Results 111 to 120 of about 20,996,854 (289)
Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Advanced NanoBiomed Research, EarlyView.Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
Protein Interactions at Oxidized 5-Methylcytosine Bases
Journal of Molecular Biology, 2020 5-Methylcytosine (5mC), the major modified DNA base in mammalian cells, can be oxidized enzymatically to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the Ten-Eleven-Translocation (TET) family of proteins.
Pfeifer, Gerd P +2 more
openaire +5 more sources
Nature Communications, 2019 The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m5C) however, it is largely unknown how it recruits or repels RNA-binding proteins.
Abdulrahim A. Sajini +9 more
semanticscholar +1 more source
Journal of Translational Medicine, 2020 Post-transcriptional methylation modifications, including 5-methylcytosine (m5C) modification, are closely related to the tumorigenesis of cancers. However, the mRNA profile of m5C modification in hepatocellular carcinoma (HCC) is unknown. Methylated RNA
Qiyao Zhang +4 more
semanticscholar +1 more source
, 2016 The substitution effect on hydrogen-bond energy of the Watson−Crick type base pair formation between 1-methylcytosine and chemically modified 9-methylguanine derivatives was evaluated by an ab initio molecular orbital theory.
Tadafumi Uchimaru (1889776) +3 more
core +1 more source
, 2022 Background: 5-methylcytosine has a profound impact on the development and progression of hepatocellular carcinoma. The aim of this study was to investigate the usefulness of 5-methylcytosine in determining the prognosis, tumor microenvironment, and ...
Haiying Wang (6869) +4 more
core +1 more source
A cost‐effective DNA extraction protocol for long‐read sequencing in non‐model plants
Applications in Plant Sciences, EarlyView.Abstract Premise Third‐generation sequencing has revolutionized genomics, enabling in‐depth analysis of genome sequence, structure, and epigenetic features. Yet, extracting high‐quality DNA for long‐read sequencing remains a bottleneck—particularly in non‐model plants, such as mature trees growing in natural environments, which often contain abundant ...
Sofia Gaischuk +6 more
wiley +1 more source
Evaluation of different computational methods on 5-methylcytosine sites identification
Briefings Bioinform., 2019 5-Methylcytosine (m5C) plays an extremely important role in the basic biochemical process. With the great increase of identified m5C sites in a wide variety of organisms, their epigenetic roles become largely unknown.
Hao Lv +5 more
semanticscholar +1 more source
Phosphopeptides Designed for 5-Methylcytosine Recognition
, 2016 An artificial phosphopeptide has been developed through rational design of the interaction with 5-methylcytosine in duplex DNA. The peptide consists of two tandem zinc finger motifs, in one of which the glutamate was replaced with a phosphotyrosine, the ...
Akiko Nomura (2205580) +1 more
core +1 more source
, 2022 In recent years, methylation modification regulators have been found to have essential roles in various tumor mechanisms. However, the relationships between N6-methyladenosine (m6A) and 5-methylcytosine (m5C) regulators and clear cell renal cell ...
Zeyu Li (4371955) +6 more
core +1 more source