengxi Wang, Weihua Qin, Heinrich Leonhardt (18589), Christine S Schmidt, Nan Liu (1630), Wen Deng, Fabio Spada, Schmidt, Christine S., Mengxi Wang (231051), Qin, Weihua, Wang, Mengxi, Nan Liu, Wen Deng (123626), Fabio Spada (107869), Weihua Qin (231053)   +21 more
core   +1 more source