Results 101 to 110 of about 20,996,854 (289)

Ligand‐Defined Interfacial Chemistry Enables Instant and Sequence‐General DNA Chemisorption on Gold Nanoparticles Toward Label‐Free SERS With Single‐Base Resolution

Advanced Science, EarlyView.
Ascorbic Acid‐Engineered Interface Enables Universal DNA Functionalization on Gold Nanoparticles: Attenuating electrostatic repulsion and leveraging synergistic hydrogen‐bonding interactions significantly lowers the kinetic barrier for DNA adsorption, enabling rapid and sequence‐general functionalization of non‐thiolated DNA‐requiring only a single ...
Guangping Li, Cheng Wang, Xinyue Wu, Zhongxiang Ding, Heng Gao, Zhonggang Liu, Yu Zhang, Jinai Chen, Feng Wang, Honglin Liu   +9 more
wiley   +1 more source

5-Methylcytosine content in Gryllotalpa fossor (Orthoptera)

, 1992
The MspI-HpaII digestion patterns of Gryllotalpa fossor (Scudder) DNA indicated the methylation of internal cytosine in the sequence 5′ -CCGG-3′. The amount of 5-methylcytosine (5mC) was estimated by HPLC analysis to be about 0.6–0.8%, which constitutes
Soma Sarkar, R. R. Hendre, S. R. V. Rao, V. S. Gupta   +3 more
core   +1 more source

DataSheet1_Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer.xlsx

, 2021
Background: DNA methylation is an important epigenetic modification, among which 5-methylcytosine methylation (5mC) is generally associated with tumorigenesis.
Xiaoning Li (581082), Ming Jiang (11433), Taisheng Liu (11085717), Xiaoshan Hu (728098), Jian Wang (5901), Guihong Liu (9351563), Jinye Zhang (1467106), Liyi Guo (11678977), Peng Yu (48605), Zili Dai (11678980), Jian Zhang (1682)   +10 more
core   +1 more source

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

Advanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena, Bhavana Ramadas, Sidney Becker   +2 more
wiley   +1 more source

TET-mediated 5-methylcytosine oxidation in tRNA promotes translation

Journal of Biological Chemistry, 2020
Oxidation of 5-methylcytosine (5mC) in DNA by the ten-eleven translocation (TET) family of enzymes is indispensable for gene regulation in mammals. More recently, evidence has emerged to support a biological function for TET-mediated m5C oxidation in ...
Huiqing Shen, R. Ontiveros, Michael C. Owens, M. Liu, Uday Ghanty, R. Kohli, K. Liu   +6 more
semanticscholar   +1 more source

5-hydroxymethylcytosine profiling as an indicator of cellular state [PDF]

, 2013
DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including carcinogenesis. There have been
Meehan, Richard, Harrison, David J, Thomson, John P, Meehan, Richard R., Thomson, John P., Laird, Alexander, Harrison, David J.   +6 more
core   +1 more source

Image2_Role of 5-methylcytosine in determining the prognosis, tumor microenvironment, and applicability of precision medicine in patients with hepatocellular carcinoma.PDF

, 2022
Background: 5-methylcytosine has a profound impact on the development and progression of hepatocellular carcinoma. The aim of this study was to investigate the usefulness of 5-methylcytosine in determining the prognosis, tumor microenvironment, and ...
Haiying Wang (6869), Min Zhao (66793), Jinzhen Cai (849136), Rongjian Xu (11464164), Mingyuan Luan (13808218)   +4 more
core   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark

Wiley Interdisciplinary Reviews - RNA, 2018
It is a well‐known fact that RNA is the target of a plethora of modifications which currently amount to over a hundred. The vast majority of these modifications was observed in the two most abundant classes of RNA, rRNA and tRNA.
Lukas Trixl, A. Lusser
semanticscholar   +1 more source

Image4_Role of 5-methylcytosine in determining the prognosis, tumor microenvironment, and applicability of precision medicine in patients with hepatocellular carcinoma.PDF

, 2022
Background: 5-methylcytosine has a profound impact on the development and progression of hepatocellular carcinoma. The aim of this study was to investigate the usefulness of 5-methylcytosine in determining the prognosis, tumor microenvironment, and ...
Haiying Wang (6869), Min Zhao (66793), Jinzhen Cai (849136), Rongjian Xu (11464164), Mingyuan Luan (13808218)   +4 more
core   +1 more source