Results 71 to 80 of about 20,996,854 (289)
Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease
npj Parkinson's Disease, 2017 5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains.
Reinhard Stöger +3 more
doaj +1 more source
5-methylcytosine turnover: Mechanisms and therapeutic implications in cancer
Frontiers in Molecular Biosciences, 2022 DNA methylation at the fifth position of cytosine (5mC) is one of the most studied epigenetic mechanisms essential for the control of gene expression and for many other biological processes including genomic imprinting, X chromosome inactivation and ...
Marion Turpin +3 more
doaj +1 more source
Genes, 2019 5-methylcytosine (m5C) is an abundant RNA modification that’s presence is reported in a wide variety of RNA species, including cytoplasmic and mitochondrial ribosomal RNAs (rRNAs) and transfer RNAs (tRNAs), as well as messenger RNAs (mRNAs), enhancer ...
K. Bohnsack, C. Höbartner, M. Bohnsack
semanticscholar +1 more source
Science Advances, 2021 DNA mismatch repair is essential for protecting the human genome from damage induced by 5-methylcytosine deamination.
H. Fang +5 more
semanticscholar +1 more source
, 2021 Background: DNA methylation is an important epigenetic modification, among which 5-methylcytosine methylation (5mC) is generally associated with tumorigenesis.
Xiaoning Li (581082) +10 more
core +1 more source
Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA
Nature Communications, 2022 Eukaryotic DNA can be methylated as 5-methylcytosine and N6-methyladenine, but whether other forms of DNA methylation occur has been controversial. Here the authors show that a bacterial DNA methyltransferase was acquired >60 Mya in bdelloid rotifers ...
Fernando Rodriguez +3 more
doaj +1 more source
ACS Omega, 2020 Methylation of cytosine has been known to play a significant role in epigenetic regulation. 5-Methylcytosine was among the first base modification that was discovered for the capability to facilitate B/Z-DNA transition as observed in CG repeated tracks ...
Vorasit Vongsutilers +2 more
doaj +2 more sources
Distribution of 5-methylcytosine in chromatin. [PDF]
Proceedings of the National Academy of Sciences, 1977 The content of 5-methylcytosine in eukaryotic DNA was measured by mass spectrometry. Almost equal amounts of methylated cytosine were found in the DNA of various tissues of the chicken. When chromatin or nuclei were digested with micrococcal nuclease, 50% of the DNA was found to be nuclease resistant.
A, Razin, H, Cedar
openaire +2 more sources
Multiple links between 5-methylcytosine content of mRNA and translation
BMC Biology, 2020 5-Methylcytosine (m5C) is a prevalent base modification in tRNA and rRNA but it also occurs more broadly in the transcriptome, including in mRNA, where it serves incompletely understood molecular functions.
Ulrike Schumann +8 more
semanticscholar +1 more source
5-Methylcytosine and 5-hydroxymethylcytosine spatiotemporal profiles in the mouse zygote.
PLoS ONE, 2012 BackgroundIn the mouse zygote, DNA methylation patterns are heavily modified, and differ between the maternal and paternal pronucleus. Demethylation of the paternal genome has been described as an active and replication-independent process, although the ...
Juliette Salvaing +5 more
doaj +1 more source