Results 81 to 90 of about 20,996,854 (289)

Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance 5-Methylcytosine (m5C) is one of the most abundant RNA modifications, but its function in adult stem cell development remains poorly defined.
F. Zou, Renjun Tu, Bo Duan, Zhenlin Yang, Zhaohua Ping, Xiaoqing Song, Shiyuan Chen, Andrew Price, Hua Li, Allison R. Scott, Anoja Perera, Sisi Li, T. Xie   +12 more
semanticscholar   +1 more source

RNA 5-methylcytosine regulates YBX2-dependent liquid-liquid phase separation

Fundamental Research, 2021
5-Methylcytosine (m5C) is one of the most prevalent internal modifications of messenger RNA (mRNA) in higher eukaryotes. Here we report that Y box protein 2 (YBX2) serves as a novel mammalian m5C binding protein to undergo liquid-liquid phase separation (
Xiuzhi Wang, Mengke Wang, Xinyuan Dai, Xiao Han, Yu Zhou, Weiyi Lai, Liyuan Zhang, Ying Yang, Yusheng Chen, Hailin Wang, Yong‐Liang Zhao, Bin Shen, Yuhan Zhang, Ying Huang, Yun-Gui Yang   +14 more
semanticscholar   +1 more source

Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus [PDF]

, 2013
© 2013 Al-Mahdawi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are ...
Pook, MA, Sahar Al-Mahdawi, Mouro Pinto, R, Chiranjeevi Sandi, Sandi Chiranjeevi, Al-Mahdawi, S, Mouro Pinto Ricardo, Al-Mahdawi Sahar, Ricardo Mouro Pinto, Pook Mark A., Mark A Pook, Sandi, C   +11 more
core   +1 more source

RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay.

Molecules and Cells, 2019
The maternal-to-zygotic transition (MZT) is a conserved and fundamental process during which the maternal environment is converted to an environment of embryonic-driven development through dramatic reprogramming.
Ying Yang, Lu Wang, Xiao Han, Wenlan Yang, Mengmeng Zhang, Hai-Li Ma, Bao-Fa Sun, Ang Li, Jun Xia, J. Chen, Jian-Chien Heng, Baixing Wu, Yu-Sheng Chen, Jiawei Xu, Xin Yang, Huan Yao, Jiawei Sun, Cong Lyu, Hailin Wang, Ying Huang, Ying-pu Sun, Yong‐Liang Zhao, A. Meng, Jinbiao Ma, Feng Liu, Yun-Gui Yang   +25 more
semanticscholar   +1 more source

Characterization of 5-methylcytosine and 5-hydroxymethylcytosine in human placenta cell types across gestation

Epigenetics, 2019
The placenta is an important organ in pregnancy, however, very little is understood about placental development at a molecular level. This includes the role of epigenetic mechanisms and how they change throughout gestation.
Rebecca L. Wilson, Maxime François, Tanja Jankovic-Karasoulos, Dale McAninch, Dylan McCullough, Wayne R. Leifert, Claire T. Roberts, Tina Bianco-Miotto   +7 more
doaj   +1 more source

Sequence-selective 5-methylcytosine oxidation for epigenotyping [PDF]

Nucleic Acids Symposium Series, 2005
Methylation of DNA is an epigenetic modification that can play an important role in the control of gene expression in mammalian cells. The development of a simple and convenient method for site-specific discrimination of cytosine methylation is imperative for genomic studies.
Akimitsu, Okamoto, Kazuki, Tainaka
openaire   +2 more sources

Image1_Role of 5-methylcytosine in determining the prognosis, tumor microenvironment, and applicability of precision medicine in patients with hepatocellular carcinoma.PDF

, 2022
Background: 5-methylcytosine has a profound impact on the development and progression of hepatocellular carcinoma. The aim of this study was to investigate the usefulness of 5-methylcytosine in determining the prognosis, tumor microenvironment, and ...
Haiying Wang (6869), Min Zhao (66793), Jinzhen Cai (849136), Rongjian Xu (11464164), Mingyuan Luan (13808218)   +4 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Image5_Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer.TIF

, 2021
Background: DNA methylation is an important epigenetic modification, among which 5-methylcytosine methylation (5mC) is generally associated with tumorigenesis.
Xiaoning Li (581082), Ming Jiang (11433), Taisheng Liu (11085717), Xiaoshan Hu (728098), Jian Wang (5901), Guihong Liu (9351563), Jinye Zhang (1467106), Liyi Guo (11678977), Peng Yu (48605), Zili Dai (11678980), Jian Zhang (1682)   +10 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source